Báo cáo khoa học: Heme oxygenase-1 ⁄p21WAF1 mediates peroxisome proliferator-activated receptor-c signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells pot

... Heme oxygenase-1 ⁄ p21 WAF1 mediates peroxisome proliferator-activated receptor-c signaling inhibition of proliferation of rat pulmonary artery smooth muscle cells Manxiang Li 1 , ... January 2010) doi:10.1111/j.1742-4658.2010.07581.x Activation of peroxisome proliferator-activated receptor (PPAR)-c sup- presses proliferation of rat pulmonary a...

Ngày tải lên: 15/03/2014, 10:20

... cytoki- nesis has offered a third possible explanation for the tumour suppressor activity of this enzyme complex [73]. Inhibition of PI3K-III activity not only causes an increased proportion of cells undergoing ... metabolized through the activities of a num- ber of substrate-specific PI kinases and phosphatases, the dysfunctions of which are associated with various human disea...

Ngày tải lên: 06/03/2014, 01:23

... side of the dimer. Overall, the analysis of IGF-II binding in such receptor dimers suggests that each half of the dimer is capable of binding IGF-II independently of the ligand occupancy of the ... number of wild-type binding sites avail- able in a mixture of mutant ⁄ wild-type receptors. Tethering to the resin of asymmetric heterodimers sug- gests the importance of anchor...

Ngày tải lên: 18/02/2014, 08:20

... Department of Pharmacy, University of Tromsø, Norway 2 Department of Medical Biochemistry, University of Tromsø, Norway 3 School of Pharmacy, University of Oslo, Norway 4 Department of Tumor Biology, ... number of via- ble cells were observed for both cell lines attached to plastic. However, when the cells were attached to monomeric 2D collagen, the number of viable cel...

Ngày tải lên: 18/02/2014, 11:20

... units of guanylate kinase and 2 units of pyruvate kinase in a total volume of 0.5 mL, and were incubated for 30 min at 37 °C in order to generate the reductase substrate 3 (the addition of guanylate ... structure. Quantitative analysis of the signal integrals reveals rapid consumption of the b anomer and less rapid con- sumption of the a anomer of substrate 3. All data are in...

Ngày tải lên: 18/02/2014, 18:20

... scale of potential reactivity to cisplatin [6,7]. Expression of the p53 downstream effectors in cisplatin-treated cells may thus be entirely unbalanced rather than shifted towards one of the response ... fragment caused about 70% inhibition of p53(1–363) binding to either of the two targets. Modi- fication of the p21 ⁄ pPGM1 mixture resulted in r b -dependent inhibition of...

Ngày tải lên: 19/02/2014, 05:20

... low activity of the Plsp1 homolog that is responsible for full maturation of Toc75 in the pea Fig. 1. The biogenesis of pea Toc75. The precursor, intermediate, and mature forms of Toc75 are indicated ... by which the polyglycine stretch mediates envelope targeting of Toc75 remains unknown. In this report, we extended the analysis of the poly- glycine stretch of the Toc75 trans...

Ngày tải lên: 19/02/2014, 07:20

... mechanism of inactivation of GPAO by DAPY, we investigated the inhibitory potency of the two possible mo no-N-methyl derivatives of DAPY with Fig. 9. Mechanism of DAPY oxidation by GPAO. The scheme ... for half of the enzyme to become inactivated in the presence of saturating concentration of inhibitor. b In 0.1 M Bistris/ HCl buffer, pH 7.0. Fig. 2. Partition ratio plot for in...

Ngày tải lên: 19/02/2014, 16:20

... that mediates the insertion of four additional nucleotides into a predetermined position of a substrate RNA, and thus mimics, at the RNA level, the repair of a short deletion mutation; 17% of the ... the insertion of four specific nucleotides into a predetermined site of an arbitrarily defined substrate RNA as illustrated in Fig. 2A. In the ribozyme– substrate complex, a stretch...

Ngày tải lên: 20/02/2014, 01:20

... two types of word chains. Each chain consists of longest matching sequences of words with the same PoS class, namely noun chains or verb chains, where an element of a noun chain belongs to one of the ... demonstrated the effectiveness of this hypothe- sis for web–based question answering. Finally, we compute the frequencies of each chunk, each chunk pair, and each chunk pair dis...

Ngày tải lên: 20/02/2014, 05:20