Báo cáo khoa học: Effects of thymoquinone on isolated and cellular proteasomes pot

... al. Thymoquinone inhibits proteasome functionality FEBS Journal 277 (2010) 2128–2141 ª 2010 The Authors Journal compilation ª 2010 FEBS 2141 Effects of thymoquinone on isolated and cellular proteasomes Valentina ... work, the effects of TQ on protea- some functionality were investigated both in isolated and in cellular complexes. For this purpose, constitu- tive...

Ngày tải lên: 15/03/2014, 11:20

... formula: ½TK¼ ½T½K T  ½TþK M ð1Þ where [T] and [K T ] are the free target concentration and total kinase concentration, respectively, and K M is the Michaelis–Menten constant of the kinase. The con- centration of the complex ... of the kinase (G–I). (A) Contour plot of the response coefficient R T Ã K T as function of the total concentration of the phosphatase and the k...

Ngày tải lên: 19/02/2014, 07:20

... as positive controls. The subcellular distribution of PLD and the conse- quences of priming and activation were determined using immunoprecipitation and Western blot analysis of neutro- phil cytosol and ... significant inhibition of O À 2 generation and [ 3 H]PtdBut accumulation over untreated controls. Inserts show the concentration effects of brefeldin A or wortmannin on...

Ngày tải lên: 07/03/2014, 15:20

... inhibition results in the inhibition of IFN-c and IL-4 production, interference with IL-4 promoter activity and impairment of the interaction between PRMT1 and NIP45. Several lines of evidence strongly ... methylation reac- tions using calf thymus histones as a source of the PRMT1 substrates histone 4 and histone 2A [18]. Inhi- bition by both compound 4 and AMI-1 was relieve...

Ngày tải lên: 06/03/2014, 11:20

... Proceedings of the 12th Conference of the European Chapter of the ACL, pages 238–245, Athens, Greece, 30 March – 3 April 2009. c 2009 Association for Computational Linguistics Effects of Word Confusion ... the effect of this improvement on the search task and demonstrate the benefit of tighter coupling of ASR and the query parser on search accuracy. The paper outline i...

Ngày tải lên: 08/03/2014, 21:20

... study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin and hesperidin in a double-blinded, randomized, place- bo-controlled protocol with 10 ... Nutr. 2006; 136: 404-408. 3. Bredsdorff L, Nielson IL, Rasmussen SE, et al. Absorption, conjugation and excretion of the flavonones, naringenin and hesperetin from alpha-rhamnosi...

Ngày tải lên: 25/10/2012, 11:04

... 1. Department of Thoracic Surgery, Konya Education and Research Hospital, Konya, Turkey; 2. Microbiology Laboratory, Konya Education and Research Hospital, Konya, Turkey  Corresponding author: ... and additional analgesic consumption. These findings may be related to the antiinflammatory effects of flurbiprofen. VAS scoring is a simple and often used method for evaluatin...

Ngày tải lên: 25/10/2012, 11:10

... dependent on the inhibition of gap junctional communication and thus the proliferation of vascular smooth muscle cells. Intima of artery has mutual communication be- tween cells and between cells and ... expression of Cx40 and Cx43 in the artery at early stage of high fat diet induced atherosclerosis and to investigate the effects of AT1 antagonist Losartan on t...

Ngày tải lên: 26/10/2012, 09:39

... several cytoplasmic ligands. It is activa- ted by millimolar concentrations of ATP and micromo- lar Ca 2+ , and inhibited by higher concentrations (> 100 lm)ofCa 2+ and by millimolar Mg 2+ . ... Ca 2+ -dependent mechanisms and several studies describe direct effects of these ions on Ca 2+ -binding or calcium ion conduct- ing membrane proteins. Lanthanide ions were found to...

Ngày tải lên: 19/02/2014, 16:20

... ion toler- ance of ± 3 m ⁄ z, a peptide ion tolerance of ± 3 m ⁄ z, one missed cleavage, fixed carbamidomethylation of cysteines and variable oxidation of methionines were specified. Purification ... relies on a multitude of guidance cues to stimulate axonal exten- sion and stable synaptic contacts with targets such as muscles. Interpretation of these environmental signals by g...

Ngày tải lên: 19/02/2014, 05:20