Báo cáo khoa học: Voltage-gated sodium channel isoform-specific effects of pompilidotoxins doc

... sites, most of them still lack experimental approaches directed at identifying the exact mechanism involved. In spite of the well-known lack of reliability of in silico approaches, many of the synonymous ... recognition of splicing regulatory sequences [1,2]. This could result in altered isoform proportions, activation of a control mechanism such as nonsense-mediated decay, as w...

Ngày tải lên: 06/03/2014, 09:22

... significance is often indicated by Term Frequency (TF) and Inverse Document Fre- quency (IDF). The usage of TF comes from “the simple notion that terms which occur frequently in a document may ... occur both in a text document and its corresponding abstract as Co- occurring NPs (CNPs). 4.1 CMP-LG Corpus In our experiment, a corpus of 183 documents was used. The documents are from t...

Ngày tải lên: 23/03/2014, 19:20

... semantic model of a multimodal document. We discuss the type of model required, the means by which it can be constructed, how the content of the model is rated and selected, and the method of realizing novel ... high-quality summaries of relatively simple articles, there are limitations as to the types of documents these systems can handle. One such limitation is the summarization...

Ngày tải lên: 30/03/2014, 21:20

... authors. Pompilidotoxins and voltage-gated Na v isoforms E. Schiavon et al. 930 FEBS Journal 277 (2010) 918–930 ª 2010 The Authors Journal compilation ª 2010 FEBS Voltage-gated sodium channel isoform-specific ... sequence of each isoform. Effects on the sodium currents of Na v 1.6 are characterized by a robust voltage-dependent steady-state component and the absence of th...

Ngày tải lên: 15/03/2014, 10:20

... probabilistic noisy- channel model for question answering and we show how it can be exploited in the context of an end-to-end QA system. Our noisy -channel system outperforms a state- of- the-art rule-based ... abundance of distinct questions (Quiz-Zone) contribute to the diversity of a QA training corpus, and implicitly to the performance of our system. 5 Framework flexibi...

Ngày tải lên: 08/03/2014, 04:22

... probabilityof a document given a summary , and , the probability of a summary. We assume that we are given the discourse structure of each document and the syntactic structures of each of its EDUs. The ... discourse structure of a document and the syntactic structure of each of its sentences or EDUs. It then compresses the document by dropping either syntactic or dis- course con...

Ngày tải lên: 08/03/2014, 07:20

... source -channel models of Chinese sentence generation, with two components: a source model and a set of channel models. The source model is used to estimate the generative probability of a word ... improved source -channel models, which contains one context model (i.e., a trigram language model in our case) and a set of class models of different types, each of which is...

Ngày tải lên: 31/03/2014, 03:20

... remit of the local ethics committee. Prior to introduction of CPOE, local standards of prescribing existed specifying the tenets of good practice, including the avoid- ance of the use of abbreviations. An ... administered as Table 1 Types of medication errors before and after implementing CPOE Error type HWP (no. of errors and % of total errors) a CPOE (no. of errors and %...

Ngày tải lên: 25/10/2012, 10:39

... Heinrich R & Rapoport TA (1973) Linear theory of enzymatic chains; its application for the analysis of the crossover theorem and of the glycolysis of human ery- throcytes. Acta Biol Med Ger 31, ... the effects of ethanol stress. In particular, the ratio between the kinetic constants associated with ethanol production and glucose consumption gave the estimation of the metabol...

Ngày tải lên: 14/02/2014, 14:20

... A 340 as a result of NADH oxidation was measured. One unit of enzyme activity was defined as the reduction of 1 lmolÆmin )1 of NADH (corresponding to the carboxylation of 1 lmolÆmin )1 of acetyl-CoA). Quantification ... addition of CoA solution). The K m value for CoA of the OGOR enzyme is reported to be 80 lm [30]. Thus, decarboxyl- ation of 2-oxoglutarate can proceed as a re...

Ngày tải lên: 16/02/2014, 09:20