Báo cáo khoa học: b-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins pot

... cells did not show any effect of POSH on Rac1L61 ubiquitination and therefore do not support this hypothesis. Except for a recent report on the role of protea- some-mediated degradation of Rac1–GTP ... apparently not used for ubiquitin addition. Therefore, the reason why Lys147 rather than Lys5 is the main acceptor site for ubiquitin in Rac1 remains to be elucidated....

Ngày tải lên: 18/02/2014, 16:20

... Schlott for performing the MA analysis. This work was supported by the Deutsche Forschungsgemein- schaft (SFB 604). The Leibniz Institute for Age Research is funded by the State of Thuringia and the Bundesministerium ... cells. Indeed, the stabilizing residue methionine is found at the N-terminus of the human Cdc45 protein (NCBI NP 003495). This is in accordance...

Ngày tải lên: 19/02/2014, 00:20

... This raises the question of whether KIPase is a member of the caspase family or not. Here we have demonstrated that KIPase is distinct from human caspases 1–10. The evidence supporting this is ... distinct routes to apoptosis. This resulted in a slower induction of apoptosis with the peak of the activities of the apoptotic caspases activity evident 24 h post ex...

Ngày tải lên: 19/02/2014, 13:20

... pressure on this sequence and supporting the hypothesis that this part of the mRNA is translated. Eleven exons encode the ORF of human Hu-K4 (Fig. 4A, exon 5–15). The analysis of more than 100 GenBank ... with known function, the most abundant viral protein p37 (21%). Other members of the HKD superfamily are the phospholipase D iso- forms. Like the other proteins s...

Ngày tải lên: 19/02/2014, 17:20

... who were either doctors or dentists and who lived in either Michigan or Pennsylvania. This is the state of our art? Instead of assuming that the problem is one of using typed English to access ... this panel, which is supposed to debate the necessity of continuing work in this area rather than to debate technical issues in the area. And yet if this problem has bee...

Ngày tải lên: 21/02/2014, 20:20

Ngày tải lên: 21/02/2014, 20:20

... pro- pose that glycosylation is important for the folding of HFE and is essential for transport and exit of the pro- tein from the ER. The importance of glycosylation is cumulative, however, with ... Fleming JV & Wang TC (2003) The production of 53–55-kDa isoforms is not required for rat l-histidine decarboxylase activity. J Biol Chem 278 , 686–694. N-G...

Ngày tải lên: 06/03/2014, 22:21

... over- expression of XGld2 D242A (Fig. 3D) did not affect the translational activation by MS2-XRbm9. More- over, the overexpression of the wild-type form of XGld2 did not potentiate the stimulation of the U1A MS2 MS2-PAB MS2-XRbm9 MS2-U1A Tubulin Reticulocytes ... the binding. These data suggest that a domain surrounding amino acid 269 is important for the inter...

Ngày tải lên: 07/03/2014, 05:20

... 25°C. This material is available as part of the online article from http://www.blackwell-synergy.com Please note: Blackwell Publishing is not responsible for the content or functionality of any ... fow- licidins-1–3 [12]. On the basis of the conserved ela- stase cleavage site present in the precursor sequences, we predicted that mature forms of fowlicidins-1–3 ar...

Ngày tải lên: 07/03/2014, 11:20

... s q is ordered before the other senses then we can expect s q to be the dom- inant sense for this word. We include features like size of the sense and order of the sense. Part of speech of s q is ... common in English. It is estimated that average polysemy of English is more than 2 and average polysemy of common English words is much higher (around 4). Thus, it...

Ngày tải lên: 08/03/2014, 01:20