Báo cáo khoa học: 3¢- to 5¢ DNA unwinding by TIP49b proteins docx

... failed to unwind synthetic blunt-ended duplex DNA (Fig. 5H) suggesting that PDH120 requires ssDNA adjacent to the duplex as a loading zone. Direction of DNA unwinding by PDH120 The strand to which ... [1]. The ssDNA template is provided by a group of enzymes called DNA helicases, which catalyse the DNA unwinding in an ATP-dependent manner and thereby act as an essential...

Ngày tải lên: 20/02/2014, 11:20

... elastic fibers. Furthermore, the elastomeric properties have been related to the capacity to shift from a weakly globular structure to an extended form, mediated by the Pro- and Gly-rich repeats ... short pre- dicted secondary structures tend to move along the pri- mary structure (Fig. S1), whereas a helices tend to stretch or to bend. This was confirmed by two longer lasting si...

Ngày tải lên: 14/02/2014, 18:20

... 689 prodeath proteins to the mitochondria, causing cyto- chrome c release and caspase-3 activation [34,35]. In troglitazone-treated apoptotic adipocytes, the translo- cation of Bax from the cytoplasm into ... troglitazone induces apopto- sis in prostate cancer cells by directly binding to Bcl-2 and Bcl-xL [40]. Owing to its inability to bind to Bcl-2 and Bcl-xL, pioglitazone can...

Ngày tải lên: 16/02/2014, 09:20

... be given by the proteins separated from plasma by proteomic devices, we now have to add all these data to the genomic and transcriptomic ones. Biological systems are then the only way to put all ... procedure to identify different types of ATP-binding to proteins in a total cellular con- text. S4.1-3 Learning from evolution to predict protein structure and function A. Tram...

Ngày tải lên: 19/02/2014, 07:20

... between the 5¢ extremity of an RNA with its 3¢ end was proposed to explain why 5¢ monophosphorylated RNAs are more efficently adeny- lated by PAP I than those harboring a triphosphoryl- ated 5¢ end ... downstream of the terminator. The PCR frag- ment digested by NdeI and BamHI was inserted into pUC18 vector that had been digested with the same enzymes. The Hfq containing DNA frag...

Ngày tải lên: 19/02/2014, 16:20

... parame- terized by weight vector w, takes in a foreign sen- tence f and returns a translated hypothesis h. The argmax operates in vector space and our goal is to find w leading to hypotheses on the Pareto ... attention to some limitations and opportunities raised by this work: Limitations: (1) The performance of PMO is limited by the size of the Pareto set. Small N-best lists lead...

Ngày tải lên: 19/02/2014, 19:20

... source term and partial translation to a search engine is a good strategy used by many translators. Unfortunately, the user still has to sift through snippets to find the translations. For a given ... Thus, we also associate features to each Chinese token (characters or words) to reflect the likelihood of the token being part of the translation. We describe how to train...

Ngày tải lên: 19/02/2014, 19:20

... organized by spatial word. The top row shows the weights of allocentric (landmark-centered) features. For example, the top left figure shows that when the word above occurs, our policy prefers to go to ... Re- search Fellowship to the first author and award IIS-0811974 to the second author and by the Air Force Research Laboratory (AFRL), under prime contract no. FA8750-09-C-0181. Th...

Ngày tải lên: 20/02/2014, 04:20

... 2.5 Tokenizer Tokenizers (also known as lexical analyzers or word segmenters) segment a stream of characters into meaningful units called tokens. The tokenizer takes the text generated by ... Machine Translation system. It takes token generated by the tokenizer as input and outputs the translated token in the target language. These translated tokens are concatenated one after ano...

Ngày tải lên: 20/02/2014, 05:20

Ngày tải lên: 20/02/2014, 09:20