Báo cáo khoa học: Passage through the Golgi is necessary for Shiga toxin B subunit to reach the endoplasmic reticulum pptx

... is < /b> subverted by StxB when the < /b> Golgi < /b> pathway is < /b> unavailable. Clearly StxB cannot be present in the < /b> cytosol while membrane bound. This suggested that the < /b> toxin < /b> was able to dissociate from Gb3 while ... that Golgi < /b> passage < /b> is < /b> required for < /b> the < /b> toxins to enter the < /b> ER. In fact, an alternate pathway bypass...

Ngày tải lên: 16/03/2014, 04:20

... RecBC, RecBCD K177Q and RecB K29Q CD enzymes, and that the < /b> RecB motor is < /b> absolutely required for < /b> v recognition and RecA load- ing, while the < /b> RecD subunit is < /b> dispensable for < /b> motor activity of the < /b> ... with the < /b> regulatory v sequence and RecA recombinase in the < /b> cell [4,38,39]. Although all the < /b> subunits of RecBCD contribute to...

Ngày tải lên: 30/03/2014, 04:20

... identify the < /b> errors, if any, present in the < /b> former and to formulate some hypotheses about their causes. On the < /b> basis of these hy- potheses, the < /b> Tutor selects the < /b> next exercise which will test the < /b> ... has been thoroughly analyzed, the < /b> Tutor will possibly switch to other topics. 4. THE < /b> DOMAIN EXPERT The < /b> Domain Expert is...

Ngày tải lên: 01/04/2014, 00:20

... all been mapped to the < /b> N-domain of VCP (amino acids 1–199) [13,25,32,33]. As the < /b> VBM of Ube 4b is < /b> very similar to those of the < /b> above proteins, we hypothesized that Ube 4b should also bind to the < /b> ... necessary < /b> for < /b> VCP binding in Ube 4b, Atx-3 and Hrd1, but the < /b> influence of neigh- bouring amino acids is < /b> indicated both by the...

Ngày tải lên: 18/02/2014, 13:20

... recombinase Cre recombinase Probe A Probe B +/+ +/– –/– –/flox-hyg +/+ +/– 26.0 kb 11.4 kb 9.1 kb 9.4 kb 7.1 kb 2.7 kb –/flox-hyg Sm A BH Bg A Bg E Ss BH A Sm BH BH Ss Sm BH A Ss ... known to be targets for < /b> mitotic inhibition [30,31]. The < /b> regulatory mechanism of the < /b> ES cell cycle is < /b> still unclear. We are currently investigating whether PTB is <...

Ngày tải lên: 07/03/2014, 00:20

... then {remove OldEnd; concatenate NewEnd} where Tag is < /b> the < /b> tag of the < /b> wordform, OldEnd is < /b> the < /b> string that has to be removed from the < /b> end of the < /b> wordform, and NewEnd is < /b> the < /b> string that has to be ... information as part of the < /b> tags. For < /b> example, there are six tags for < /b> verbs in the < /b> Penn Treebank: VB...

Ngày tải lên: 08/03/2014, 21:20

... G 4 AChE in the < /b> tibialis was further confirmed by sucrose density gradi- ent analysis. The < /b> PRiMA antibody was able to deplete the < /b> G 4 form of AChE in the < /b> tibialis, but this was not obvious in the < /b> soleus ... [2]; the < /b> AChE H variant produces a glycosylphos- phatidylinositol-linked dimer and is < /b> expressed in blood cells; the < /b> AChE T variant...

Ngày tải lên: 18/02/2014, 08:20

... of the < /b> second subunit. The < /b> backbone NH group of R98 forms a hydrogen bond with the < /b> backbone CO of F102. Fur- thermore, the < /b> orientation of the < /b> side chain of the < /b> two residues brings the < /b> guanidinium ... [53]. The < /b> distribution of the < /b> / and w values of all other Lys residues in the < /b> TIM structure is < /b> shown for < /b> comp...

Ngày tải lên: 18/02/2014, 11:20

... differentiation, embryogenesis and morphogenesis [35]. TGF -b has five isoforms (TGF -b1 , 2, 3, 4 and 5), however, only TGF -b 1is < /b> known to alter BBB integrity. In an in vitro model of the < /b> BBB, TGF -b1 treatment ... function of each respective organ. Brain vessels have extremely specialized characteris- tics that allow them to form the < /b> blood–brain barrier (BBB). Th...

Ngày tải lên: 18/02/2014, 11:20

... Among these, bombyxins, a family of peptides produced by the < /b> brain of the < /b> silkmoth Bombyx mori, were the < /b> first to be dem- onstrated to have structural homology to vertebrate insulins [7,8]. Bombyxin-II, ... important to establish the < /b> roles of BIGFLP in Bombyx develop- ment. However, such studies seem to be difficult in B. mori, for < /b> the < /b> follow...

Ngày tải lên: 18/02/2014, 13:20