Báo cáo khoa học: Modular kinetic analysis reveals differences in Cd2+ and Cu2+ ion-induced impairment of oxidative phosphorylation in liver pot

... FEBS Metal-induced impairment of mitochondrial function J. Ciapaite et al. Modular kinetic analysis reveals differences in Cd 2+ and Cu 2+ ion-induced impairment of oxidative phosphorylation in liver Jolita ... Cd 2+ on the kinetics of the CoQ-oxidizing module (A) and CoQ-reducing module (B). Effect of Cu 2+ on the kinetics of the CoQ-oxidizing module (...

Ngày tải lên: 16/03/2014, 02:20

... (PKA)-mediated phosphorylation of CREB at Ser133 [19]. Ser133 phos- phorylation of CREB, in turn, promotes recruitment of the coactivator paralogs CREB-binding protein and p300 via a kinase-inducible domain in CREB, ... were normalized to b-actin or porin (for mitochondrial protein). Chromatin immunoprecipitation Treated cells were crosslinked using 1% formaldehyde for 20 min a...

Ngày tải lên: 16/03/2014, 01:20

... (2009) Modular kinetic analysis reveals differences in Cd 2+ and Cu 2+ ion-induced impairment of oxidative phosphorylation in liver. FEBS J 276, 3656–3668. 15 Ainscow EK & Brand MD (1999) Internal ... determined from data obtained by changing the concentration of the linking intermediate and measuring the corresponding rates of the modules (i.e. from modul...

Ngày tải lên: 14/03/2014, 23:20

... certain in u- enza strains do not agglutinate cRBCs, using specific human-adapted in uenza hemagglutinins as examples. Finally, recent understanding of the role of various glycan structures in high ... FEBS 1699 of RBCs occurs when the addition of a limiting amount of virus results in ‘crosslinking’ of RBCs through binding of multiple RBCs to HAs present on a single virus;...

Ngày tải lên: 14/02/2014, 19:20

... validated in vitro andusedtoexamine the branch-point kinetics in detail and to obtain insights into the kinetic controls of methionine and threonine synthesis in plants. The branch-point between ... irreversible and inhibited by inorganic phosphate. The modelling procedure included an examination of the kinetic links, the determin- ation of the operating conditions in...

Ngày tải lên: 20/02/2014, 02:21

... phemes in terminology on the basis of a small sample. 1 Introduction In computational linguistics, the interest in ter- minological applications such as automatic term extraction is growing, and ... which is not of much interest. The more important and interesting is the actual transition of the mean frequencies within a realistic range of N, because the size of a...

Ngày tải lên: 20/02/2014, 18:20

... as being some combination of the following: (a) production of redox potential in the form of NADPH; (b) production of glycolytic intermediates, reducing the demand put upon phosphofructokinase; ... in the complete absence of experimental error. The disadvantages of kinetic modelling stem primarily from the uncertainty in the definition of the kinetics, both in terms of...

Ngày tải lên: 20/02/2014, 23:20

... may explain the differences in drug efficacy between the mono- intercalating anthracyclines and the more sequence-selective bisanthracycline WP631. To gain further insight into the causes of the distinct ... AnnexinV-Fluos staining and low propidium-iodide staining are clearly more abundant after treatment with daunorubicin (D). Fig. 4. Quantitative determination of the uptake of...

Ngày tải lên: 20/02/2014, 23:20

... both penicillin G and ampicillin. Role of arginine residues in controlling cosubstrate selectivity The results highlight the essential nature of an arginine residue in the 2-oxoglutarate binding site in ... insights into how the oxidation of 2-oxoglutarate (the cosubstrate) and the penicillin substrate are coupled. R258 and S260 are located in the 2-OG binding pocket and...

Ngày tải lên: 20/02/2014, 23:20

... aspect of growth and development in plants. Sev- eral recent discoveries in auxin biology, including the identification of F-box proteins as auxin receptors, have contributed to our understanding of ... the aim of gaining some insight into the mechanism of auxin action. A comparison of expression profiles of untreated and auxin-treated rice seedlings identified 315 probe se...

Ngày tải lên: 07/03/2014, 01:20