Báo cáo khoa học: Proteoglycans in health and disease: the multiple roles of syndecan shedding ppt

... cannot bind proMMP2, but the N-terminal region of TIMP-2 binds the catalytic domain of MT1-MMP inhibiting its activity, whereas its C-terminal domain binds to the hemopexin-like domain of Pro-MMP-2 ... chemokine-mediated recruitment of leukocytes into sites of in ammation [76]. Many chemokines bind HS chains of syndecans and evoke MMP-mediated shedding of syndecans wi...

Ngày tải lên: 15/03/2014, 23:20

... over- lapping with the EGF-binding domain [32]. The structural constraints of the EGFR binding region support a stochiometry of 1 : 1 for the decorin pro- tein core and EGFR, suggesting that decorin ... 3867 decorin in the regulation of IGF-IR and to clarify whether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin...

Ngày tải lên: 15/03/2014, 23:20

... remodeling of the extracellular matrix, thereby facilitating cell invasion. Progress in the field has expanded the scope of heparanase function and its significance in tumor progression and other pathologies. ... remodeling of the ECM under- lying tumor and endothelial cells, thereby facilitating cell invasion [23–25]. Progress in the field and the gen- eration o...

Ngày tải lên: 15/03/2014, 23:20

... originating from different precursor molecules, while thick lines indicate the intact carbon connectivities in the fragments arising from a single precursor molecule. The carbon skeletons of the intermediates ... However, the 13 C-labeling pattern arising from the action of the glyoxylate cycle and the efflux of oxaloacetate (OAA) from the mitochondria cannot be dist...

Ngày tải lên: 23/03/2014, 12:20

... compo- nent accounting for the main part of the user in- teraction and a mobile component which follows the users in actual exercise activities. Section 2 outlines the overall system and its two basic ... to themobile part and in return gets the results of the performed ex- ercises from the mobile component. 65 Figure 2: Home Companion interface 2.1 The Home H&...

Ngày tải lên: 22/02/2014, 02:20

... works containing interleukin receptor-associated kinase family. Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as critical mitogen-activated protein kinase kinase kinase ... but in concert with a number of conserved domains, including a GTPase domain. Multidomain proteins that encode functional kinase domains often utilize intrinsic protein ki...

Ngày tải lên: 23/03/2014, 04:20

... proteins in slime mold D. discoideum The finding of the conserved ROC and COR domains in LRRK2 has stirred particular interest with respect to studying the functions of the known ROCO pro- teins. The ... mechanism of cytokinesis impairment. Taken together, the studies of mutant phe- notypes for the two ROCO proteins in D. discoideum indicate their roles in reg...

Ngày tải lên: 23/03/2014, 04:20

... progressive and profound loss of neuromelanin-containing dopaminer- gic neurons in the substantia nigra pars compacta with the presence of eosinophillic, intracytoplasmic and pro- teinaceous inclusions ... kinase and WD40 domains. The presence of the four protein–protein interaction domains (ARM, ANK, LRR and WD40) strongly suggests a role of LRRK2 in protein compl...

Ngày tải lên: 23/03/2014, 04:20

... between parsing and generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing is top-down ... method of generation are that of the 'pivot', and that of partitioning the grammar intO 'chaining' and 'noD-chaining ' rules. Loosel...

Ngày tải lên: 24/03/2014, 02:20

... pre- dicting case from the in ection prediction step to the stem translation step. Since the choice of case in a PP is often determined by the PP’s meaning (and there are often different meanings ... combining the strengths of both of these approaches. We address the problem of word-formation for compounds in German, by translating from English into German word part...

Ngày tải lên: 24/03/2014, 03:20