... little is known about how the initial molecu-lar activity of Sry is translated into cellular structureand organ morphology. Interestingly, Dmrt1, the ancestor of Dmrt 1bY, is one of the downstream ... dmrt 1bY regulation mechanisms could be shown. Tran-scriptional regulation: the feedback autoregulation of dmrt 1bY promoter activity and transregulation by its paralogue Dmrt1a is akey mechanism ... zinc ion each, andbinds to the minor groove of the DNA [6]. Dmrts wereoriginally described to play important roles during sexdetermination in flies and worms by regulating severalaspects of...