Báo cáo khoa học: MicroRNAs and the regulation of fibrosis potx

... within the 3¢-UTR of target genes. The specificity of the miRNA guide strand is thought to be mediated by the ‘seed’ region localized between resi- dues 2 and 8 at the 5¢ end [5–7], and the specificity ... of organs including the heart, kidney, liver and lung. In this review, we summarize our current understanding of the role of miRNAs in the development of t...

Ngày tải lên: 15/03/2014, 11:20

... DNA damage response. Dysregulation of the DNA damage response leads to genomic instability and cancer. Dependent on the cellular background and extent of DNA damage, the DNA damage response trig- gers ... on the apoptotic signalling routes of the DDR regulated mainly from the cell nucleus and the key molecules p53, p73 and homeodomain-interacting protein kinase 2 (...

Ngày tải lên: 16/03/2014, 00:20

... ATP-dependent manner [20]. Next, one strand (the passenger strand) of the miRNA is removed from the RLC, whereas the other strand (the guide strand) remains in the complex to form a mature RNA-induced ... both the BTG4 gene and the miR-34b ⁄ c polycis- toron [28]. Thus, miR-34b ⁄ c expression may be regulated by both the promoter of the host gene and the promoter i...

Ngày tải lên: 14/02/2014, 19:20

... summarize the current understanding of miRNA function in the heart and outline details of what is known about their puta- tive targets. In addition, we review several aspects of the regulation of miR ... activities of the heart (i.e. the rate and force of contraction of the heart) are orchestrated by multiple categories of ion channels, which are trans- membr...

Ngày tải lên: 14/02/2014, 19:20

... hypoxanthine and guanine is only 0.26% and 0.09%, respectively, of the activity of HPRT, the role of the PRTFDC1 in purine metabolism remains unclear and it is uncertain whether it has the capacity to ... interacts with both O6 and N7 (Fig. 1C). The 2¢OH of the ribose is hydro- gen bonded to the main chain and the side chain of Asp142 (Fig. 1C). Both hydrox...

Ngày tải lên: 15/02/2014, 01:20

... hinge domains The composition of the two hinges that connect the FMN subdomain in NOS enzymes (H1 and H2 in Fig. 5) defines the allowable movements of the FMN subdomain and thus controls the FMN–NOSoxy ... changing the ratio or speed of k 1 and k 2 , changing the rate of FMNH 2 formation or by a combi- nation of these effects. In addition, further tuning could b...

Ngày tải lên: 18/02/2014, 11:20

... the lack of domain B protruding out of the TIM barrel in the place of loop 3 connecting the b3-strand to the a3-helix [9,21]. Sharing domain B by rBATs and GH13 enzymes, and especially the sequence of ... extracellular domain. The segments correspond, in fact, with some of the a-amylase family CSRs, namely the b-strands b2, b3, b4 and b8 of the (b ⁄ a) 8...

Ngày tải lên: 18/02/2014, 13:20

... important role in the regulation of cellular pro- cesses in plants and mammals. Moreover, they are an essential tool in the synthesis of phospholipids and phospholipid analogs. Knowledge of phos- pholipase ... illustrates the quality of the experimental data (Fig. 2B). Reconstruction of the overall shape of the PLDa2 from the X-ray scattering data was achieved...

Ngày tải lên: 19/02/2014, 02:20

... and ^ represent parallel and perpendicular polarized light, respectively. The bottom panel displays the result of deconvolution of the IR absorption spectrum of the peptide f or analysis of the ... at a scanning rate of 50 nm Æmin )1 with a time constant of 2 s, step resolution of 0.1 nm, and bandwidth of 1 nm. The final spectra were taken from the average...

Ngày tải lên: 19/02/2014, 16:20

... [57]. Isolation and cloning of the SynMGST and E.coliMGST The coding sequence for the SynMGST, corresponding to the complementary strand of the nucleotide sequence from 89 254 to 89 667 in the Synechocystis ... of the predominant band displaying the correct molecular mass, purified from the gel, yielded the expected sequence. The partially purified protein consti...

Ngày tải lên: 19/02/2014, 17:20