Báo cáo khoa học: Distinct but critical roles for integrin aIIbb3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin pot

... Authors Journal compilation ª 2006 FEBS 5043 Distinct but critical roles for integrin a IIb b 3 in platelet lamellipodia formation on fibrinogen, collagen-related peptide and thrombin Kelly Thornber 1 , ... necessary for platelet lamellipodia forma- tion on CRP, thrombin and fibrinogen, but that thrombin is able to mediate lamellipodia fo...

Ngày tải lên: 16/03/2014, 12:20

... horizontal bars cor- respond to the regions of the protein involved in interaction with Cdk2 and cyclin A: 1, domain 1 interacting with cyclin A; 2, a linker helix involved in binding both cyclin ... limitations, ana- lysis of existing protein–protein interaction data can lead to useful information. Comparison of protein–protein interaction networks across species has significant potenti...

Ngày tải lên: 07/03/2014, 21:20

... O 2 Menadione is a cytotoxic quinone acting through a cycling reaction, implying its one-electron reduction to a semiquinone radical and subsequent reaction with molecular oxygen with the formation ... & Lagunas, R. (1976) Determination of intermediary metabolites in yeast. Critical examination of the effect of sampling conditions and recommendations for obtaining true levels....

Ngày tải lên: 17/03/2014, 10:20

... scattering studies of a IIb b 3 solution conformation. Biochemistry 32, 3935–3941. 34 Rocco M, Spotorno B & Hantgan RR (1993) Modeling the a IIb b 3 integrin solution conformation. Protein Sci ... JW (2001) Binding of a fibrinogen mimetic stabilizes integrin aIIbb3 s open conformation. Protein Sci 10, 1614–1626. 36 Ye F, Liu J, Winkler H & Taylor KA (2008) Integrin a IIb b 3 in...

Ngày tải lên: 18/02/2014, 04:20

... the following contribu- tions: • we formulate the question retrieval task as a phrase-based translation problem by modeling the contextual information (in Section 3.1). • we linearly combine the ... captures contextual information in modeling the translation of phrases as a whole, rather than translating single words in isola- tion. Experiments conducted on real Q&A data demonstrat...

Ngày tải lên: 20/02/2014, 04:20

... Proceedings of the ACL Interactive Poster and Demonstration Sessions, pages 53–56, Ann Arbor, June 2005. c 2005 Association for Computational Linguistics SenseLearner: Word Sense Disambiguation for ... meaning to a polyse- mous word within a given context. Applications such as machine translation, knowledge acquisition, com- mon sense reasoning, and others, require knowledge about wo...

Ngày tải lên: 20/02/2014, 15:20

... on semantic types of the input clause, resulting in a top-down planner for selecting and ordering content. 6 Conclusions In this paper we presented a technique for extract- ing order constraints ... free- order information is kept in the don’t care model. The patterns, and ordering constraints among them, provide abackbone of relatively fixed struc- ture, while don’t cares are...

Ngày tải lên: 20/02/2014, 18:20

... classes. 5.2 Normalized Mutual Information Mutual Information (I) measures the information that C and L share and can be expressed by using entropy and conditional entropy: I = H(C) + H(L) − ... within a cluster overlap in information, but they do not have to be identical in meaning. In contrast to paraphrases sentences in a cluster do not have to cover the same amount of info...

Ngày tải lên: 08/03/2014, 01:20

... the intrinsic kinetic deuter- ium isotope effects for both 7-OMe and 7-OEt coumarin dealkylation reac- tions. The apparent intrinsic isotope effect for P450 1A2 (9.4 for O-demethylation, 6.1 for ... microsomes. Results and discussion Intramolecular kinetic isotope effects The intramolecular kinetic isotope effects measure the comparative rates for cleavage of a C-H bond and a...

Ngày tải lên: 16/03/2014, 13:20

... protein stability and protein func- tion. Proc. Natl Acad. Sci. USA 92, 452–456. 3. Tang, K.E. & Dill, K.A. (1998) Native protein fluctuations: the conformational-motion temperature and the inverse ... step in enzyme catalysis. This information may indicate a suitable amino-acid residue in the active site as a target for protein engineering that could result in activation of th...

Ngày tải lên: 23/03/2014, 15:21