Báo cáo khoa học: Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the b-ketoacyl reductase reaction pot

... inhibitor of human fatty acid synthase FEBS Journal 275 (2008) 1556–1567 ª 2008 FEBS 1567 Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the b-ketoacyl reductase reaction Marı ´a Jesu ´ sVa ´ zquez 1 , ... reported [27]. Therefore, the use of these substrates can be exploited to analyze the effect of FAS inhibitor...

Ngày tải lên: 16/03/2014, 06:20

... cloning of the first mammalian GC (thus called GC-A) from rats and humans [17]. Expression of the cloned enzyme confirmed that GC-A is an ANP receptor. Soon after the discovery of GC-A, cloning of a ... CNP. The binding affinities of ANP, BNP and CNP to the human or rat C receptor have been reported [21]. Irre- spective of the species examined, the rank order of...

Ngày tải lên: 14/03/2014, 23:20

... there is no evidence for the relevance of the frequency composition of the text for perspective classification, for all levels of venue- and topic-control, from the tightest (PBA debates) to the ... therefore hypothesize that the choice of vo- cabulary is not only a matter of topic but also of perspective, while word recurrence has mainly to do with the topical compos...

Ngày tải lên: 17/03/2014, 00:20

... after the other with the three other GDC subunits, P-, T- and L-protein. As a result of the GDC reaction cycle, which requires the coenzymes NAD + and tetrahydro- folate, methylene-tetrahydrofolate ... extension of four amino acid residues at the N-terminus of each recombinant protein after removal of the His tag (Fig. S4). The kinetic differences between the norma...

Ngày tải lên: 23/03/2014, 04:20

... wounding and infection by the pathogen [16]. Thus, the timing and location of melanization seems to be essential for the prevalence of one of these two opposing processes. In any case, many of the ... the same micro-organism remain unknown. The synthesis of melanin in micro-organisms has been related to pathogenesis and virulence [14]. Melani- zation of the infectiou...

Ngày tải lên: 19/02/2014, 07:20

... recorded, the user rece- ives feedback on the overall quality of the utter- ance. Specifically, the user receives feedback on the pitch, the overall amplitude, and the pronuncia- tion of the recording. ... smoother, more natural sounding synthesis, but requires many hours of recording, often by a trained professional. The recording process is usually supervised, and...

Ngày tải lên: 20/02/2014, 09:20

... experiments to an- alyze how different alignments affect the size of the generated phrase tables, the distribution of the phrases that are used in decoding, and the cover- age of the test set with the generated ... show the alignment links, and rectangles show the possible phrases. In Figure 1, the first box represents a manual alignment and the other two represen...

Ngày tải lên: 20/02/2014, 11:21

... ovorubin is an anisometric particle with a major axis of 130 A ˚ and a minor one varying between 63 and 76 A ˚ . The particle shape was not significantly affected by the absence of the cofactor astaxanthin. ... 2.0 and pH 12.0 (Fig. 6) show a red shift of its emission maxima (from 330 to 338 nm) and an intensity decrease at pH 2.0, indicative of the exposure of some of...

Ngày tải lên: 07/03/2014, 06:20

... by the Dutch Technology Foundation STW, the applied science division of NOW, and the Technology Program of the Ministry of Economic Affairs. References 1 de Jong E, van Berkel WJH, van der Zwan ... employ cytochrome domains to relay the electrons towards azurin as electron acceptor. Another difference between VAO and the bacterial hydroxylases is the mode of binding of...

Ngày tải lên: 07/03/2014, 09:20

... as a potent inhibitor of the intraerythrocytic maturation leading to an arrest of the parasites at ring stage. Rings formed in the presence of the drug contain no tubular structures. On the contrary, mature ... methylate the rest of the fatty acids that could interfere, and analysed by TLC in solvent C (Fig. 2B). Two spots, migrating in the region where long chai...

Ngày tải lên: 07/03/2014, 15:20