Báo cáo khoa học: New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin pot

... MINIREVIEW New roles of flavoproteins in molecular cell biology: Histone demethylase LSD1 and chromatin Federico Forneris 1 , Elena Battaglioli 2 , Andrea Mattevi 1 and Claudia Binda 1 1 ... branches off in MAO A and B (Fig. 3A). The SWIRM domain is a motif com- monly found in chromatin enzymes and is responsible for protein–protein and DNA–protein int...

Ngày tải lên: 16/03/2014, 02:20

... FEBS 4303 MINIREVIEW New roles of flavoproteins in molecular cell biology: Blue-light active flavoproteins studied by electron paramagnetic resonance Erik Schleicher 1 , Robert Bittl 2 and Stefan ... other proteins involved in intracellular signaling or localiza- tion [24,25]. In photolyases and cryptochromes, radicals and radical pairs play a prominent role in...

Ngày tải lên: 16/03/2014, 02:20

... are involved in recognition of the polyubiquitinated protein substrates, unfolding of the condemned protein [24], removing ubiquitin chains for recycling [25,26] and opening an axial gate into ... compilation ª 2009 FEBS MINIREVIEW New roles of flavoproteins in molecular cell biology: An unexpected role for quinone reductases as regulators of proteasomal degradation...

Ngày tải lên: 16/03/2014, 02:20

Ngày tải lên: 22/03/2014, 16:20

... of the Fe(II) spin state and no replacement of any of the two axial ligands of the iron, His18 or RNO, by an amino acid side-chain of the antibody protein. Binding site topology of antibody 3A3 Figure ... the binding of MP8 occurred through interactions of its carboxylate substituents with amino acids of the antibody, and that the protein provided a partial steric hindra...

Ngày tải lên: 19/02/2014, 12:20

... he redox potential of the haem, rate constants o f CO, O 2 and CN b inding to haem, and CD spectra in the Soret region [15–18], suggesting that this residue is critical for maintaining the electronic ... side and/ or structure in t erms of cyanide binding in the Fe(III) complex. Redox potentials The redox state of haem is related to the PDE activity of Ec DOS, since it is a...

Ngày tải lên: 19/02/2014, 16:20

... However, in the case of Bb, the cellular activity was decreased and secretion was increased, suggesting that the presence of this cys- teine retains the enzyme intracellularly. In case of Aa, the cellular ... acetylthiocholine. The rates of hydrolysis of acetylthiocholine and butyrylthiocholine (at 6 mm) by BChE were approximately 14% and 24% of the rate of hydrolysis...

Ngày tải lên: 07/03/2014, 03:20

... also be involved. In multicellular organisms, GATA-binding factors play critical roles in development, including cell- fate specification, regulation of differentiation, and control of cell proliferation ... second intron included nucleotides 210–253 in each gene. Excluding introns and stop codons, the c-T1 and c-T2 coding regions were each 1383 bp in length and predic...

Ngày tải lên: 07/03/2014, 04:20

... the remaining acid and flurbiprofen as an internal stand- ard using reversed phase HPLC analysis. According to the Lineweaver–Burk plot, the K m and V max values for racemic ketoprofen were 0.22 mm and ... not investigated in detail and only three kinds of substrate, ibuprofen, fenoprofen, and flurbi- profen, were examined [16]. With these substrates, flurbiprofen could not be used...

Ngày tải lên: 07/03/2014, 10:20

... to 30 kDa in size. Subunits of all known GST structures exhibit a two-domain fold, the N-terminal domain and C-terminal domain, including the highly conserved GSH-binding site (G-site) and the ... hypothesis. Experimental procedures Molecular cloning of sweet orange GSTU1 and GSTU2 Cloning of sweet orange GSTU1 and GSTU2 genes and their transfer into the expression vector...

Ngày tải lên: 15/03/2014, 09:20