Báo cáo khoa học: Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging pptx
Tài liệu Báo cáo khoa học: Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity pptx
... [12,14,15] and certain amino acids [16].A linkage between fatty acid synthesis in the CNSand feeding behavior was uncovered with the findingthat systemic or intracerebroventricular administrationof ... isocitrate dehydrogenase to increase citrate concentrationsand (b) inhibit AMPK thus derepressing ACC. The increase in mal-ony-CoA is thought to allosterically inhibit CPT1c to mediatechanges in ... peptide in hypo-thalamic malonyl-CoA while promoting an increase in proopiomelanocortin and cocaine and amphetamineregulated transcript. Taken together, these findingsprovide a compelling argument...
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Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt
... obese mice In order to gain insights into the potential biologicallyrelevant role of miR-27 in the regulation of adipose tis-sue functions in vivo, we examined the expression ofmiR-27 in the genetically ... with the literature [15], genes of the miR-17 ⁄ 92 cluster,including miR-17-5p, miR-20, and miR-92, were upreg-ulated during differentiation (Fig. 1A, right panel). Wefurther investigated the ... prevents the induction of PPARc andC⁄EBPa In order to delineate the mechanisms by which miR-27inhibits adipogenic differentiation, we investigated the effect of miR-27 on the expression of the...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... only within helix III,but also over a large portion of the protein, from Phe8to Met56, including the loop and the tight turn. At the same time, in the vicinity of the Arg53 hinge point,precisely ... of the experimental points accumulate rather close to the upper intercept of the theoretical curve and the fitting(solid) line, where the motion of a unique15N–1H vec-tor is defined by a single ... suggesting the occurrence of eithera kinking or tightening of the local geometry. Asimilar discontinuity had been noted in solution also in the Antp HD [8,9] and the Antp (C39S) HD [10],and indeed,...
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Tài liệu Báo cáo khoa học: A genetic screen identifies mutations in the yeastWAR1 gene, linking transcription factor phosphorylation to weak-acid stress adaptation docx
... DNA-binding zinccluster at the N-terminus, whereas the acidic activationdomain is usually present at the C-terminus. The mid-dle homology region (MHR) bridging the DNA-bind-ing and the activation ... were raised in rabbitsagainst a GST-War1p fusion protein containing 294 aminoacids of the C-terminal part of War1p (amino acids 650–944) fused in- frame to the C-terminus of GST. The genefusion ... wasabsent in the strain expressing War1p-R764D (Fig. 4A). In contrast, strains expressing the mutants War1p-K762N and War1p-F763M showed greatly increasedPdr12p concentrations in both the absence...
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Tài liệu Báo cáo khoa học: Unusual metal specificity and structure of the group I ribozyme fromChlamydomonas reinhardtii23S rRNA pptx
... explanation for GMP-inducedfolding of the ribozyme in Mn2+is that binding of the cosubstrate to its site induces a conformationalchange in the RNA that inhibits Mn2+binding atanother inhibitory ... guanosinecosubstrate (GMP). The concentration dependence of guanosine cosub-strate-induced folding suggests that it functions by interacting with the Gbinding site, perhaps by displacing an inhibitory Mn2+. ... Cr.LSU intron (line), which lacks the large P6extension and the last three nucleotides (AU XG) of the intron. The sizes of the intron (InDGb) and 5¢ exon (5E) are indicated. The arrowindicates...
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Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... binding and stoichiometries weredetermined from the binding isotherm by fitting a 1 : 1binding model to the data using the software provided by the manufacturer.ResultsReaction of fosfomycin ... lysine reduces the probability offorming the fully closed form of the protein. The results obtained with the K22V/R120K doublemutant protein point toward a central role of arginine 120 in the ... doi:10.1111/j.1432-1033.2004.04196.x the positively charged side chain of K22 participates in fosfomycin binding, thus providing a rationale for the loss offosfomycin binding to the K22V and K22E mutant proteins.However,...
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Tài liệu Báo cáo khoa học: A possible role of mitochondria in the apoptotic-like programmed nuclear death of Tetrahymena thermophila Takashi Kobayashi and Hiroshi Endoh docx
... stained the degenerating parental macronucleus, but not the othernuclei (Fig. 3C–E). Moreover, the density of stainingwas high around the degenerating macronucleus, pre-sumably corresponding to the ... which appear to be involved in the finalresorption of the parental macronucleus during PND in T. thermophila, and suggested the involvement ofmitochondria in this process [19]. In mammalian apop-tosis, ... would beinsufficient for ladder formation in the present study.However, our findings imply that the nuclease activityis involved in the process of DNA laddering (as is the case with EndoG) rather...
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Tài liệu Báo cáo khoa học: "A HYBRID APPROACH TO REPRESENTATION IN THE JANUS NATURAL LANGUAGE PROCESSOR" pot
... deriving as many entities as possible using operators in the intensionai logic. In this section we illustrate this point by showing how definitely referenced sets, information about kinds, in- ... representation /an- guages in order to focus on formally specifying domains and using ~hat specification in language processing rather than on defining new domain- independent representation ... node in the network. Our use of the operator THE, and the operator POWER for definite plurals follows Scha [25]. The operators KIND and SAMPLE follow Cad.son's analysis [10] of the semantics...
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Tài liệu Báo cáo khoa học: "Subgrammars, Rule Classes and Control in the Rosetta Translation System" ppt
... meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions are not elaborated ... cases the grammar writer has a certain ordering of the rules in mind, e.g. he may want to express that the rules for inserting determiners during NP-formation should be applied after the rules ... have the same semantic derivation tree. So this principle says that the information that has to be conveyed during translation is not only the meaning, but also the way in which the mean- ing...
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Báo cáo khoa học: Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus ppt
... of HSP70–YFP in Huntingtin-150Q–CFP inclusions revealed that HSP70 is mobilewithin the inclusion [20]. As the movement of HSP70 issignificantly slower in the inclusion than in the cytosol,HSP70 ... of the polyQ tract in at least nine proteinscauses neurodegenerative disorders [4,5,31,32]. PolyQexpansion in the Huntingtin protein causes Hunting-ton’s disease, and polyQ-expanded ataxin-1 ... proteins in vivo is essential for the fullunderstanding of these mechanisms, and spectroscopicanalyses in living cells will greatly aid the detailedanalysis of the processes involved in these...
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Từ khóa: báo cáo khoa học mẫubáo cáo khoa học y họcbáo cáo khoa học sinh họcbáo cáo khoa học nông nghiệpbáo cáo khoa học lâm nghiệpBáo cáo thực tập tại nhà thuốc tại Thành phố Hồ Chí Minh năm 2018Nghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDETrả hồ sơ điều tra bổ sung đối với các tội xâm phạm sở hữu có tính chất chiếm đoạt theo pháp luật Tố tụng hình sự Việt Nam từ thực tiễn thành phố Hồ Chí Minh (Luận văn thạc sĩ)Phát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngĐịnh tội danh từ thực tiễn huyện Cần Giuộc, tỉnh Long An (Luận văn thạc sĩ)Thơ nôm tứ tuyệt trào phúng hồ xuân hươngThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀMMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP