Báo cáo khoa học: Gonadotropin-releasing hormone: regulation of the GnRH gene pot

... Because of the recent discovery of GnRH- II as a new isoform of GnRH, the majority of the studies have been done on the GnRH- I promoter, and there are only a few regarding regulation of the GnRH- II gene. The ... reg- ulation of the GnRH- I and GnRH- II genes; for instance, there are different effects of the steroid hor- mones E 2 and P 4 on the two...

Ngày tải lên: 16/03/2014, 04:20

... activation of the EGFR, where the C-terminal lobe of the kinase domain of one of the monomers forming the dimeric receptor interacts with the N-terminal lobe of the apposed monomer [19,47,84]. Of relevance ... control of ligand binding [86]. This is a result of the interaction of the distal segment of the JM, par- ticularly the E663–S671 residues, wit...

Ngày tải lên: 06/03/2014, 09:22

... [25,26]. The first short sequence is similar to the consensus GGGGCUG of the intron splicing enhancer found down- stream of the microexon of the chicken cardiac troponin T gene. In this gene, the enhancer ... site at the beginning of the exon 3. We obtained the 3¢ lacking part of this mRNA by 3¢ RACE-PCR. As shown in Fig. 3, the 3¢ end of this transcript (K3g)...

Ngày tải lên: 23/03/2014, 20:22

... for the role of speech style; [4] for defense of competence). In addition to the system having a model of the user, the user will have a model of the system, determined by the nature of his ... inter- action should arise out of a coherent view of what the role is. The linguistic competence of the system is an important element of the image it convey...

Ngày tải lên: 24/03/2014, 01:21

... stimulates the production of these miR- NAs and thus represses the expression of their target genes. TGF-b signaling is known to be involved in the epithelial–mesenchymal transition (EMT). The transcription ... post-translational modification of gene products. The discovery of microRNAs (miRNAs), which regulate gene expression post-transcriptionally, has added to the co...

Ngày tải lên: 14/02/2014, 19:20

... [23–26]. The consumption of NAD + and the generation of OAADPr by class III HDACs probably serve as a link between deacetylation and other physiological processes. Although the roles of OAADPr ... rear- rangement in the presence of OAADPr. The authors hypothesize that OAADPr, the product of Sir2 histone deacetylation, directly binds to one or more constitu- ents in the...

Ngày tải lên: 20/02/2014, 01:20

... transactivation [62] may relate to the altering of the redox balance of the cell, which then may affect the catalytic activity of PHD/HPHs and FIH-1. Finally, it is possible that these other reported agents that ... different domains of the HIFa subunits, affecting distinct steps in the induction of the HIF complex. The numerous enzymes and their various targets may h...

Ngày tải lên: 20/02/2014, 23:20

... modulates the physiological status of the host cell to suit the needs of the virus. As the Rev protein accumulates, nuclear export of the singly and unspliced mRNAs is facilitated [11,12]. These ... for the expression of the other viral genes, for the synthesis of full-length genomic RNA and, ultimately, for the production of progeny virions (reviewed in [40])....

Ngày tải lên: 06/03/2014, 09:22

... is the first sugar phosphatase belonging to the family of NagD- like phosphatases to be characterized at the level of gene regulation. Results and Discussion The araL gene in the context of the ... DaraL. Above is displayed the coding sequence of the 5¢-end of the araL gene. The putative ribosome-binding site, rbs, is underlined. The 5¢-end of the ara...

Ngày tải lên: 14/03/2014, 23:20

... identified in the first intron of the ABCA1 gene and was reported to be involved in the reg- ulation of ABCA1 expression in the liver [21]. Recently, MiR-33, an intronic microRNA located within the gene encoding ... binds the C-terminal region of ABCA1 to mediate its post-translational regulation. (A) In the absence of cholesterol accumulation, LXRb ⁄ RXR heterodimer...

Ngày tải lên: 22/03/2014, 15:21