Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx
Báo cáo khoa học: Regulation of DNp63a by tumor necrosis factor-a in epithelial homeostasis docx
... DNp63a by TNF-a was attenuated by inhibition of NF-jB, sug-gesting that activation of NF-jB may be involved in the regulation of the degradation of DNp63a. Interest-ingly, knockdown of DNp63a ... Ij-Ba, inhibitor of kappa B; JNK, c-jun N-terminal kinase;NF-jB, nuclear factor-jB; si, small interfering; TA, transactivating; TNF-a, tumor necrosis factor-a; 7AAD, 7-amino-actinomycin D.FEBS ... 673–682. Regulation of DNp63a by TNF-a H o. Lee et al.6522 FEBS Journal 274 (2007) 6511–6522 ª 2007 The Authors Journal compilation ª 2007 FEBS Regulation of DNp63a by tumor necrosis factor-a in epithelial...
- 12
- 452
- 0
Báo cáo khoa học: Regulation of secretases by all-trans-retinoic acid pot
... activation of protein kinase C(PKC) [9]. Links between retinoids and PKC were con-vincingly demonstrated [10], and even pointed to directbinding between PKCs and RA receptors and control of transcriptional ... 2009)doi:10.1111/j.1742-4658.2009.06992.xOne of the emerging approaches for the treatment of Alzheimer’s diseaseaims at reducing toxic levels of Ab-species through the modulation of secretases, namely by inducing a-secretase or inhibiting ... inhibiting b-secretase and⁄ orc-secretase activities, or a combination of both. Although there is increas-ing evidence for the involvement of retinoids in Alzheimer’s disease, theirsignificance in...
- 11
- 364
- 0
Báo cáo khoa học: Activation of PMCA by calmodulin or ethanol in plasma membrane vesicles from rat brain involves dissociation of the acetylated tubulin/PMCA complex pdf
... aliquots were incubated in the presence of increasing concentrations of calmodu-lin, followed by the immediate determination of PMCA activity and the amount of acetylated tubulinremaining in the membrane ... acetylated tubulin. Tubulin-free PMVs werethen incubated with purified brain tubulin containingtwo different proportions (differing by a factor of four) of the acetylated isoform. As shown in Fig. 6B,PMCA ... determined the amount of hydrophobic acety-lated tubulin by measuring the tubulin ⁄ PMCA com-plex. Using partitioning in Triton X-114 and westernblotting we also determined PMCA activity by mea-suring...
- 13
- 339
- 0
Tài liệu Báo cáo khoa học: Regulation of cathepsin B activity by 2A2 monoclonal antibody docx
... inhibitors, binding revers-ibly into the active site of the enzyme. Cystatins,including human cystatin C, are general inhibitors of cysteine proteases. For cathepsin B, their Kivalue is in nanomolar ... nm,depicting a strong interaction between 2A2 mAb andcathepsin B.Determination of the 2A2 mAb binding site oncathepsin BThe binding site of 2A2 mAb on cathepsin B wasdetermined by SPOT analysis ... displacing the occluding loop, followed by thebinding of another two loops of the inhibitor [24].Besides protein inhibitors, the irreversible epoxysucci-nyl inhibitor E-64 and other cathepsin...
- 13
- 417
- 0
Tài liệu Báo cáo khoa học: Regulation of dCTP deaminase from Escherichia coli by nonallosteric dTTP binding to an inactive form of the enzyme ppt
... dCTP(dUTP)-bindingconformer and the dTTP-binding conformer of dCTPdeaminase. We were not able to identify structuralchanges in the main chain of the subunit, or in theinteraction of subunits within ... of dCTP binding by dTTP. However, thepresence of dTTP in the assay incubation alsoincreased the apparent cooperativity of dCTP bind-ing, which indicates that the mechanism of dTTPinhibition ... alsoinvestigated by equilibrium binding. This revealed ahyperbolic binding curve (Fig. 4D) with a stochiometry of 1 : 1 of dTTP bound per subunit of dCTPdeaminase.Mutational analysis of amino...
