Báo cáo khoa học: Glycation damage targets glutamate dehydrogenase in the rat liver mitochondrial matrix during aging pptx

... [12,14,15] and certain amino acids [16]. A linkage between fatty acid synthesis in the CNS and feeding behavior was uncovered with the finding that systemic or intracerebroventricular administration of ... isocitrate dehydrogenase to increase citrate concentrations and (b) inhibit AMPK thus derepressing ACC. The increase in mal- ony-CoA is thought to allosterically inhibit CPT1c to...

Ngày tải lên: 14/02/2014, 22:20

... obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in the genetically ... with the literature [15], genes of the miR-17 ⁄ 92 cluster, including miR-17-5p, miR-20, and miR-92, were upreg- ulated during differentiation (Fig. 1A, right pane...

Ngày tải lên: 18/02/2014, 08:20

... only within helix III, but also over a large portion of the protein, from Phe8 to Met56, including the loop and the tight turn. At the same time, in the vicinity of the Arg53 hinge point, precisely ... of the experimental points accumulate rather close to the upper intercept of the theoretical curve and the fitting (solid) line, where the motion of a unique 15 N– 1 H ve...

Ngày tải lên: 18/02/2014, 16:20

... DNA-binding zinc cluster at the N-terminus, whereas the acidic activation domain is usually present at the C-terminus. The mid- dle homology region (MHR) bridging the DNA-bind- ing and the activation ... were raised in rabbits against a GST-War1p fusion protein containing 294 amino acids of the C-terminal part of War1p (amino acids 650– 944) fused in- frame to the C-terminu...

Ngày tải lên: 19/02/2014, 00:20

... explanation for GMP-induced folding of the ribozyme in Mn 2+ is that binding of the cosubstrate to its site induces a conformational change in the RNA that inhibits Mn 2+ binding at another inhibitory ... guanosine cosubstrate (GMP). The concentration dependence of guanosine cosub- strate-induced folding suggests that it functions by interacting with the G binding site, perhaps...

Ngày tải lên: 19/02/2014, 07:20

... binding and stoichiometries were determined from the binding isotherm by fitting a 1 : 1 binding model to the data using the software provided by the manufacturer. Results Reaction of fosfomycin ... lysine reduces the probability of forming the fully closed form of the protein. The results obtained with the K22V/R120K double mutant protein point toward a central role of argin...

Ngày tải lên: 19/02/2014, 13:20

... stained the degenerating parental macronucleus, but not the other nuclei (Fig. 3C–E). Moreover, the density of staining was high around the degenerating macronucleus, pre- sumably corresponding to the ... which appear to be involved in the final resorption of the parental macronucleus during PND in T. thermophila, and suggested the involvement of mitochondria in this pr...

Ngày tải lên: 20/02/2014, 03:20

... deriving as many entities as possible using operators in the intensionai logic. In this section we illustrate this point by showing how definitely referenced sets, information about kinds, in- ... representation /an- guages in order to focus on formally specifying domains and using ~hat specification in language processing rather than on defining new domain- independent repr...

Ngày tải lên: 21/02/2014, 20:20

... meaning of the rules (rule meanings). In Montague Grammar these meanings are ex- pressed in intensional logic. In the Rosetta system the meanings of rules and basic expressions are not elaborated ... cases the grammar writer has a certain ordering of the rules in mind, e.g. he may want to express that the rules for inserting determiners during NP-formation should be...

Ngày tải lên: 22/02/2014, 10:20

... of HSP70–YFP in Huntingtin- 150Q–CFP inclusions revealed that HSP70 is mobile within the inclusion [20]. As the movement of HSP70 is significantly slower in the inclusion than in the cytosol, HSP70 ... of the polyQ tract in at least nine proteins causes neurodegenerative disorders [4,5,31,32]. PolyQ expansion in the Huntingtin protein causes Hunting- ton’s disease, and po...

Ngày tải lên: 06/03/2014, 09:22