Báo cáo khoa học: Parkin deﬁciency disrupts calcium homeosta

Báo cáo khoa học: Parkin deﬁciency disrupts calcium homeostasis by modulating phospholipase C signalling pdf

... carbachol (100 lm), an agonist of muscarinic acetylcholine receptors that speciﬁcally activates PLCb but not PLCc. Treatment of cells with carbachol gave a rapid increase in [Ca 2+ ] i . Peak increases ... cell death induced by 6OHDA. Disrupted Ca 2+ homeostasis and ⁄ or other parkin- related functions ultimately alter PKCa protein levels. A. Sandebring et al. Parkin deﬁciency disru...

Ngày tải lên : 16/03/2014, 03:20

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Tài liệu Báo cáo khoa học: RMI1 deﬁciency in mice protects from diet and genetic-induced obesity pptx

... proliferation, and is regulated by several cell cycle-related proteins. RMI1 is known to be a cell cycle-related molecule with the ability to activate the cell-cycle checkpoint machinery [10], and siRNA ... die by embryonic day 13.5 [22,23]. Bloom’s syndrome is a rare recessive genetic disorder characterized by dwarﬁsm, telangiec- tatic erythema, immune deﬁciency and a predisposition...

Ngày tải lên : 16/02/2014, 09:20

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Tài liệu Báo cáo khoa học: Parvalbumin deficiency in fast-twitch muscles leads to increased ‘slow-twitch type’ mitochondria, but does not affect the expression of fiber specific proteins doc

... 204 RT-PCR GAPDH GAG CTG AAC GGG AAG CTC ACT GG GTG AGG GAG ATG CTC AGT GTT GG 429 RT-PCR CaN AGTAACAATTTTCAGTGCTCCAAAC AATATACGGTTCATGGCAATACTGT 205 RT-PCR CaMKII CTACCCCGGCGCTGGAGTCAAC TCAGATGTTTTGCCACAAAGAGGTGCCTCCT ... CTACCCCGGCGCTGGAGTCAAC TCAGATGTTTTGCCACAAAGAGGTGCCTCCT 530 RT-PCR COX I CGA GCT TGC TTT ACA TCA GCC TGT GTC ATC TAG GGT GAA GCC 317 Northern blot COX Vb GGC TTC AAG GTT ACT...

Ngày tải lên : 19/02/2014, 07:20

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Báo cáo khoa học: Frataxin deﬁciency causes upregulation of mitochondrial Lon and ClpP proteases and severe loss of mitochondrial Fe–S proteins pot

... mitochondria-encoded genes in the heart of control versus MCK mutant mice at 3, 5 and 10 weeks of age. Cytb, cytochrome b; COX, cyclo-oxygenase. Mitochondrial subunits mRNA fold change difference ... deﬁcit in mitochondrial Fe–S cluster enzyme activities is an early event in FRDA disease, followed by rapid cardiac dysfunction, whereas abnor- mal iron accumulation within the mitochondria occ...

Ngày tải lên : 23/03/2014, 06:20

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Tài liệu Báo cáo khoa học: Altered inactivation pathway of factor Va by activated protein C in the presence of heparin doc

... thereby facilitating its cleavage by APC. Because cleavage at Arg506 by the 37-loop APC mutants is unaffected by heparin and as the activity of FVa in the prothrombinase complex was not inﬂuenced ... human blood coagulation factor V by molecular modeling. Protein Sci. 7, 1317–1325. 29. Honig, B. & Nicholls, A. (1995) Classical electrostatics in biology and chemistry. Science 268,...

Ngày tải lên : 19/02/2014, 13:20

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Báo cáo khoa học: Acidic extracellular pH increases calcium inﬂux-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma pot

... (18 cycles, 555 bp) 5¢-CAT CGT GGG CCG CTC TAG GCA CCA AG-3¢ (forward) and 5¢-GCA CAG CTT CTC TTT GAT GTC ACG CAC-3¢ (reverse). PCR thermal conditions used were: aSMase ⁄ smpd1 and mmp-9,94 C for ... CCA GAG CTT ATC-3¢ (forward) and 5¢-TCC TCA AAG AGA TGG ACG-3¢ (Reverse); mmp-9 (28 cycles, 471 bp), 5¢-GTA TGG TCG TGG CTC TAA GC-3¢ (forward) and 5¢-AAA ACC CTC TTG GTC TGC GG-3¢ (reverse); b-...

Ngày tải lên : 07/03/2014, 09:20

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Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx

... mitochondrial membrane potential; [Ca 2+ ] c , cytosolic calcium concentration; [Ca 2+ ] m , mitochondrial matrix free -calcium concentration; CsA, cyclosporin A; IFM, interfribillar mitochondria; ... 8179–8184. 45 Tate CA, Bick RJ, Chu A, Van Winkle WB & Entman ML (1985) Nucleotide speciﬁcity of cardiac sarcoplasmic reticulum. GTP-induced calcium accumulation and GTPase activity...

Ngày tải lên : 16/03/2014, 22:20

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BÁO CÁO KHOA HỌC CHUYÊN ĐỀ SỞ HŨU CHUNG HỢP NHẤT TRONG QUAN HỆ HÔN NHÂN

... vợ chồng đư c thừa kế chung ho c đư c tặng cho chung: chủ sở hữu cho, tặng chung c vợ và chồng, phụ thu c ý chí c a chủ sở hũu 05- và những tài sản kh c mà vợ chồng thoả thuận là tài sản chung: ... Vi c chia tài sản chung đư c giải quyết theo c c nguyên t c sau đây: a) Tài sản chung c a vợ chồng về nguyên t c đư c chia đôi, nhưng c xem xét hoàn c nh c a mỗi bên, tình trạng...

Ngày tải lên : 10/04/2013, 11:57

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Tài liệu Báo cáo khoa học: Vấn đề thưởng thức văn học nghệ thuật của công chúng hiện nay docx

... thdi, eai gdc cua tha'm my la cai cao thugng, cii cao cl. Am nhac thinh phdng bpc Id eai eao cl la net ldn nhat cua cac ea khiie each mang va khang chien. Ngay ... eiiu cdng chiing nhu viee nghien ciiu thi trubng cua nganh khoa hpc marketing trong kinh te. Vai trb ciia cdng chiing dan ed vai trb tich cue nguge trd lai khau sang tie. Cd...

Ngày tải lên : 18/02/2014, 03:20

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Tài liệu Báo cáo khoa học: Disulﬁde bridge regulates ligand-binding site selectivity in liver bile acid-binding proteins ppt

... enterocytes. Abbreviations BA, bile acid; BABP, bile acid-binding protein; CA, cholate; CDA, chenodeoxycholate; CSP, chemical shift perturbation; GCA, glycocholic acid; GCDA, glycochenodeoxycholic ... cooperativity [4–6]. I-BABP, unlike L-BABP, displays remarkable site selectivity for the two main glycoconjugated BAs, glycocholic acid (GCA) and glycochenodeoxycholic (GCDA). A number of factor...

Ngày tải lên : 18/02/2014, 06:20

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