Báo cáo khoa học: Passage through the Golgi is necessary for Shiga toxin B subunit to reach the endoplasmic reticulum pptx
Báo cáo khoa học: Passage through the Golgi is necessary for Shiga toxin B subunit to reach the endoplasmic reticulum pptx
... is < /b> subvertedby StxB when the < /b> Golgi < /b> pathway is < /b> unavailable.Clearly StxB cannot be present in the < /b> cytosol whilemembrane bound. This suggested that the < /b> toxin < /b> wasable to dissociate from Gb3 while ... that Golgi < /b> passage < /b> is < /b> required for < /b> the < /b> toxins to enter the < /b> ER. In fact, an alternate pathway bypassing the < /b> Golgi < /b> is < /b> utilized bySV40 virus. Here we find that blocking Shiga < /b> toxin < /b> B access to the < /b> ... than at the < /b> plasma membrane, providing the< /b> possibility for < /b> some StxB to no longer be bound to the< /b> receptor [53]. Further examination of this effect is< /b> beyond the < /b> scope of this study. The < /b> ability...
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Báo cáo khoa học: ATPase activity of RecD is essential for growth of the Antarctic Pseudomonas syringae Lz4W at low temperature potx
... RecBC, RecBCDK177QandRecBK29QCD enzymes, and that the < /b> RecB motor is< /b> absolutely required for < /b> v recognition and RecA load-ing, while the < /b> RecD subunit is < /b> dispensable for < /b> motoractivity of the < /b> ... with the < /b> regulatory v sequence and RecArecombinase in the < /b> cell [4,38,39]. Although all the< /b> subunits of RecBCD contribute towards the < /b> activitiesof the < /b> complex, the < /b> RecD subunit in E. coli is < /b> required for < /b> ... coli BL21(DE3) produced RecD in inclusion bodies, asexperienced by others for < /b> E. coli RecD [2,3]. To obtain the< /b> native soluble form, we cloned the < /b> 6x His-RecD readingframe from pT21D-His into the...
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Báo cáo khoa học: "TENSE GENERATION IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING: SOME ISSUES IN THE DESIGN OF THE VERB EXPERT" pot
... identify the < /b> errors, if any, present in the < /b> former and to formulate some hypotheses about their causes. On the < /b> basis of these hy- potheses, the < /b> Tutor selects the < /b> next exercise which will test the < /b> ... has been thoroughly analyzed, the < /b> Tutor will possibly switch to other topics. 4. THE < /b> DOMAIN EXPERT The < /b> Domain Expert is < /b> devoted to generate the < /b> fight answers for < /b> the < /b> exercises proposed to the < /b> ... expertise; (b) is < /b> capable of modeling the < /b> student knowledge in order to discover the < /b> reason(s) of his mistakes, and (c) is < /b> able to make teaching more effective by applying different tutorial...
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Tài liệu Báo cáo khoa học: Evolutionary divergence of valosin-containing protein ⁄cell division cycle protein 48 binding interactions among endoplasmic reticulum-associated degradation proteins ppt
... all beenmapped to the < /b> N-domain of VCP (amino acids 1–199)[13,25,32,33]. As the < /b> VBM of Ube 4b is < /b> very similar to those of the < /b> above proteins, we hypothesized thatUbe 4b should also bind to the < /b> ... necessary < /b> for < /b> VCP binding inUbe 4b, Atx-3 and Hrd1, but the < /b> influence of neigh-bouring amino acids is < /b> indicated both by the < /b> require-ment for < /b> an additional leucine in Ube 4b and Hrd1 andby the < /b> lack ... mediatingbinding both on the < /b> Ube 4b Ufd2p side [8] and on the< /b> VCP–Cdc48p side.We then investigated whether the < /b> binding of each ofthese VBM-containing proteins to the < /b> N-domain ofVCP is < /b> disrupted in disease....
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Báo cáo khoa học: Polypyrimidine tract-binding protein is essential for early mouse development and embryonic stem cell proliferation potx
... recombinase Cre recombinase Probe A Probe B +/+ +/– –/– –/flox-hyg +/+ +/– 26.0 kb11.4 kb9.1 kb9.4 kb 7.1 kb 2.7 kb –/flox-hyg Sm A BH Bg A Bg E Ss BH A Sm BH BH Ss Sm BH A Ss ... known to betargets for < /b> mitotic inhibition [30,31]. The < /b> regulatorymechanism of the < /b> ES cell cycle is < /b> still unclear. We arecurrently investigating whether PTB is < /b> one of the< /b> important regulators for < /b> ... 6659gain further insight into the < /b> function of PTB in EScells, we first tried to establish Ptb) ⁄ )ES cells fromPtb) ⁄ )blastocysts; however, we could not obtain the< /b> Ptb) ⁄ )ES cells (Table 2),...
