Báo cáo khoa học: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression pot

... units) * * ¶ CREB PKA BetA +++ ++– +–– CTL BetA siCREBBetA/CREB CTL BetA siCREBBetA/CREB CTL BetA siCREB BetA/CREB CTL BetA siCREBBetA/CREB CTL BetA siCREBBetA/CREB Fig. 4. BetA-mediated SOD2 suppression ... inhibitory < /b> effects on < /b> hepatitis < /b> B virus (HBV). In hepatocytes from HBV-transgenic mice, we showed that BetA substantially inhibited HBV replication by downreg...

Ngày tải lên: 16/03/2014, 01:20

Ngày tải lên: 16/02/2014, 15:20

... function by affect- ing the conformation of the b- domain. Based upon the molecular structure of GIF, we have conducted a systematic mutational study on < /b> the struc- ture–property–reactivity–function ... the first segment demonstrated to be indispensible for the neuronal growth -inhibitory < /b> activity of GIF [6,17]. The bioactivity of GIF is com- pletely abolished by a do...

Ngày tải lên: 16/02/2014, 15:20

... isomeriza- tion of the Cys-Pro amide bonds in the Cys 6 -Pro-Cys- Pro(6–9) motif [17]. Only one configuration is detected by 113 Cd(II)-NMR, whereas the other is broadened beyond detection by fast ... oxidatively unstable under aerobic conditions as a result of the formation of disulfide bridges [2]. Sec- ond, in contrast to the high thermodynamic stability, the binding is kinetically...

Ngày tải lên: 16/02/2014, 15:20

... this regard, GIF has been demonstrated to not only prevent Ab aggregation, but also block the generation of ROS by Ab-Cu(II) [27,38]. Therefore, the ability of GIF to redox-silence metal ions and directly ... 2010) doi:10.1111/j.1742-4658.2010.07718.x Neuronal growth -inhibitory < /b> factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein f...

Ngày tải lên: 16/02/2014, 15:20

... and substrate specificity of the enzyme. XAN By contrast to results on < /b> XBS, the activity on < /b> X 6 is affected by a number of the mutations made in the SBS of XAN. A much lower activity is observed ... volume of 7.80 mL after 10 min of pre-incubation. During incubation, the sam- ples were continuously stirred. For OSX, the reaction was terminated by the addition of...

Ngày tải lên: 14/02/2014, 19:20

... transcriptional regulation network of dmrt1 and cyp19a1 in gonadal development. Expression, regulation and functions of dmrt1a/dmrt 1bY in medaka In the medaka, which has XY–XX sex determination, dmrt 1bY, ... autoregulation of dmrt 1bY promoter activity and transregulation by its paralogue Dmrt1a is a key mechanism of dmrt 1bY transcriptional tuning. Post-transcrip- tional regu...

Ngày tải lên: 14/02/2014, 19:20

... use of F-actin-rich membrane projections may be related to surfing on < /b> filopodia (Fig. 1) that might be conserved among unrelated viruses [28]. Expression of nectin-1 on < /b> filopodia has been demonstrated, ... based on < /b> quantitation of b- galacto- sidase expressed from the viral genome or by CHO-IEb8 cells in which b- galactosidase expression is inducible by herpe...

Ngày tải lên: 18/02/2014, 14:20

... not contain any divalent cations, the magnesium ion is probably co-purified with the pro- tein. The ion is coordinated by the carboxyl oxygen atoms of D8, D9, by the carboxamide oxygen of N92, by ... that of the monoclinic form. The total surface-accessible area buried on < /b> dimerization of A and B subunits of the monoclinic form is 7633 A ˚ 2 , which suggests tight assoc...

Ngày tải lên: 18/02/2014, 14:20

... compilation ª 2009 FEBS 7389 stimulated with LPS (Fig. 4A ,B) . Inhibition of MCPIP gene expression by siRNA (by approximately 40%) led to an increase in the endogenous IL- 1b transcript level (by approximately ... transcripts of both IL- 1b and MCPIP observed in an RNA immunoprecipitation assay suggests that this novel RNase may be involved in the regulation of expression o...

Ngày tải lên: 18/02/2014, 14:20