Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot

... government works Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases Tara L. Davis1,2, John R. Walker1, Abdellah Allali-Hassani1, Sirlester ... member of aunique branch of the kinome in which downstream signaling occurs in bothligand- and receptor- expressing cells. Consequently, the ephrins and ephrin receptor tyrosine kinases often ... the +2 plays an impor-tant role in reordering the structure of the region of the C-terminal lobe that interacts with these substrates.In the absence of the phosphate group, the side chainof...

Tài liệu Báo cáo khoa học: "ModelTalker Voice Recorder – An Interface System for Recording a Corpus of Speech for Synthesis" ppt

... recorded, the user rece-ives feedback on the overall quality of the utter-ance. Specifically, the user receives feedback on the pitch, the overall amplitude, and the pronuncia-tion of the recording. ... smoother, more natural sounding synthesis, but requires many hours of recording, often by a trained professional. The recording process is usually supervised, and the recordings are often hand-polished. ... within an acceptable range. This feedback mechan-ism also helps to eliminate cases in which the sys-tem is unable to accurately track the pitch of an utterance. In these cases, the utterance...

Báo cáo khoa học: Two short protein domains are responsible for the nuclear localization of the mouse spermine oxidase l isoform pdf

... havecoevolved in mammalian SMOs and that they maycooperate in targeting the mSMOl isoform to the nuc-leus. By means of transient expression of the deletionmutant, mSMOlD, in the murine neuroblastoma ... Spd,3-aminopropanal and H2O2[7–9].Analysis of the expression of the mouse SMO gene(mSMO), encoding at least nine splice variants, as wellas biochemical characterization of the canonical alfaisoform ... transientlytransfected cells, we conﬁrmed a nuclear localization for the mSMOl isoform (Fig. 4).Taken together, these results consistently substanti-ate the hypothesis that these two structural...

Báo cáo khoa học: "TENSE GENERATION IN AN INTELLIGENT TUTOR FOR FOREIGN LANGUAGE TEACHING: SOME ISSUES IN THE DESIGN OF THE VERB EXPERT" pot

... point, the Student Modeler compares the answer of the student with that of the expert in order to identify the errors, if any, present in the former and to formulate some hypotheses about their ... On the basis of these hy- potheses, the Tutor selects the next exercise which will test the student on the critical aspects pointed out so far and will allow the Modeler to gather further ... example, the kind of clause (main, coordinate, subordinate), whether the clause has a verb to be solved, the voice and form of the clause, the kind of event described by the clause, the time...

Tài liệu Báo cáo khoa học: Top-down MS, a powerful complement to the high capabilities of proteolysis proteomics pdf

... problem for MS ⁄ MS of either the peptides for the bottom-up approach or of the proteins for the top-down approach is that backbone dissocia-tion techniques such as CAD or IRMPD can alsocleave off ... selectedor tailored for the speciﬁc PTM. In the biosynthesis of NAD, the enzyme 3-hydroxyanthranilate-3,4-dioxygen-ase (HAD) catalyzes the oxidative ring opening of 3-hydroxyanthranilate, which, ... and potent HAD inhibitors. Tocheck for covalent modiﬁcations of the enzyme, the effect of the inhibitor on the molecular mass value of HAD was measured; instead of an adduct increase, orno change,...

Tài liệu Báo cáo khoa học: Oxidized elaﬁn and trappin poorly inhibit the elastolytic activity of neutrophil elastase and proteinase 3 pdf

... oxida-tion of M51 and M89 of M25L elaﬁn and M63L trap-pin, respectively. On the other hand, oxidation of M25L elaﬁn and M63L trappin did not signiﬁcantlyaffect their Ki for NE (Table 2). We therefore ... elaﬁn and trappinElaﬁn and the inhibitory domain of trappin each havetwo methionine residues (M25 and M51 for elaﬁn, andM63 and M89 for trappin). M25 and M63 are the P1¢residues of the inhibitors’ ... bacteria and destroyforeign substances in the phagolysosome of polymor-phonuclear neutrophils. The membrane of these phago-cytes contains an NADPH oxidase, which transformsmolecular oxygen into the...

Tài liệu Báo cáo khoa học: "Using adaptor grammars to identify synergies in the unsupervised acquisition of linguistic structure" docx

... to them(e.g., “to” is often analysed as the sufﬁx of verbssuch as “have”, “want” and “like”, while “me” is of- ten analysed as a sufﬁx of verbs such as “show” and“tell”), but they lower the ... grammar can learn the possibleonset and coda clusters, rather than requiring themto be stipulated in the grammar.In the unigram syllable adaptor grammar shownin Figure 7, Consonant expands to any ... balls of color x. We samplea distribution from DP(α, H) by repeatedly drawinga ball at random from the urn and then returning itplus an additional ball of the same color to the urn.In an adaptor...

Báo cáo khoa học: Mycobacterium tuberculosis possesses a functional enzyme for the synthesis of vitamin C, L-gulono-1,4-lactone dehydrogenase doc

... University of Brussels, BelgiumVitamin C (l-ascorbic acid; L-AA) is an importantmetabolite of plants and animals. It functions as an antioxidant (or pro-oxidant), an enzyme cofactor, an effector of ... cell proliferationand apoptosis [3]; activation of the epithelial cysticﬁbrosis transmembrane conductance regulator chloridechannel [4] and of surfactant production in humanlungs [5]; macrophage ... proposed for the plant Hsc70.3 cognate heat-shock protein and anothervitamin C-related enzyme, the GDP-mannose-3¢,5¢-epimerase [9]. The presence of multiple GST-contain-ing bands of about...

Báo cáo khoa học: "Some Comments on Algorithm and Grammar in the Automatic Parsing of Natural Languages" ppt

... any of several grammars of a certain type. The type of grammar has to be specified very precisely by means of a grammar- rule format. These grammars can be written in the form of tables of ... grammars written in the form of appropriate tables of rules. The paper raises the question of the increasing complexity of the tables when more than the most elementary natural-language con- ditions ... program is the adequate recognition of the boundaries and functions of syntac- tic units. On the basis of this recognition, automatic translation on a sentence-by-sentence rather than a word-by-word...

Báo cáo khoa học: Nautilin-63, a novel acidic glycoprotein from the shell nacre of Nautilus macromphalus doc

... selected for fragmentation and dynamically excluded for 30 s with± 50 mmu mass tolerance. The collision energy was set by the software according to the charge and mass of the precur-sor ion. The ... understand the molecular mechanism that controls the formation of the shell nacreouslayer, we have investigated the biochemistry of Nautilin-63, one of the main nacre matrix proteins of the cephalopod Nautilus ... producedextracellularly by the calcifying epithelium of the man-tle. The shell layers are composites of calcium carbon-ate crystals, which are densely packed together with an array of biomacromolecules that form...

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