Báo cáo khoa học: A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer pot

... MINIREVIEW A study of microRNAs in silico and in vivo: diagnostic and therapeutic applications in cancer Scott A. Waldman 1 and Andre Terzic 2 1 Departments of Pharmacology and Experimental Therapeutics ... Missiaglia E, Hagan JP, Falconi M, Capelli P, Bersani S, Calin GA, Volinia S, Liu CG, Scarpa A et al. (2006) MicroRNA expression abnormalities in...

Ngày tải lên: 16/03/2014, 01:20

... regu- latory networks during developmental stages and the changes of these networks in disease and after applica- tion of a variety of therapeutic strategies. Critically, the noninvasive imaging approach ... miRNA in vivo as well as for monitoring the therapeutic potential of miRNAs in cancer. Bioimaging of microRNA biogenesis The molecular mechanisms involved in...

Ngày tải lên: 16/03/2014, 01:20

... effectiveness than any individual classifier, especially when sufficient training data isn’t available. In contrast to machine learning approaches that require labeled corpora for training, Lin and 1387 He ... 2005), Vancouver, CA. Ian H. Witten and Eibe Frank. 1999. Data Mining: Practical Machine Learning Tools and Techniques with Java Implementations (The Morgan Kaufmann Series in D...

Ngày tải lên: 20/02/2014, 04:20

... sites, as shown in a recent study in which evidence obtained in vivo demonstrated repli- cation stalling by hairpins formed by inverted repeats in bacteria, yeast and mammalian cells [11]. As a result, ... initiation of DNA replication in plas- mids, bacteria, eukaryotic viruses and mammalian cells [24]. The inverted repeats in introns are able to affect the alternativ...

Ngày tải lên: 07/03/2014, 00:20

... control was maintained in a standard incubator with 21% O 2 . The normoxia data are the same as shown in Fig. 1 and are included here for comparison. Expression of miR-2 7a and miR-27b at the indicated ... epididymal fat pads harvested from ob ⁄ ob mice and genetically matched lean mice. Levels of miRNA expres- sion were analyzed by TaqMan quantitative PCR. Data are mean valu...

Ngày tải lên: 18/02/2014, 08:20

... Minipar B: A second parse tree path encoding was generated from Minipar parses that relaxes some of the constraints used in Minpar A. In- stead of using all the information contained at a ... paper. 3 Aligning arguments to parse trees nodes in a training / testing corpus We began our investigation by creating a training and testing corpus of 400 sentences each con...

Ngày tải lên: 20/02/2014, 12:20

... coordination of communication with non-linguistic activities by • gcel-pursuin~ planner, end the use of dynamic models of speaker and hearer to shape the text to the task at hand. STATEMENT ... details, see Mann and Moore [ 1979]. However, to communicate the flavor of what ~ve have accomplished from the motivating goal: (WANTS SPEAKER (KNOWS HEARER F ldlE-ALARM-SCENE))...

Ngày tải lên: 21/02/2014, 20:20

... A GENERALIZATION OF THE OFFLINE PARSABLE GRAMMARS Andrew Haas BBN Systems and Technologies, 10 Moulton St., Cambridge MA. 02138 ABSTRACT The offline parsable grammars apparently have ... (A& apos;,B) ~ D t, and s is the most general unifier of A n and A& apos; (after suitable renaming of variables). Then the set of ground instances of lists in D n is the set o...

Ngày tải lên: 21/02/2014, 20:20

... occurs in Africa, Europe and Asia and, since 1999, has also been spreading in North America, causing several thousand cases per year, with a fatality rate of 5%, as reported by the US Depart- ment ... activity and with inhibitors that target the substrate-binding site. Indeed, the G15 1A mutant was inactive in the enzymatic assay [25] and unable to bind 3 (Fig. S6). Having...

Ngày tải lên: 07/03/2014, 02:20

... Introduction Automatic text categorization is the task of assign- ing any of a set of predefined categories to a doc- ument. The prevailing approach is that of super- vised machine learning, in which an algorithm ... re- call, and 81.0% F-measure. When the intact key- words are used as feature input with a boolean fea- ture value and at least three occurrences in train- i...

Ngày tải lên: 08/03/2014, 02:21