Báo cáo khoa học: Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B docx

... Zarse 2 , Martin Steinhoff 1 and Wolfgang Meyerhof 2 1 Department of Dermatology, IZKF Mu ¨ nster and Ludwig Boltzmann Institute for Cell and Immunobiology of the Skin, Germany 2 Department of Molecular ... stimulation of SSTR1 induced accumulation of SST-14 in cells via a dynamic process of internalization, recycling and rein- ternalization of the ligand [11]. In contrast, stim...

Ngày tải lên: 16/03/2014, 06:20

... & Antonini E (1968) The binding of carbon monoxide by human hemoglobin. Proof of valid- ity of the spectrophotometric method and direct determi- nation of the equilibrium. J Biol Chem, 243, ... University of Roma ‘Tor Vergata’, Italy 4 Department of Molecular, Cellular and Animal Biology, University of Camerino, Italy 5 Department of Structural and Functional Biology, and...

Ngày tải lên: 16/02/2014, 14:20

... supported by National Technology Agency of Finland and Ministry of Education of Finland (to J. I. V.). We wish to thank Prof. Dan Larhammar, University of Uppsala, for his advice and extremely ... respect to the studied enzymes of the POP family, POP seems to be the most conserved enzyme. Ten conserved amino acids were found at the active site of the enzyme of each of the stud...

Ngày tải lên: 19/02/2014, 13:20

... unfortunately is difficult to measure objectively 114 Figure 2: Screenshot of Part 1a of the Experiment Figure 3: Screenshot of Part 1b of the Experiment Total Average Rank 1 Rank 2 Rank 3 Rank Original ... 70% of the time, the judges chose between only 2 of them. For the items with 5 possible alternatives, in 10% of those items the human judges chose only 1 of those al- tern...

Ngày tải lên: 22/02/2014, 02:20

... a circle of radius 14 A ˚ or a square with sides of 25 A ˚ . The significance of this value will be discussed below. SWwasalsousedtofollowDgAOR redox behavior from a drop of solution of the enzyme ... to the adsorption of the oxidized (O) and reduced (R) species, respectively. So, the location of E p with respect to E  ¢ depends on the relative strength of adsorption of th...

Ngày tải lên: 07/03/2014, 15:20

... 18 transcripts with a total of 11,704 words and a mean length of utterance of 2.9, and (B) 23 transcripts with a total of 40,819 words and a mean length of utterance of 7.0. 5.2 Results Scores ... several areas of human lan- guage technologies. Similarly, in the study of child language, the availability of large amounts of elec- tronically accessible empirical data in the...

Ngày tải lên: 08/03/2014, 04:22

... [15]). In the case of the IL-4 antagonist variant Y124D the formation of the ternary complex is blocked (D). Circles mark the interaction of the tyrosine residue of IL-4 with residues of cc. (E) Closer ... memories of the opening ceremony in the opera house, which was initiated by the fanfare of Janacek’s Sinfonietta. This is one of the reasons why when I think of Prague I a...

Ngày tải lên: 15/03/2014, 09:20

... (2006) Valosin- containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells. ... substitution of these two arginines. We map the site of binding of Ube4b to the N-domain of VCP and show that it competes for this site with Hrd1. Finally, we investigate the e...

Ngày tải lên: 18/02/2014, 13:20

... preventing the generation of potentially harmful semiquinones. In recent years, an additional role of quinone reductases as regulators of proteaso- mal degradation of transcription factors and ... recognition of p53 involves post-translational modifications. Accumulation of p53 then results in the expression of a variety of genes necessary to cope with DNA damage and other fo...

Ngày tải lên: 16/03/2014, 02:20

... The occurrence of and properties of two different types of photoinactivation. Plant Cell Physiol 11, 29–38. 9 Satoh K & Fork DC (1982) Photoinhibition of reaction centers of photosystem I ... Kamo M, Hihara T & Enami I (1997) The mechanism of the degradation of PsaB gene product, one of the photosynthetic reaction center subunits of photosystem I, upon photoinhibit...

Ngày tải lên: 16/03/2014, 18:20