Báo cáo khoa học: Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the b-ketoacyl reductase reaction pot
Báo cáo khoa học: Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the b-ketoacyl reductase reaction pot
... inhibitor of human fatty acid synthase
FEBS Journal 275 (2008) 1556–1567 ª 2008 FEBS 1567
Discovery of GSK837149A, an inhibitor of human fatty
acid synthase targeting the b-ketoacyl reductase reaction
Marı
´a
Jesu
´
sVa
´
zquez
1
, ... reported [27]. Therefore, the use of these
substrates can be exploited to analyze the effect of
FAS inhibitor...
Báo cáo khoa học: Natriuretic peptide system: an overview of studies using genetically engineered animal models doc
... cloning of the first mammalian
GC (thus called GC-A) from rats and humans [17].
Expression of the cloned enzyme confirmed that GC-A
is an ANP receptor. Soon after the discovery of GC-A,
cloning of a ... CNP.
The binding affinities of ANP, BNP and CNP to the
human or rat C receptor have been reported [21]. Irre-
spective of the species examined, the rank order of...
Báo cáo khoa học: "Vocabulary Choice as an Indicator of Perspective" pdf
... there is no evidence for the
relevance of the frequency composition of the
text for perspective classification, for all levels of
venue- and topic-control, from the tightest (PBA
debates) to the ... therefore hypothesize that the choice of vo-
cabulary is not only a matter of topic but also
of perspective, while word recurrence has mainly
to do with the topical compos...
Báo cáo khoa học: Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase doc
... after the
other with the three other GDC subunits, P-, T- and
L-protein. As a result of the GDC reaction cycle,
which requires the coenzymes NAD
+
and tetrahydro-
folate, methylene-tetrahydrofolate ... extension of
four amino acid residues at the N-terminus of each
recombinant protein after removal of the His tag (Fig.
S4). The kinetic differences between the norma...
Tài liệu Báo cáo khoa học: A tyrosinase with an abnormally high tyrosine hydroxylase/dopa oxidase ratio Role of the seventh histidine and accessibility to the active site docx
... wounding and infection by the pathogen
[16]. Thus, the timing and location of melanization
seems to be essential for the prevalence of one of these
two opposing processes. In any case, many of the ... the same micro-organism remain unknown.
The synthesis of melanin in micro-organisms has
been related to pathogenesis and virulence [14]. Melani-
zation of the infectiou...
Tài liệu Báo cáo khoa học: "ModelTalker Voice Recorder – An Interface System for Recording a Corpus of Speech for Synthesis" ppt
... recorded, the user rece-
ives feedback on the overall quality of the utter-
ance. Specifically, the user receives feedback on
the pitch, the overall amplitude, and the pronuncia-
tion of the recording. ... smoother, more natural sounding
synthesis, but requires many hours of recording,
often by a trained professional. The recording
process is usually supervised, and...
Tài liệu Báo cáo khoa học: "Going Beyond AER: An Extensive Analysis of Word Alignments and Their Impact on MT" pdf
... experiments to an-
alyze how different alignments affect the size of
the generated phrase tables, the distribution of the
phrases that are used in decoding, and the cover-
age of the test set with the generated ... show the
alignment links, and rectangles show the possible phrases.
In Figure 1, the first box represents a manual
alignment and the other two represen...
Báo cáo khoa học: Global shape and pH stability of ovorubin, an oligomeric protein from the eggs of Pomacea canaliculata pot
... ovorubin
is an anisometric particle with a major axis of 130 A
˚
and a minor one
varying between 63 and 76 A
˚
. The particle shape was not significantly
affected by the absence of the cofactor astaxanthin. ... 2.0
and pH 12.0 (Fig. 6) show a red shift of its emission
maxima (from 330 to 338 nm) and an intensity
decrease at pH 2.0, indicative of the exposure of
some of...
Báo cáo khoa học: Discovery of a eugenol oxidase from Rhodococcus sp. strain RHA1 ppt
... by the Dutch Technology
Foundation STW, the applied science division of
NOW, and the Technology Program of the Ministry
of Economic Affairs.
References
1 de Jong E, van Berkel WJH, van der Zwan ... employ
cytochrome domains to relay the electrons towards
azurin as electron acceptor. Another difference
between VAO and the bacterial hydroxylases is the
mode of binding of...
Báo cáo khoa học: Glycosphingolipids in Plasmodium falciparum Presence of an active glucosylceramide synthase pot
... as a potent inhibitor of the
intraerythrocytic maturation leading to an arrest of the
parasites at ring stage. Rings formed in the presence of
the drug contain no tubular structures. On the contrary,
mature ... methylate the rest of the fatty acids
that could interfere, and analysed by TLC in solvent C
(Fig. 2B). Two spots, migrating in the region where long
chai...
Từ khóa: