Báo cáo khoa học: Crystal structure of the parasite inhibito

Báo cáo khoa học: Crystal structure of the parasite inhibitor chagasin in complex with papain allows identiﬁcation of structural requirements for broad reactivity and speciﬁcity determinants for target proteases pptx

... cystatin B N-terminus). (B) Zoom -in view of the interactions of papain with loop L6 of chagasin and loop L2 of cystatin B. (C) Zoom -in view of the interactions of papain with loop L4 of chagasin ... afﬁnities for the enzyme. Comparisons of the chagasin papain complex with high-resolution structures of chagasin in complexes with cathe...

Ngày tải lên : 16/03/2014, 04:20

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Tài liệu Báo cáo khoa học: Crystal structure of importin-a bound to a peptide bearing the nuclear localisation signal from chloride intracellular channel protein 4 ppt

... determined the X-ray crystal structure of a truncated form of importin-a lacking the importin-b binding domain, bound to a CLIC4 NLS peptide. The NLS peptide binds to the major binding site in an extended ... cargo binding sites, referred to as the major and minor binding sites [1]. These sites are located in the concave face of the protein near regions of inva...

Ngày tải lên : 14/02/2014, 19:20

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Tài liệu Báo cáo khoa học: Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 – insights into the enzyme mechanism and stability pdf

... residues involved in the binding of the metal cofactor. ApeSODs in different forms were superimposed with the least square ﬁt of Ca atoms of the residues in the range 10–200. ApeSOD and P. shermanii ... metal-binding site at the interface of the two domains, which consists of four side chains: two (His31 and His79) from the N-terminal domain and two (As...

Ngày tải lên : 14/02/2014, 22:20

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Tài liệu Báo cáo khoa học: Crystal structure of Klebsiella sp. ASR1 phytase suggests substrate binding to a preformed active site that meets the requirements of a plant rhizosphere enzyme doc

... RHGXRXP and HD, and hydrolyze metal-free phytate with pH optima in the acidic range. They consist of two domains, a large a ⁄ b domain and a small a domain with the catalytic site at the interface of ... protein. The atomic displacement factors of the PhyK structure are smaller for the a ⁄ b domain than for the a domain. This has also been observed for...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Crystal structure of the catalytic domain of DESC1, a new member of the type II transmembrane serine proteinase family pptx

... unlikely, therefore, that the SEA domain would directly in uence the binding of either substrates or inhibitors into the active site cleft of the DESC1. Instead, because SEA domains are proposed ... crystal structure data on the remaining subgroups of the HAT ⁄ HAT-like ⁄ DESC and corin subfamilies exists. We therefore cloned, expressed and puriﬁed the serine pr...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Crystal structure of the BcZBP, a zinc-binding protein from Bacillus cereus doc

... role in the enzymatic reaction which will be discussed later. The structure of the active site, the type of protein ligands, the zinc-binding motif, the presence of a water Fig. 3. Structure of the ... that the metal must be intrinsically contained in the protein. The structure of the active site is illustrated in Fig. 3. The zinc ion is tetrahedr...

Ngày tải lên : 19/02/2014, 00:20

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Tài liệu Báo cáo khoa học: Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid doc

... orientation of the aminopyrimidine ring, are conserved in all ThDP-dependent enzymes. One of these, the hydrogen bond between the N1¢ atom of the pyrimidine ring of ThDP and the side chain of an invariant ... binds four molecules of the cofactors ThDP and Mg 2+ . The ThDP binding sites are located in narrow clefts at the interfaces formed by the PYR domai...

Ngày tải lên : 20/02/2014, 11:20

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Báo cáo khoa học: Crystal structure of salt-tolerant glutaminase from Micrococcus luteus K-3 in the presence and absence of its product L-glutamate and its activator Tris pdf

... determined the F structure containing the truncated region of the C-terminal domain; however, we failed to determine the structure of the intact glutaminase because the crystals exhib- ited heavy twinning. ... conformations of the regions at 100-105 and 303-309 aa in the N form, and we investi- gated the following points. First, these areas are not involved...

Ngày tải lên : 06/03/2014, 09:22

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Báo cáo khoa học: Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima docx

... spheres) and the substrate ( D-inositol-1-phosphate, gray). The model of the TM1415 crystal form 1 is in purple and the crystal form 2 in green (including the tartrate molecule). The conformational ... containing the active site. The lower domain is reminiscent of the AMP- binding domain of eukaryotic FBPases (supplementary Fig. S2). The active site i...

Ngày tải lên : 16/03/2014, 11:20

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Báo cáo khóa học: Crystal structure of the chi:psi subassembly of the Escherichia coli DNA polymerase clamp-loader complex doc

... responsible for the stable interaction of single-stranded DNA, SSB and the v:w complex. The N-terminal segment of w is a possible linker between v:w and the clamp-loader In the crystals of v:w, the N-terminal ... that the v:w unit is linked to the single-stranded DNA-binding protein via the distal surface of v. The base of the clamp-loader complex ha...

Ngày tải lên : 16/03/2014, 16:20

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