Báo cáo khoa học: Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 in HepG2 cells pptx

... compilation ª 2009 FEBS 3769 Tumour necrosis factor-a attenuates insulin action on phosphoenolpyruvate carboxykinase gene expression and gluconeogenesis by altering the cellular localization of Foxa2 ... prevention of the effect of insulin on Foxa2 localization and lead- ing to the abrogation of insulin inhibition of gluconeo- ge...

Ngày tải lên: 16/03/2014, 02:20

... nutrient-starved cells [26], and conversion of GTP to ppGpp and pppGpp during the stringent response to amino acid starvation [25]. A reduction in intracellular GTP without a corresponding decline in uridine ... (ATCase), the enzyme encoded by pyrB, the third cistron of the operon, provided a convenient measure of operon expression in such experiments. Inclusion...

Ngày tải lên: 16/03/2014, 06:20

... distribution, changing the number of topics k in the following, k = 5, k = 10, k = 20, k = 50, k = 100, and k = 200. Next, the number of topics is fixed based on the result of the first process, and then ... number of extracted sentences is the same as used in TSC3. Precision is an evaluation measure which indicates the ratio of the number of correct senten...

Ngày tải lên: 23/03/2014, 16:20

... days of incubation the cells were lyzed and analyzed by Western blotting. Construction of expression vectors Blunt end cDNAs of either bovine furin or rat PC7 were cloned into pIRES1hyg (Clontech), ... degradation, we examined whether overexpression of functionally active furin in LoVo cells restores the effect of PMA on the degradation of mature TACE. Therefor...

Ngày tải lên: 08/03/2014, 02:20

... including the in ammatory response, immunity and apoptosis. Some of the responses of TNF-a are mediated by caspase-1, which is involved in the production of the pro -in ammatory cytokines interleukin- 1b, ... lipopolysaccharide- induced septic shock and are also defective in the production of the active cytokines interleukin-1b, interleukin-18 and interleukin-...

Ngày tải lên: 16/03/2014, 05:20

... ligand binding [31]. The intracel- lular part of TNFR1 contains a protein–protein inter- action region called the death domain [32]. After ligand binding to the TNFR1, silencer of death domain ... TNFR2 signaling [29]. Trimerization of TNFR2 takes place upon binding of TNF, which leads to the recruitment of TRAF2 to the intracellular TRAF-binding motif and consequently...

Ngày tải lên: 28/03/2014, 23:20

... validated by a clinical pharmacist. The registration of different classes of MPE was done according to the National Coordinating Council for Medication Error Reporting and Prevention guidelines. An independent ... panel, consisting of one clinical pharmacist, not involved in the registration part of the study, and two inten- sive care specialists, evaluated independent...

Ngày tải lên: 25/10/2012, 10:39

... combination of a potent quinolone combined with clindamycin. This strategy is commonly followed in our facility for infection of unknown origin and generally corresponds to the guidelines of the ... (29%), and head (18%). Two-thirds of patients had combined injuries to the thorax (for instance, pneumo-/hemopneumothorax), including intrapulmonary contusions and lesioning,...

Ngày tải lên: 25/10/2012, 10:41

... oligomerization and, by extension, amyloid formation will be considered below, including the role of 3D domain-swapping and proline isomerization. The energetics of domain-swapping Intramolecular and intermolecular ... different conformational preferences of residues in aqueous solution. Moreover, the additional modulation of screening by changing the local environm...

Ngày tải lên: 14/02/2014, 18:20

... possible reason might be that the additional interaction between its adenine moiety and the enzymes’s adenine-binding pocket stabilizes the interaction between the enzyme a and b subunits. In contrast, ... in the activation of the enzymeÆcyanocobalamin complex. This result is consistent with the lack of specific interaction with the adenine ring of ADP in the...

Ngày tải lên: 15/02/2014, 01:20