Báo cáo khoa học: Regulation of secretases by all-trans-retinoic acid pot

... et al. Regulation of secretases by retinoic acid FEBS Journal 276 (2009) 2645–2655 ª 2009 The Authors Journal compilation ª 2009 FEBS 2655 Regulation of secretases by all-trans-retinoic acid Anna ... 42 levels is mainly achieved by modulation of secretases, namely by the induction of a-secretase activity, by inhibition of b -secretases and ⁄ or c -secretase...

Ngày tải lên: 16/03/2014, 01:20

... in the regulation of epithelial cell death. The degradation of DNp63a by TNF-a was delayed when cells were treated with nuclear factor-jB inhib- itors, whereas the induction of apoptosis by TNF-a ... destabilizes DNp63a by both proteasomal and caspase-dependent degradation pathways. The degradation of DNp63a by TNF-a was attenuated by inhibition of NF-jB, sug- gesting th...

Ngày tải lên: 16/03/2014, 06:20

... cleavage of procaspase-8 and procaspase-10, and subsequent downstream activa- tion of the extrinsic and intrinsic pathways of apoptosis [4]. Despite the considerable interest raised by the poten- tial ... cells. PIs potently induce expression of DR5 in glioma cells To elucidate the underlying molecular mechanisms of the observed synergistic effects of PIs, we focused on the tran...

Ngày tải lên: 18/02/2014, 17:20

... decapeptides overlapping the amino acid sequence of mature cathep- sin B (Fig. S1) were synthesized on the spots of cellu- lose membrane. After incubation of the membrane with 2A2 mAb, followed by the detection ... the presence of various concentrations of 2A2 mAb. The binding of 2A2 mAb was followed by native gel elec- trophoresis. Increasing the concentration of 2A2 mAb...

Ngày tải lên: 18/02/2014, 11:20

... with a stochiometry of 1 : 1 of dTTP bound per subunit of dCTP deaminase. Mutational analysis of amino acid residues involved in dTTP regulation of dCTP deaminase The design of the mutant enzymes ... analyse the roles of His121 and Val122 in catalysis and regulation of dCTP deaminase. Removal of the imidazole ring in H121A was anticipa- ted to relieve or reduce inhibit...

Ngày tải lên: 18/02/2014, 16:20

... Inhibition of the ATPase activity was then explained by a slowing down of the formation of active complex in solution. On the other hand, the acceleration of the sliding velocity (and the lower number of ... properties of an additional natural component of the thin filament framework, nebulin. Nebulin spans the entire length of thin filaments and is capable of modulating the...

Ngày tải lên: 19/02/2014, 16:20

... in the regulation of apop- tosis [21,22]. Thus, the possibility that the antiviral effect of spermine is mediated by induction of apop- tosis was analyzed. For this purpose, the effect of spermine ... view of regulation of gene expression by double-stranded RNA-mediated cell sig- naling. J Biol Chem 30, 30. 35 Shah N, Thomas T, Shirahata A, Sigal LH & Thomas TJ (1999)...

Ngày tải lên: 07/03/2014, 21:20

... understanding of the regulation of calpain B. According to homolo- gous modeling, the amino acid residues phosphory- lated by PKA and the ERK isoforms are situated in sensitive regions of the molecule ... low stoichiometry of phosphorylation in the case of PKA, and by the existence of multiple phosphorylation sites in all cases. To assess the contribution of a well estab...

Ngày tải lên: 16/03/2014, 02:20

... chains of Glu193 and Ser146 help to stabilize the transition state of the c-phosphate group of ATP by magnesium ion. Lys13 is also found to be within 3–4 A ˚ of the C5 hydroxyl group of mevalonic acid. ... studies have shown that binding of MVK to LHR mRNA suppresses the translation of mRNA in vitro [14]. As the mutation of any of the four amino acids at the active site...

Ngày tải lên: 16/03/2014, 06:20

... total amount of mRNA but also by the propor- tions of the different 5¢-UTRs within these messages, allowing the fine tuning of DLG1 expression according to the physiological requirements of the cell. Materials ... analysis The statistical significance of the data from the luciferase assays was obtained by analysis of variance (ANOVA), fol- lowed by multiple comparisons perform...

Ngày tải lên: 22/03/2014, 16:20