Báo cáo khoa học: Protein tandem repeats – the more perfect, the less structured pptx
Báo cáo khoa học: Protein tandem repeats – the more perfect, the less structured pptx
... Jorda et al.
2682 FEBS Journal 277 (2010) 267 3–2 682 ª 2010 The Authors Journal compilation ª 2010 FEBS
Protein tandem repeats – the more perfect, the less
structured
Julien Jorda
1
, Bin Xue
2,3
, ... and homorepeats
with P
sim
= 1.0 (5259 TRs). Homorepeats were analy-
sed separately from the other TRs, because they signif-
icantly outnumber the other types of...
Báo cáo khoa học: Protein folding includes oligomerization – examples from the endoplasmic reticulum and cytosol doc
... proteins from
the Golgi apparatus to the ER [159,160].
For a newly synthesized protein to exit the ER or,
in other words, to pass the ER quality control, two
conditions need to be met: (a) the protein ... to
whether the fine structure of such a protein is truly
identical in all cells, or whether the routes to the final
structure are similar.
A nascent protein emerging fr...
Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... have therefore elucidated
the first building blocks of the putative ‘olfactosome’, brought together
by the scaffolding protein MUPP1, a possible central nucleator of the
olfactory response.
Structured ... examined the effect of deletion of the
components of the PDZ binding motif on the signal-
ing properties of the receptor in Ca
2+
imaging
experiments. Truncation of the...
Tài liệu Báo cáo khoa học: Protein kinase CK2 activates the atypical Rio1p kinase and promotes its cell-cycle phase-dependent degradation in yeast pdf
... at the
RIO1 locus under the control of the RIO1 promoter) were
generated using yeast strain YMA69 (Mat a, rio1::HIS3,
ade 2–1 , his 3–1 1, 15, leu 2–3 , 112, trp 1–1 , ura 3–1 , can 1–1 00
[pMA 221]). The ... carrying the respective myc
3
-tagged RIO1-
alleles under the control of the GAL10 promoter in the
genomic context (the respective alleles were integrated at...
Báo cáo khoa học: Protein aggregation and amyloid fibril formation prediction software from primary sequence: towards controlling the formation of bacterial inclusion bodies pot
... of
a4v over the entire sequence defines the aggregation
profile of the polypeptide. The hot-spot threshold
(HST) was defined as the average of the a3v of the 20
natural amino acids weighted by their frequencies ... residue of the protein, equal to the
average packing density value observed for this type of
residue; then, the obtained values are averaged inside
the window a...
Báo cáo khoa học: Protein–protein interactions and selection: generation of molecule-binding proteins on the basis of tertiary structural information potx
... describes the methodology for
elucidating protein protein interactions and selecting
specific binders to novel target proteins, and the first
and second minireviews focus on the detection of
protein protein ... inde-
pendently of scaffold proteins. The generation of
recombinant binding proteins by library approaches
will supply new insights into protein protein interac-
tions, and...
Báo cáo khoa học: Protein transport in organelles: The Toc complex way of preprotein import pdf
... post-translational import of
preproteins into the chloroplast. Three components, the Toc34 and Toc159
GTPases together with the Toc75 channel, form the core of the Toc com-
plex. The two GTPases act as ... photosyn-
thesis (termed ‘photosynthetic proteins’), suggesting
that both atToc33 and atToc159 are involved in the
import of photosynthetic proteins. However, the
reduced ac...
Báo cáo khoa học: Protein transport in organelles: The composition, function and regulation of the Tic complex in chloroplast protein import pptx
... the
membrane. The position and function of the long
C-terminal tail on the other hand remains a matter of
controversy [10,11,1 3–1 5]. According to one hypothe-
sis, the hydrophilic Tic110-Ct faces the stroma, ... hypothesized that the protein exists in a
closed conformation, in which the TPR domain
shields the Hip/Hop-domain from the chaperone.
Surprisingly, the TPR...
Báo cáo khoa học: Protein transport in organelles: Protein transport into and across the thylakoid membrane pptx
... SecY [8]. In the bacterial system, the signal
peptide of the preprotein interacts post-translationally
with SecA in the cytoplasm. The SecA–preprotein com-
plex associates with the Sec core components ... with the
precursor–receptor complex and the putative translocase is formed.
(iii) The precursor protein is then transported in a process energized
by the DpH across th...
Báo cáo khoa học: Protein transport across the endoplasmic reticulum membrane pdf
... detergent.
Membrane protein integration
During the synthesis of a membrane protein, hydro-
phobic TM segments move from the aqueous interior
of the channel through the lateral gate into the lipid
phase. The ... a
loop into the channel, such that the signal sequence
is intercalated into the walls of the channel and the
segment distal to it is inserted into the pore p...