... cannot bindproMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting itsactivity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2 ... chemokine-mediatedrecruitment of leukocytes into sites of in ammation[76]. Many chemokines bind HS chains of syndecans and evoke MMP-mediated shedding of syndecans withpotential loss from the site of injury [40,41,56]. ... 2010 FEBS 3889MINIREVIEW Proteoglycans in health and disease: the multiple roles of syndecan shedding Tina Manon-Jensen1, Yoshifumi Itoh2 and John R. Couchman11 Deparment of Biomedical Sciences,...