... Venkatesh1,21Department of Chemical Engineering and 2School of Biosciences and Bioengineering, Indian Institute of Technology Bombay,Powai, Mumbai, IndiaCellular regulation is a result of complex interactions ... complex interactions arisingfrom DNA–protein and protein–protein binding, autoreg-ulation, and c ompartmentalization and shuttling o f regula-tory proteins. Experiments in molecular biology haveidentified ... [1 2–1 6]. The regulatory switchrecruits various elementary mechanisms, such as protein–DNA and protein–protein interactions, stoichiometry (number of binding sites and dimerization), shuttling,cooperativity...