Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot

... government works Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases Tara L. Davis 1,2 , John R. Walker 1 , Abdellah Allali-Hassani 1 , Sirlester ... member of a unique branch of the kinome in which downstream signaling occurs in both ligand- and receptor- expressing cells. Consequently, the ephrins and ephr...

Ngày tải lên: 16/03/2014, 02:20

... recorded, the user rece- ives feedback on the overall quality of the utter- ance. Specifically, the user receives feedback on the pitch, the overall amplitude, and the pronuncia- tion of the recording. ... smoother, more natural sounding synthesis, but requires many hours of recording, often by a trained professional. The recording process is usually supervised, and...

Ngày tải lên: 20/02/2014, 09:20

... have coevolved in mammalian SMOs and that they may cooperate in targeting the mSMOl isoform to the nuc- leus. By means of transient expression of the deletion mutant, mSMOlD, in the murine neuroblastoma ... Spd, 3-aminopropanal and H 2 O 2 [7–9]. Analysis of the expression of the mouse SMO gene (mSMO), encoding at least nine splice variants, as well as biochemical characte...

Ngày tải lên: 07/03/2014, 17:20

... point, the Student Modeler compares the answer of the student with that of the expert in order to identify the errors, if any, present in the former and to formulate some hypotheses about their ... On the basis of these hy- potheses, the Tutor selects the next exercise which will test the student on the critical aspects pointed out so far and will allow th...

Ngày tải lên: 01/04/2014, 00:20

... problem for MS ⁄ MS of either the peptides for the bottom-up approach or of the proteins for the top-down approach is that backbone dissocia- tion techniques such as CAD or IRMPD can also cleave off ... selected or tailored for the specific PTM. In the biosynthesis of NAD, the enzyme 3-hydroxyanthranilate-3,4-dioxygen- ase (HAD) catalyzes the oxidative ring openin...

Ngày tải lên: 18/02/2014, 16:20

... oxida- tion of M51 and M89 of M25L elafin and M63L trap- pin, respectively. On the other hand, oxidation of M25L elafin and M63L trappin did not significantly affect their K i for NE (Table 2). We therefore ... elafin and trappin Elafin and the inhibitory domain of trappin each have two methionine residues (M25 and M51 for elafin, and M63 and M89 for trappin). M25 and M63 are the...

Ngày tải lên: 19/02/2014, 07:20

... to them (e.g., “to” is often analysed as the suffix of verbs such as “have”, “want” and “like”, while “me” is of- ten analysed as a suffix of verbs such as “show” and “tell”), but they lower the ... grammar can learn the possible onset and coda clusters, rather than requiring them to be stipulated in the grammar. In the unigram syllable adaptor grammar shown in Figure 7, Consona...

Ngày tải lên: 20/02/2014, 09:20

... University of Brussels, Belgium Vitamin C (l-ascorbic acid; L-AA) is an important metabolite of plants and animals. It functions as an antioxidant (or pro-oxidant), an enzyme cofactor, an effector of ... cell proliferation and apoptosis [3]; activation of the epithelial cystic fibrosis transmembrane conductance regulator chloride channel [4] and of surfactant production in...

Ngày tải lên: 07/03/2014, 12:20

... any of several grammars of a certain type. The type of grammar has to be specified very precisely by means of a grammar- rule format. These grammars can be written in the form of tables of ... grammars written in the form of appropriate tables of rules. The paper raises the question of the increasing complexity of the tables when more than the most elem...

Ngày tải lên: 07/03/2014, 18:20

... selected for fragmentation and dynamically excluded for 30 s with ± 50 mmu mass tolerance. The collision energy was set by the software according to the charge and mass of the precur- sor ion. The ... understand the molecular mechanism that controls the formation of the shell nacreous layer, we have investigated the biochemistry of Nautilin-63, one of the main...

Ngày tải lên: 22/03/2014, 16:20