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Báo cáo khoa học: "Feature-Rich Part-of-speech Tagging for Morphologically Complex Languages: Application to Bulgarian" docx
... then{remove OldEnd; concatenate NewEnd}where Tag is < /b> the < /b> tag of the < /b> wordform, OldEnd is < /b> the < /b> string that has to be removed from the < /b> end of the < /b> wordform, and NewEnd is < /b> the < /b> string that has to be ... information as part of the < /b> tags. For < /b> example, there are six tags for < /b> verbs in the< /b> Penn Treebank: VB (verb, base form; e.g., sing),VBD (verb, past tense; e.g., sang), VBG (verb,gerund or present ... concatenated to the < /b> beginning of the < /b> word-form in order to produce the < /b> lemma.Here is < /b> an example of such a rule:if tag = Vpitf-o1s then{remove ; concatenate } The < /b> application of the < /b> above rule to the...
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Tài liệu Báo cáo khoa học: Restricted localization of proline-rich membrane anchor (PRiMA) of globular form acetylcholinesterase at the neuromuscular junctions – contribution and expression from motor neurons doc
... G4AChE in the< /b> tibialis was further confirmed by sucrose density gradi-ent analysis. The < /b> PRiMA antibody was able to deplete the < /b> G4form of AChE in the < /b> tibialis, but this was notobvious in the < /b> soleus ... [2]; the < /b> AChEHvariant produces a glycosylphos-phatidylinositol-linked dimer and is < /b> expressed in bloodcells; the < /b> AChETvariant is < /b> the < /b> only subunit expressedin the < /b> brain and muscle. The < /b> AChETsubunits ... cases, the < /b> brainenzyme was used as a control.We analyzed the < /b> localization of PRiMA in sectionsof tibialis and soleus muscle by immunohistofluores-cence. NMJs were visualized by labeling the < /b> post-synaptic...
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Tài liệu Báo cáo khoa học: Structural effects of a dimer interface mutation on catalytic activity of triosephosphate isomerase The role of conserved residues and complementary mutations pptx
... of the < /b> second subunit. The < /b> backbone NH group of R98 forms ahydrogen bond with the < /b> backbone CO of F102. Fur-thermore, the < /b> orientation of the < /b> side chain of the < /b> tworesidues brings the < /b> guanidinium ... [53]. The < /b> distribution of the < /b> / and w values of all other Lysresidues in the < /b> TIM structure is < /b> shown for < /b> comparison. The < /b> possible role of energetically unfavorable Rama-chandran disallowed conformations ... F102 of the < /b> other subunit. Thus, subunit dissociation in the < /b> case of the< /b> triple mutant Y74W* is < /b> expected to result in solventexposure of the < /b> buried Trp74 residue. Figure 4 summa-rizes the < /b> dependence...
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Tài liệu Báo cáo khoa học: Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface pdf
... differentiation, embryogenesisand morphogenesis [35]. TGF -b has five isoforms(TGF -b1 , 2, 3, 4 and 5), however, only TGF -b 1is< /b> known to alter BBB integrity. In an in vitro modelof the < /b> BBB, TGF -b1 treatment ... function of each respective organ.Brain vessels have extremely specialized characteris-tics that allow them to form the < /b> blood–brain barrier(BBB). The < /b> concept of the < /b> BBB was first suggestedmore than ... throughout the < /b> body by vasculogenesis [2]. The< /b> extracerebral vascular plexus is < /b> established by vasculo-genesis within the < /b> brain vasculature [2]. Early inembryogenesis, angioblasts invade the < /b> head...
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Tài liệu Báo cáo khoa học: An ecdysteroid-inducible insulin-like growth factor-like peptide regulates adult development of the silkmoth Bombyx mori docx
... Among these,bombyxins, a family of peptides produced by the < /b> brainof the < /b> silkmoth Bombyx mori, were the < /b> first to be dem-onstrated to have structural homology to vertebrateinsulins [7,8]. Bombyxin-II, ... important to establish the < /b> roles of BIGFLP in Bombyx develop-ment. However, such studies seem to be difficult in B. mori, for < /b> the < /b> following reasons: (a) it is < /b> impossible to remove the < /b> BIGFLP-producing ... and the < /b> solid squares at the < /b> bot-tom indicate ELISA-positive fractions. The < /b> immunoreactive fractionsbefore 30 min in (B) were combined and subjected to the < /b> nextchromatography step.N. Okamoto...
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