Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot

... MINIREVIEW A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer Scott A. Waldman1 and Andre Terzic21 Departments of Pharmacology and Experimental Therapeutics ... Missiaglia E, Hagan JP, Falconi M, CapelliP, Bersani S, Calin GA, Volinia S, Liu CG, Scarpa A et al. (2006) MicroRNA expression abnormalities in Applications in cancer for microRNAs S. A. Waldman ... tissues in various cancer types, including CLL, breast cancer, glioblastoma, thyroid papillary carcinoma, hepatocel-lular carcinoma, lung cancer, colon cancer and endo-crine pancreatic tumors...

Báo cáo khoa học: A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation doc

... regu-latory networks during developmental stages and thechanges of these networks in disease and after applica-tion of a variety of therapeutic strategies. Critically,the noninvasive imaging approach ... miRNA in vivo as wellas for monitoring the therapeutic potential of miRNAs in cancer. Bioimaging of microRNA biogenesisThe molecular mechanisms involved in miRNA gener-ation are complex, and at ... the realaction of mature miRNA in mammalian cells, com-pared with reporter-imaging systems that use perfecttarget sequences from miRNAs. In vivo imaging of miRNA in cancers and neuronal developmentmiRNAs...

Tài liệu Báo cáo khoa học: "A study of Information Retrieval weighting schemes for sentiment analysis" doc

... effectiveness than any individualclassiﬁer, especially when sufﬁcient training dataisn’t available. In contrast to machine learning approachesthat require labeled corpora for training, Lin and 1387He ... 2005), Vancouver, CA.Ian H. Witten and Eibe Frank. 1999. Data Mining:Practical Machine Learning Tools and Techniqueswith Java Implementations (The Morgan KaufmannSeries in Data Management ... Additionally, the data set is par-ticularly large compared to the other ones, makingclassiﬁcation especially challenging and interest-ing. More information about all data sets can befound at table...

Báo cáo khoa học: A study on genomic distribution and sequence features of human long inverted repeats reveals species-speciﬁc intronic inverted repeats pptx

... sites, as shown in a recent study in which evidence obtained in vivo demonstrated repli-cation stalling by hairpins formed by inverted repeats in bacteria, yeast and mammalian cells [11]. As a result, ... initiation of DNA replication in plas-mids, bacteria, eukaryotic viruses and mammalian cells[24]. The inverted repeats in introns are able to affectthe alternative splicing of exons [25,26] and theremoval ... exclude an abundance of inverted repeats formedby (TA)nsimple repeats as shown in our primary study. A (TA)nby itself is an inverted repeat, and can form variantsecondary structures rather than...

Tài liệu Báo cáo khoa học: A role of miR-27 in the regulation of adipogenesis ppt

... control was maintained in a standard incubator with 21% O2. The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... epididymal fat pads harvested from ob ⁄ obmice and genetically matched lean mice. Levels of miRNA expres-sion were analyzed by TaqMan quantitative PCR. Data are meanvalue ± standard errors of the ... determined in 3T3-L1cells at the protein level using western blot analysis onday 1 and day 4 of differentiation, a time frame forobservation of early genes and induction of C ⁄ EBPa and PPARc....

Tài liệu Báo cáo khoa học: "A Comparison of Alternative Parse Tree Paths for Labeling Semantic Roles" ppt

... Minipar B: A second parse tree path encoding was generated from Minipar parses that relaxes some of the constraints used in Minpar A. In- stead of using all the information contained at a ... paper. 3 Aligning arguments to parse trees nodes in a training / testing corpus We began our investigation by creating a training and testing corpus of 400 sentences each contain-ing an inflection ... performance of Minipar A would continue to improve with the addition of more training data, suggesting that this approach might be well-suited for applications where lots of training data is available....

Tài liệu Báo cáo khoa học: "A SNAPSHOT OF KDS A KNOWLEDGE" pot

... coordination of communication with non-linguistic activities by • gcel-pursuin~ planner, end the use of dynamic models of speaker and hearer to shape the text to the task at hand. STATEMENT ... details, see Mann and Moore [ 1979]. However, to communicate the flavor of what ~ve have accomplished from the motivating goal: (WANTS SPEAKER (KNOWS HEARER F ldlE-ALARM-SCENE)) and about ... sub-activities: AGGREGATOR applies rules to combine two or three fragments into a single one. A typical aggregation rule is: "The two fragments 'x does A& apos; and 'x does B' can be...

Tài liệu Báo cáo khoa học: "A GENERALIZATION OF THE OFFLINE PARSABLE GRAMMARS" doc

... A GENERALIZATION OF THE OFFLINE PARSABLE GRAMMARS Andrew Haas BBN Systems and Technologies, 10 Moulton St., Cambridge MA. 02138 ABSTRACT The offline parsable grammars apparently have ... (A& apos;,B) ~ D t, and s is the most general unifier of A n and A& apos; (after suitable renaming of variables). Then the set of ground instances of lists in D n is the set of chain derivations ... conjectures that grammars whose acyclic backbone is depth-bounded in fact generate the same languages as the offline parsable grammars. Conclusion The offline parsable grammars apparently have enough...

Báo cáo khoa học: NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B–NS3 protease ppt

... occurs in Africa, Europe and Asia and, since 1999, has also been spreading in NorthAmerica, causing several thousand cases per year, with a fatality rate of 5%, as reported by the US Depart-ment ... activity and with inhibitors that targetthe substrate-binding site. Indeed, the G15 1A mutantwas inactive in the enzymatic assay [25] and unable tobind 3 (Fig. S6).Having established that compound ... Subhash G. Vasudevan2,* and Gottfried Otting11 Research School of Chemistry, Australian National University, Canberra, Australia2 Novartis Institute for Tropical Diseases, Singapore3 Department...

Báo cáo khoa học: "A Study on Automatically Extracted Keywords in Text Categorization" doc

... IntroductionAutomatic text categorization is the task of assign-ing any of a set of predeﬁned categories to a doc-ument. The prevailing approach is that of super-vised machine learning, in which an algorithm ... re-call, and 81.0% F-measure. When the intact key-words are used as feature input with a boolean fea-ture value and at least three occurrences in train-ing data, the performance decreases greatly ... profes-sional indexers are used as a gold standard, thatis, the manual keywords are treated as the one and only truth. The evaluation measures are preci-sion (how many of the automatically assigned...

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