Báo cáo khoa học: Aberrant interchain disulfide bridge of tissue-nonspecific alkaline phosphatase with an Arg433 fi Cys substitution associated with severe hypophosphatasia pdf

... Journal compilation ª 2006 FEBS Aberrant interchain disulfide bridge of tissue-nonspecific alkaline phosphatase with an Arg433 fi Cys substitution associated with severe hypophosphatasia Makiko Nasu 1 , ... tissue-non-specific alkaline phosphatase with an Arg 54 fi Cys substitution and a counterpart with an Asp 277 fi Ala substitution...

Ngày tải lên: 16/03/2014, 12:20

... model of the PDGF-C growth factor domain indicates the disulfide bridges in PDGF-C to consist of Cys2 50 and 294, Cys2 80 and 335, and Cys2 87 and 337, and the inter- monomeric bonds to consist of Cys2 74 ... carcinoma, with enlarged liver having multilocular pseudocysts without epithelial lining and showing increased angiogenesis. Both PDGF-A and -B are expressed in animal mod-...

Ngày tải lên: 19/02/2014, 07:20

... the CXXAH variant of P. denitrificans cytochrome c 550 is unstable and cannot be made, the two single-cysteine-containing (and AXXAH) variants of H. thermophilus cytochrome c 552 can form stably ... which contribute to the handling of heme and ligation of heme to the apocytochrome, and those involved in the provision of reductant to the apocytochrome in order to reduce a potential d...

Ngày tải lên: 06/03/2014, 09:22

... variation of pH in the range between 6.3 and 7.7, of ionic strength between 25 and 100 mm NaCl and of temperature between 278 and 313 K did not lead to any detectable change in the populations of the ... Ter-Avanesyan MD & Peltz SW (1998) The surveillance complex inter- acts with the translation release factors to enhance termination and degrade aberrant mRNAs. Genes Dev 12, 1...

Ngày tải lên: 06/03/2014, 11:20

... sequence homology with protein disulfide isomerases from other species, and 70% homology with human protein disulfide isomerase. Enzymatic analyses of recombi- nant C. marmoreus protein disulfide isomerase ... similarities with human protein disulfide isomerase. Using conotoxins tx3a and sTx3.1 as substrate, we analyzed the oxidase and isomerase activities of the C. marmoreus pr...

Ngày tải lên: 07/03/2014, 05:20

... react with cysteines on PDI to form a disulfide bond. Using MALDI-TOF ⁄ TOF MS analy- sis, we were able to show that disulfide bond forma- tion occurs between an open thiol form of bacitracin and Cys3 14 ... coimmuno- Fig. 5. Disulfide bond formation between bacitracin and Cys3 45 on PDI. (A) Scheme of thiol formation of the thiazoline ring of bacitracin A with subsequent f...

Ngày tải lên: 14/03/2014, 23:20

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Ngày tải lên: 06/03/2014, 22:20

Ngày tải lên: 06/03/2014, 22:20

... O-acetylation phenotype of human colonic mucosa. J. Pathol. 174, 169– 174. 35. Jass, J.R., Allison, L.J. & Edgar, S.G. (1995) Distribution of sia- losyl Tn and Tn antigens within normal and malignant colorectal epithelium. ... can also undergo further modifications at any one of four hydroxyl groups, located at C-4, -7, -8 and -9. One such modification, the formation of O-acetyl est...

Ngày tải lên: 07/03/2014, 14:20