Báo cáo khoa học: The bI/bIII-tubulin isoforms and their complexes with antimitotic agents pptx

... with Arg320. The models of the complexes of IDN5390 with the bI and bIII-tubulin isoforms are shown in Fig. 5. The bound conformation of the ligand is quite similar in the I1 and I3 complexes, ... with the ligand, notwith- standing the shift in the ligand position with respect to the E1 complex. Due to the described differences between the two binding...

Ngày tải lên: 16/03/2014, 13:20

... described by the main verb of the sentence; the perfecg event; and the progressivJe event. The representation of every sentence involves the ut- terance event and the main event; sentences with ... precede(End, now) The predicate holds in the first clause of the repre- sentation takes three arguments, representing the predicate and the beginning and...

Ngày tải lên: 21/02/2014, 20:20

... genes. On the other hand, the lack of growth of the wildtype strain on D -allitol and L -iditol may either be due to a lack of uptake of these hexitols, or due to alackoflad1 expression by these ... in polyol binding in the SDH [25] are also absolutely conserved in Lad1, and thus cannot determine the binding efficacy of hexitols and pentitols. On the other hand, many of the...

Ngày tải lên: 07/03/2014, 15:20

... would be the Replacement frame, with FEs such as OLD and NEW as in the sentence Pat re- placed [ Old the curtains] [ New with wooden blinds]. One sense of the verb replace is associated with the Replacement ... FEs are annotated with a triplet of labels, one for the FE name, one for the phrase type and one for the grammatical function of the constituent with re...

Ngày tải lên: 08/03/2014, 04:22

... in the RPE by immunohistochem- istry, consistent with the ADH4 activity previously found in this epithelium [25]. Thus, the presence in the RPE, the high activity with 11-cis-retinol, and the ... the substrate in the binding pocket of ADH4 is the reason for the low activity observed with this retinal isomer. The interaction of 11-cis-retinal with ADH1B1 was als...

Ngày tải lên: 23/03/2014, 12:20

... actual events standing in the part-of relation to hypothetical super-events. This treatment extends and refines those of Moens and Steedman (1988) and Jackendoff (1991), at least for the restricted ... of the material entities, and similarly 1These are elsewhere called 'directed-motion' events. 2This move is intended to resolve certain empirical and computation...

Ngày tải lên: 31/03/2014, 06:20

... proceed the utterance of the corresponding speech reference. Further, we computed the average absolute length of the time gap and the average number of fixated object changes, as well as their variances ... heavily overlapped, such as the candle (with object ID 26) and the chair (with object ID 25), and both were considered correct for the re- spective spoken words....

Ngày tải lên: 20/02/2014, 12:20

... appropriate for the intended reader. Our sys- tem analyzes web text and returns the thematic area and the expected reading difficulty of the re- trieved texts. 1 To our knowledge, Read-X is the first ... experiment with a sys- tem that employs grammatical features and vocab- ulary to predict readability. The system is part of the the REAP tutor, designed to help ESL learn-...

Ngày tải lên: 22/02/2014, 02:20

... [18,44–52]. The mice either expressed human wild-type a-synuclein or the human protein carrying one of the two main mutants (A53T or A30P). These mice differ in the level of expression of the protein and ... aggregation at the C- and N-terminal copper binding sites. These conflicting reports and the weak affinity constants mean that whe- ther Cu binds or not and where is u...

Ngày tải lên: 07/03/2014, 10:20

... writ- ten in the abbreviated form ( X/Y) in the tables. In accordance with the procedures described by the definitions and augmented by our conventions, the strong and weak affixes with respect ... mandatory decom- position point, and so Cls( L/LY) cannot be considered as a defining class for - LY either. Hence the effect of the convention is to delete from the...

Ngày tải lên: 07/03/2014, 18:20