- 11
- 577
- 0
Tài liệu Báo cáo khoa học: Regulation of the actin–myosin interaction by titin doc
... modification of the actin–HMMinterface, which results in the inhibition of HMM cross-linking to the N-terminal part of a ctin. This change of theactin–HMM ionic interface would be in contrast ... and T m–Tnbinding to actin induces a shortening of filament length andan increase in myosin sliding velocity, suggesting a strongsynergy between these two actin binding components in their functional ... entire length of thin filaments and iscapable of modulating the r ate of formation of the a ctin–myosin complex [74,75]. Interestingly, nebulin also interactswith the titin PEVK domain in a calcium/calmodulin...
- 10
- 515
- 0
Báo cáo khoa học: Regulation of arginase II by interferon regulatory factor 3 and the involvement of polyamines in the antiviral response potx
... was inhibited by MG-132[20], suggesting indirectly an involvement of NF-jBinArgII regulation. Our study is thus the first directdemonstration of the involvement of IRF-3 in ArgII regulation in ... iodide(PI) staining of apoptotic cells was quantified in VSV-infected Jurkat T cells in the absence or presence of spermine. As shown in Fig. 7, the presence of spermineduring VSV infection strongly ... (putrescine, spermidine and spermine) throughconversion of l-arginine into l-ornithine [16]. The lat-ter is in turn used by ODC to produce putrescine, theprecursor of spermidine and spermine. To further...
- 12
- 498
- 0
Báo cáo khoa học: Regulation of calpain B from Drosophila melanogaster by phosphorylation pot
... understanding of the regulation of calpain B. According to homolo-gous modeling, the amino acid residues phosphory-lated by PKA and the ERK isoforms are situated in sensitive regions of the molecule ... Myosin phosphatase interacts withand dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in theattenuation of daunorubicin-induced cell death by calyculin-A. ... calpain-mediated physiological processes [5], whereas phos-phorylation of Ser369 ⁄ Thr370 by protein kinase A(PKA) inhibits calpain action [6]. Nicotine-inducedphosphorylation by an isoform of...
- 14
- 314
- 0
Báo cáo khoa học: Regulation of luteinizing hormone receptor mRNA expression by mevalonate kinase – role of the catalytic center in mRNA recognition potx
... the site of ATP binding and may exploitcommon side chain interactions; or (b) the conforma-tions of residues involved in RNA binding may bedirectly or indirectly coupled to the binding of ATPand ... (2001)Investigation of invariant serine ⁄ threonine residues in mevalonate kinase. Tests of the functional significance of a proposed substrate binding motif and a site impli-cated in human inherited ... identifi-cation of a novel RNA binding protein that mediatesthe post-transcriptional regulation of LHR mRNA in the ovary [10–12]. This protein, initially named LHRmRNA binding protein (LRBP), was...
- 11
- 367
- 0
Báo cáo khoa học: Regulation of translational efficiency by different splice variants of the Disc large 1 oncosuppressor 5¢-UTR potx
... certain condi-tions, by the Jun N-terminal kinase, the P38c MAPkinase, the cyclin-dependent kinases 1 and 2 and thePDZ-binding kinase, resulting in changes in distribu-tion and stability of ... short).Since DLG1 is known to be altered in cancers of epithelial origin and is the target of oncogenic HPV,we were first interested in investigating the initiation of DLG1 transcription in epithelial ... some regulatory proteins or by inhibiting the bind-ing or scanning of the translational machinery [27].Then, we were interested in whether RNA secondarystructure within these UTRs could contribute...
- 13
- 332
- 0
Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpbáo cáo khoa học thủy sảnBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018chuyên đề điện xoay chiều theo dạngGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANTrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Nghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Chuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtMÔN TRUYỀN THÔNG MARKETING TÍCH HỢPQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