Báo cáo khoa học: The retinoid-X receptor ortholog, ultraspiracle, binds with nanomolar affinity to an endogenous morphogenetic ligand pptx
Tài liệu Báo cáo khóa học: The unusual methanogenic seryl-tRNA synthetase recognizes tRNASer species from all three kingdoms of life pptx
... archaeal organisms [2,3] and to determine to what extent they follow the rules accounting foridentitiesinprokaryotesandeukaryotes[1,4,5].Inspite of the universality of the genetic code, there are ... that two other methanogenic SerRSs with atypical amino acid sequences, one from thermophile Methanococcus jannaschii and the other from mesophile M. maripaludis, recognize eukaryoti...
Ngày tải lên: 19/02/2014, 12:20
Tài liệu Báo cáo Y học: The Fc receptor c-chain is necessary and sufficient to initiate signalling through glycoprotein VI in transfected cells by the snake C-type lectin, convulxin ppt
... collagen receptor present in platelets and megakaryocytes. It belongs to the superfamily of immunoblobulin receptors and is closely related to Fca receptor (FcaR) and natural killer receptor [1]. The ... flow cytometry using the GPVI-specific ligand convulxin and antibody to convulxin (Fig. 1A). COS/F1 or mutant versions in which the transmembrane arginine of GPVI was muta...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo khoa học: The product chain length determination mechanism of type II geranylgeranyl diphosphate synthase requires subunit interaction pptx
... inhibitor substrate analogues were made with type 1 FPSs from human [11] and pro- tozoa [6,12], and some of the structures [e.g. FPS from human (2F94 and 3B7L) and Trypanosoma brucei (2P1C and 2I19) binding ... directly touches the x-end of GGPP bound in the same subunit, whereas phenylalanine 108 supplied from the other subunit exists in the proximity of the x-end [24]. These r...
Ngày tải lên: 07/03/2014, 06:20
Báo cáo khoa học: The viral SV40 T antigen cooperates with dj2 to enhance hsc70 chaperone function docx
... the presence of dj2, hsc70 bound mutTAg in an ATP-independent fashion (Fig. 1B, lanes 5 and 6). These findings led us to hypothesize that dj2 binds T antigen in an ATP independent manner and the resulting ... dj2. The reduced amounts of hsc70 bound to TAg prior to dj2 addition (lanes 1 and 5) are probably due to the fact that the binding affinity of dj2 to hsc70 is s...
Ngày tải lên: 16/03/2014, 05:20
Tài liệu Báo cáo khoa học: Secondary substrate binding strongly affects activity and binding affinity of Bacillus subtilis and Aspergillus niger GH11 xylanases docx
... significant importance for XBS and XAN. The SBS in these single domain xylanases may be an example of a very efficient strategy that targets the enzyme towards a substrate to anchor and feed it into the ... compared to a partially closed right hand [21]. The SBS are present in different regions of the GH11 xylanases. In the B. circulans xylanase and in XBS, the SBS is locate...
Ngày tải lên: 14/02/2014, 19:20
Tài liệu Báo cáo khoa học: The pro-form of BMP-2 interferes with BMP-2 signalling by competing with BMP-2 for IA receptor binding pptx
... constants for interaction of the ECD of BMPR-IA with the growth factors. Association (k a ) and dissociation (k d ) rates for the ligands with the ECD and the apparent dissociation con- stants ... type I receptor molecules are bound by the dimeric ligand. Subsequently, two type II receptor molecules are recruited by the ligand type I receptor complex. This associati...
Ngày tải lên: 18/02/2014, 06:20
Tài liệu Báo cáo khoa học: The endogenous retinoid metabolite S-4-oxo-9-cis-13,14-dihydro-retinoic acid activates retinoic acid receptor signalling both in vitro and in vivo pdf
... 2009) doi:10.1111/j.1742-4658.2009.07023.x Retinoic acid receptor (RAR) and retinoid X receptor are ligand- induced transcription factors that belong to the nuclear receptor family. The receptors are activated by small hydrophobic ... conformational changes of both RARa and RAR b As S-4o9cDH-RA induced retinoid receptor- dependent gene transcription, we wanted to investigate w...
Ngày tải lên: 18/02/2014, 08:20
Tài liệu Báo cáo khoa học: The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor pptx
... phosphorylation restored full maturation of the K650M receptor to a significant degree. To firmly establish that SU5402 allowed the K650M receptor to be transported to the plasma membrane and endocytosed, ... that the 130 and 115 kDa bands (or 144 and 129 kDa bands in the X807R mutant) corresponded to differ- ently glycosylated forms of the receptor, immunopre- cipita...
Ngày tải lên: 19/02/2014, 00:20
Tài liệu Báo cáo khoa học: The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression ppt
... may be essential to ensure the tight control of NTHi- induced TLR7 up-regulation and the resultant host antiviral response. We can further speculate that the CYLD-dependent autoregulatory feedback ... submerged for the first 7 days and then the air ⁄ liquid interface was created by removing medium from the apical compartment of the cultures. The culture medium was changed eve...
Ngày tải lên: 19/02/2014, 00:20
Báo cáo khoa học: Estrogen-related receptor a and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria potx
... indicating that other regulatory fac- tors are implicated in the coordination of the expres- sion of the nuclear and mitochondrial genomes. ERRa is an orphan nuclear receptor that binds to the ERR response ... XCT790. XCT790, an artificial synthetic compound, is known to interfere specifically with the ligand- binding domain of ERRa without affecting estrogen receptor...
Ngày tải lên: 06/03/2014, 09:22