Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation pptx

... preventing the generation of potentially harmful semiquinones. In recent years, an additional role of quinone reductases as regulators of proteaso- mal degradation of transcription factors and possibly ... flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation Sonja Sollne...

Ngày tải lên: 16/03/2014, 02:20

... was identi- fied as an intermediate in the formation of 64PPs [64,69]. This putative repair mechanism of (6-4) pho- tolyases requires one histidine acting as a proton acceptor and the other as ... Universita ¨ t Berlin, Germany Introduction Ultraviolet light (k £ 300 nm) is known to induce the formation of covalent linkages between pairs of thy- mine and cytosine bases in c...

Ngày tải lên: 16/03/2014, 02:20

... MINIREVIEW New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin Federico Forneris 1 , Elena Battaglioli 2 , Andrea Mattevi 1 and Claudia Binda 1 1 ... flavin amine oxidases, including the overall fold of the amine oxidase domain region and details in the active site that are relevant for amine substrate oxidation. Abbreviations AOD, am...

Ngày tải lên: 16/03/2014, 02:20

... activation of caspase 3 in human non- small cell lung cancer cell line PC-9. To investigate the signaling route by which AG1478 induced apoptosis, we examined the activation of c-Jun N-terminal kinase ... FEBS 1255 kinase (ERK) 1 ⁄ 2 plays an essential role in EGF- induced cell growth; and the phosphatidylinosi- tol 3-kinase (PtdIns3K) pathway is also important for cell...

Ngày tải lên: 18/02/2014, 13:20

... lineage of plants. ClpP genes are also found in Cyanobacteria [22] and in the genome of the Cyanophora cyanelle, an ancestral chloroplast. In the green alga Chlamydomonas reinhardtii and in vascular ... parvum, an Apicomplexan that has lost its apicoplast, also has lost both ClpP and ClpR [38,39]. In any event, apicomplexan ClpP appears as an interes- ting target for t...

Ngày tải lên: 16/03/2014, 23:20

... change of the Fe(II) spin state and no replacement of any of the two axial ligands of the iron, His18 or RNO, by an amino acid side-chain of the antibody protein. Binding site topology of antibody ... containing sulfur were chosen as substrates, as they play an important role in medicine and agriculture. It has been reported that  10– 15% of medicinal and veterinary...

Ngày tải lên: 19/02/2014, 12:20

... temperature of the solution was maintained at 25 °C, the reaction mixture was i ncubated for 10 min prior to spectroscopic measurements. Cyanide binding The association rate of cyanide to haem was observed ... Met95 Table 2. Cyanide binding rates, r edox potentials and auto-oxidation rates of the Asp40Ala and Asp40Asn mutants of Ec DOS PAS. Cyanide binding rate, experimental errors...

Ngày tải lên: 19/02/2014, 16:20

... E119 can act as a general base for deprotonation of intermediates, as proposed by Berthold et al. [3,4] for OfODC. The tyrosine residues 118 and 478 (the latter in an uncom- mon side-chain conformation) ... main chain nitrogens of residues I322 and I303 interact with nitrogen atoms of the adenine ring and the c-carboxyl group of the side chain of residue D302, the d and...

Ngày tải lên: 06/03/2014, 11:20

... Cunningham JM, Massou- lie ´ J & Sanes JR (1999) Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. J Cell Biol ... domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase Dong Liang 1,2 , Jean-Philippe Blo...

Ngày tải lên: 07/03/2014, 03:20

... replacement has only been observed in E. focardii and in the psychrotolerant E. crassus [34, present study]. By contrast, the similar substitution of alanine for arginine 72 in the c-tubu- lins of T. ... focardii c-tubulins in total cell extracts and in subfractions enriched in basal bodies or in micronuclei using anti- (human c-tubulin) and anti- c-T1 sera. Figure 7 sho...

Ngày tải lên: 07/03/2014, 04:20