Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt

... 3867 decorin in the regulation of IGF-IR and to clarify whether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin signaling is further expanded by additional ... as enhancing its binding to chordin [71]. The latter, in turn, leads to BMP-4 inactivation by the chordin– twisted gastrulation complex [71]. Lumican signalin...

Ngày tải lên: 15/03/2014, 23:20

... generated by the home system during a session with the user. If the user chooses to download the plan the Companion summarizes the content of the plan for the user, excluding all tasks that do not involve ... from the device’s file system and evalu- ated in a script interpreter created by the midlet when started. The scripts have access to a num- ber of commands,...

Ngày tải lên: 22/02/2014, 02:20

... of the C-terminal domain was lacking. These results indicate that the interaction between MMP-9 and the CSPG core protein must involve the most C-terminal part of the MMP-9 hemopexin-like domain. ... followed by a stepwise shortening of the C-terminal domain. It appeared that the core protein of the CSPG was cleaved prior to the processing and shortening of the C-ter...

Ngày tải lên: 17/03/2014, 10:20

... G2019S localized to the activation loop and Mg 2+ binding site of the kinase domain [5]. Missense mutations occurring in analogous regions in the b-RAF protein kinase (e.g. the kinase activation ... works containing interleukin receptor-associated kinase family. Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as critical mitogen-activated...

Ngày tải lên: 23/03/2014, 04:20

... showed that the kinase domain alone is insufficient to complement the chemotactic defect in the GbpC-deletion mutant. Furthermore, the study indicated that the LRR, ROC and kinase domains are all ... process of searching binding proteins, the in vivo evidence for the relation- ship between ROCO proteins and cytoskeletons in D. discoideum suggests a need to further inves...

Ngày tải lên: 23/03/2014, 04:20

... clini- cally by resting tremor, rigidity, bradykinesia and postural instability. This condition was first described in 1817 by James Parkinson in his seminal paper the shaking palsy’. Although PD predominantly ... alters the net positive charge of the WD40 domain. Because WD40 domain is involved in mediat- ing protein–protein interactions, the LRRK2 G2385R variant may impact...

Ngày tải lên: 23/03/2014, 04:20

... between parsing and generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing is top-down ... as the head unifies with that of the left- hand side category. Other rules are non-chaining roles. Rules that apply between the root and the pivot are, by definition,...

Ngày tải lên: 24/03/2014, 02:20

... tags in the input. Verbs are in ected in the input (“haben”, meaning “have” as in “they have”, in the example). Prepositions are lexicalized (“zu” in the example) and indicate which case value they ... different training data sizes of the single and the four separate joint sequence models. As we mentioned in Section 4, there is a spar- sity issue at small traini...

Ngày tải lên: 24/03/2014, 03:20

... erucalexin, rutalexin, brassilexin, cyclobrassinin and camalexin (0.10 and 0.30 mm final concentrations). The phyto- alexin that displayed an inhibitory effect was further examined in order to determine the ... type of inhibition and the K i using brassinin (0.10–0.40 mm) as a sub- strate in the presence of inhibitor (0.10, 0.20 and 0.40 mm). The kinetics of inhibition wa...

Ngày tải lên: 18/02/2014, 14:20

... screening for small binding proteins. The preparation of the small binding proteins with binding function further allows us to increase the binding strength by multi- binding approaches, constructing ... the candidate location in NCS for grafting with the CDR 3 loop of VHH. (B) Insertion of the CDR 1-containing loop of the heavy chain in Fv into the candidate locatio...

Ngày tải lên: 06/03/2014, 11:20