Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
Báo cáo khoa học: Proteoglycans in health and disease: novel regulatory signaling mechanisms evoked by the small leucine-rich proteoglycans ppt
... 3867decorin in the regulation of IGF-IR and to clarifywhether decorin ⁄ IGF-IR signaling might be operative in carcinoma cells as well. The complexity of decorin signaling is furtherexpanded by additional ... asenhancing its binding to chordin [71]. The latter, in turn, leads to BMP-4 inactivation by the chordin–twisted gastrulation complex [71].Lumican signaling in cell growth and in ammation The role ... com-plex are modulated by lumican -evoked signaling, including vinculin and focal adhesion kinase [82].Lumican alters the relationship between actin filaments and b1 integrin, which in turn would affect...
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Tài liệu Báo cáo khoa học: "A Mobile Health and Fitness Companion Demonstrator" pptx
... generated by the home systemduring a session with the user. If the user choosesto download the plan the Companion summarizes the content of the plan for the user, excluding alltasks that do not involve ... from the device’s file system and evalu-ated in a script interpreter created by the midletwhen started. The scripts have access to a num-ber of commands, allowing them to initiate TTS and ASR ... compo-nent accounting for the main part of the user in- teraction and a mobile component which follows the users in actual exercise activities. Section 2outlines the overall system and its two basic...
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Báo cáo khoa học: Calcium-induced activation and truncation of promatrix metalloproteinase-9 linked to the core protein of chondroitin sulfate proteoglycans pot
... of the C-terminal domainwas lacking. These results indicate that the interactionbetween MMP-9 and the CSPG core protein must involve the most C-terminal part of the MMP-9 hemopexin-likedomain. ... followed by a stepwise shortening of the C-terminal domain. It appeared that the core protein of the CSPG was cleaved prior to the processing and shortening of the C-terminal hemopexin-like domain, ... expected, the degradation and removal of CS-chainsfrom the complex resulted in the disappearance or a largereduction of the bands in the stacking gel and the band at300 kDa, and new bands around...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: function in cells and neurodegeneration doc
... G2019S localized to the activation loop and Mg2+binding site of the kinasedomain [5]. Missense mutations occurring in analogousregions in the b-RAF protein kinase (e.g. the kinaseactivation ... workscontaining interleukin receptor-associated kinasefamily. Many of these kinases have clear roles in the MAPK pathway, and MLK proteins serve as criticalmitogen-activated protein kinase kinase kinase ... but in concert with anumber of conserved domains, including a GTPasedomain. Multidomain proteins that encode functionalkinase domains often utilize intrinsic protein kinaseactivity distinct...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: in vivo models and approaches for understanding pathogenic roles pdf
... showed that the kinase domain alone isinsufficient to complement the chemotactic defect in the GbpC-deletion mutant. Furthermore, the studyindicated that the LRR, ROC and kinase domains areall ... process of searchingbinding proteins, the in vivo evidence for the relation-ship between ROCO proteins and cytoskeletons in D. discoideum suggests a need to further investigate the possibility ... apparatus,controls the directionality of synaptic vesicle proteins by restricting these proteins from going to the dendrites. This result further indicates a critical func-tion of LRK-1 in establishing the...
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Báo cáo khoa học: LRRK2 in Parkinson’s disease: genetic and clinical studies from patients ppt
... clini-cally by resting tremor, rigidity, bradykinesia and postural instability. This condition was first described in 1817 by James Parkinson in his seminal paper the shaking palsy’. Although PD predominantly ... alters the net positive charge of the WD40domain. Because WD40 domain is involved in mediat-ing protein–protein interactions, the LRRK2 G2385Rvariant may impact on interactions with substrates and ... fromEuropean and US origin and for 1–3% of sporadicPD from most Caucasian populations. This mutationis located in the kinase domain of the protein and maybe associated with increased kinase activity...
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Báo cáo khoa học: "Asymmetry in Parsing and Generating with Unification Grammars: Case Studies From ELU" pot
... between parsing and generating lies in the nature of the input. The text, as a string of words, traditionally establishes the starting point of parsing; whether the processing is top-down ... as the head unifies with that of the left- hand side category. Other rules are non-chaining roles. Rules that apply between the root and the pivot are, by definition, chaining rules; further, ... b. Fmd a non-chaining rule which can have the pivot as mother, similarly making sure that the FS resulting from the unification of the pivot and the mother can be linked up to the current FS....
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Báo cáo khoa học: "Modeling Inflection and Word-Formation in SMT" doc
... tags in the input. Verbs are in ected in the input (“haben”, meaning“have” as in “they have”, in the example). Prepositions are lexicalized (“zu” in the example) and indicate whichcase value they ... different training data sizes of the single and the four separate joint sequence models.As we mentioned in Section 4, there is a spar-sity issue at small training data sizes for the sin-gle joint sequence ... pre-dicting case from the in ection prediction step to the stem translation step. Since the choice of case in a PP is often determined by the PP’s meaning (and there are often different meanings...
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Tài liệu Báo cáo khoa học: Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola ppt
... erucalexin,rutalexin, brassilexin, cyclobrassinin and camalexin(0.10 and 0.30 mm final concentrations). The phyto-alexin that displayed an inhibitory effect was furtherexamined in order to determine the ... type of inhibition and the Kiusing brassinin (0.10–0.40 mm) as a sub-strate in the presence of inhibitor (0.10, 0.20 and 0.40 mm). The kinetics of inhibition was transformedinto Lineweaver–Burk ... by 3-phenylindole and camalexin. BO was isolated from the wild-type fungus and found to be competitively inhibited by the crucif-erous phytoalexins cyclobrassinin and camalexin.Furthermore,...
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Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... screeningfor small binding proteins. The preparation of the small binding proteins with binding function furtherallows us to increase the binding strength by multi-binding approaches, constructing ... the candidate location in NCS for grafting with the CDR 3 loop of VHH. (B) Insertion of the CDR 1-containing loop of the heavy chain in Fv into the candidate location in TOP.Generation of binding ... to increase the density of libraries.This minireview series describes the methodology forelucidating protein–protein interactions and selectingspecific binders to novel target proteins, and the...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhối hợp giữa phòng văn hóa và thông tin với phòng giáo dục và đào tạo trong việc tuyên truyền, giáo dục, vận động xây dựng nông thôn mới huyện thanh thủy, tỉnh phú thọPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Thiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Kiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)Tăng trưởng tín dụng hộ sản xuất nông nghiệp tại Ngân hàng Nông nghiệp và Phát triển nông thôn Việt Nam chi nhánh tỉnh Bắc Giang (Luận văn thạc sĩ)Nguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIMÔN TRUYỀN THÔNG MARKETING TÍCH HỢP