Báo cáo khoa học: Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage Crystal structure and biochemical studies pot
Báo cáo khoa học: Importance of tyrosine residues of Bacillus stearothermophilus serine hydroxymethyltransferase in cofactor binding and L-allo-Thr cleavage Crystal structure and biochemical studies pot
... of tyrosine residues of Bacillus
stearothermophilus serine hydroxymethyltransferase
in cofactor binding and
L-allo-Thr cleavage
Crystal structure and biochemical studies
B. S. Bhavani
1,
*, V. ... The
superposition of Y61A bsSHMT–Gly and bsSHMT–
Gly–FTHF shows that the mutation of Y61 to A cre-
ates a large cavity near the binding site of the pt...
Báo cáo khoa học: A single EF-hand isolated from STIM1 forms dimer in the absence and presence of Ca2+ ppt
... distance between
the two termini of the inserted Ca
2+
-binding sites in
the model structure of the EF-hand of STIM1 is within
15 A
˚
. Accordingly, a total of six glycine linkers is suffi-
cient to ... dimerization and calcium binding
in an EF-hand synthetic peptide. J Theor Biol 199, 199–
211.
12 Julenius K, Robblee J, Thulin E, Finn BE, Fairman R
& Linse S (2002) Cou...
Báo cáo khoa học: The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases docx
... of residues: 26–121 and 325–343
(chain A), 266–295 (chain B) and 385–399 (chain C) in
SmPAL
out ⁄ in
and 33–128 and 333–351 (chain A), 272–303
(chain B) and 293–306 (chain C) in PlPAL
out ⁄ in
. ... taxol
biosynthesis in Taxus chinensis [27] or T. cuspidata
[28] and tyrosine 2,3-aminomutase (TAM), which is
involved in biosynthesis of a natural product having
pot...
Báo cáo khoa học: "Importance of linguistic constraints in statistical dependency parsing" ppt
... 2009). For example,
even in case of coordination, coordinating con-
junction is the head and conjuncts are children of
the coordinating conjunction. The coordinating
conjunction is attached ...
4.1 Hindi
Recently in NLP Tools Contest in ICON-2009
(Husain, 2009 and references herein), rule-based,
constraint based, statistical and hybrid approach-
es were explored for par...
Báo cáo khoa học: "Importance of Pronominal Anaphora resolution in Question Answering systems" pot
... SelectingAntecedent ( INPUT L: ListOfCandidates,
OUTPUT Solution: Antecedent )
Apply restrictions to L with a result of L1
Morphologic agreement
C-command constraints
Semantic consistency
Case of:
NumberOfElements ... the same number of parsed
constituents as the anaphora
6) Candidates that have appeared with the verb of
the anaphor more than once
7) Preference for indefinite NPs.
Ca...
Báo cáo khoa học: Key substrate recognition residues in the active site of a plant cytochrome P450, CYP73A1 ppt
... identified
N302 and I371 as key determinants of substrate binding
and orientation for catalysis. K484 is not involved in
initial substrate binding, but seems to play a significant
role in catalysis, ... results in
close to 50% loss in C4H activity, does not affect I2C
hydroxylation. As initial cinnamate binding is not in u-
enced by this mutation (Table 2) and binding ki...
Báo cáo khoa học: The catalytic significance of the proposed active site residues in Plasmodium falciparum histoaspartic protease ppt
... position of
Lys78 is anchored with an interaction between the
main chain oxygen of Ala216 and the e-amine of
Lys78. In H34A mutant (Fig. 6B), the interaction
between the imidazole ring and Asp214 ... reported secondary structures of
pepsin-like aspartic proteases which are predominately
b sheet [16].
On the basis of the kinetic behavior of the H34A
and S37A mutants and t...
Báo cáo khoa học: Importance of the gating segment in the substrate-recognition loop of pyranose 2-oxidase pptx
... roles in substrate binding and the specificity
and catalysis of enzymes [27–29], as well as in stabiliz-
ing tertiary and quaternary structure [30–32]. On the
basis of previous crystal- structure ... For
the ligand complexes, crystals were immersed for < 1 min
in a drop of stabilizing solution containing a grain of solid
ligand before being vitrified. All data sets...
Báo cáo khoa học: Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (AriceptÒ) to cholinesterases doc
... positioning of
inhibitors in alternate configurations [34]. The importance
of gorge dimensions in accommodating bulky inhibitors
was also seen in the binding of propidium, decamethonium,
tacrine and ... structure regarding the role of Phe330 in the
binding and selectivity of inhibitors to AChE, is not
unique to E2020 and was noted for huperzine A and
tacrine a...
Tài liệu Báo cáo khoa học: The tandemly repeated domains of a b-propeller phytase act synergistically to increase catalytic efficiency doc
... Asp188, Ala208 and Gly234). Some of the res-
idues involved in phosphate and calcium binding are
conserved in the PhyH-DII sequence, whereas only
one phosphate -binding residue is conserved in the
PhyH-DI ... presence of Ca
2+
increased the thermal stability of PhyH and PhyH-DII.
After incubation at 60 °C for 30 min, both enzymes
retained > 70% of their initial activ...