Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx

... (2008) 339 7–3 407 ª 2008 The Authors Journal compilation ª 2008 FEBS 3407 Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition Anil ... protein site; LGR, leucine-rich repeat-containing G-protein- coupled receptor; LH, luteinizing hormone; LHR, luteinizing hormone...

Ngày tải lên: 16/03/2014, 06:20

... nuclear receptors [ 4 3 3–3 8]. In the study reported here, we used ESI-MS to charac- terize the binding of CoRNRs to the LBDs of the HD heterodimer. In particular, the in uence of ligand binding to RAR ... binding domain in its dimeric noncovalently bound form. Craig et al. [25] analyzed by microESI-MS the binding of the human vitamin D receptor and the r...

Ngày tải lên: 23/03/2014, 13:20

... protein, the degree of activation and the in uence of other proteins. Phosphorylation signaling pathways are intri- cately interrelated; it was previously shown that either induction or inhibi- tion ... effects depending on the binding proteins. For instance, the apoptotic effects of Bax on mito- chondria are inhibited by heterodimerization with Bcl-xL, which maintains Bax i...

Ngày tải lên: 14/02/2014, 22:20

... [102]. In the olfactory epithelium of 3–6 -week-old mice, the expression profile of HSF1 remains constant. However, a significant increase in the DNA-binding activity of HSF1 can be detected during the ... chaperones through binding to the hydrophobic surfaces of unfolded proteins, thereby facilitating refolding of pep- tides and preventing protein aggregation [32]....

Ngày tải lên: 18/02/2014, 04:20

... hindered by the occlud- ing loop and occurs by a two-step mechanism in which the N-terminus of the inhibitor first binds to the enzyme, displacing the occluding loop, followed by the binding of ... nm, depicting a strong interaction between 2A2 mAb and cathepsin B. Determination of the 2A2 mAb binding site on cathepsin B The binding site of 2A2 mAb on cathepsin...

Ngày tải lên: 18/02/2014, 11:20

... between the dCTP(dUTP)-binding conformer and the dTTP-binding conformer of dCTP deaminase. We were not able to identify structural changes in the main chain of the subunit, or in the interaction of ... prevented binding of the C-terminal residues over the active site, or the absence of the C-terminal residues caused the movement of the lip (Fig. 1B). In...

Ngày tải lên: 18/02/2014, 16:20

... Thus, the observed reduction in hormone response of the system in the presence of TSA correlates with detectable changes in the local chromatin architecture of the MMTV promoter. The TSA-induced leaky ... obtained for naked DNA (data not shown). Hence, there is no protein binding detected by the DMS methylation assay in the MMTV promoter in the noninduced...

Ngày tải lên: 19/02/2014, 12:20

... prompt termination of the pr otein s ynthesis. These data a dd to the growing body of information supporting a preponderant role of p38 in the regulation of gene expression at the level of mRNA stability. ... activators of the p38 and PtdIns 3 -kinase pathways including thr ombin, dexamethasone, angiotensin II and prostaglandins stimulate the expression o...

Ngày tải lên: 19/02/2014, 16:20

... entire length of thin filaments and is capable of modulating the r ate of formation of the a ctin– myosin complex [74,75]. Interestingly, nebulin also interacts with the titin PEVK domain in a calcium/calmodulin ... competitive effect of PEVK domain-containing T800 on the electrostatic contacts at the a ctin–HMM interface. They also suggest that titin may participate in...

Ngày tải lên: 19/02/2014, 16:20

... spermidine and spermine) through conversion of l-arginine into l-ornithine [16]. The lat- ter is in turn used by ODC to produce putrescine, the precursor of spermidine and spermine. To further ... ana- lyze the regulation of the polyamine-synthetic pathway in virus infection, ODC expression in SeV-infected Jurkat cells was studied. Kinetic analysis of ODC mRNA b...

Ngày tải lên: 07/03/2014, 21:20