Báo cáo khoa học: Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting pdf

... -9, -11 and -19) and ADAM12 cleave IGF-binding Fig. 1. Pivotal roles of MMPs in cancer progression. Cancer progression involves different stages, including tumor growth and the multistep processes of ... [52,53]. Pharmacological targeting of matrix metalloproteinases On the basis of the pivotal roles that MMPs and ADAMs play in several steps of cancer...

Ngày tải lên: 15/03/2014, 00:20

... exam- ine the roles of the conserved arginines, Arg322 (P2) and Arg323 (P1) of AAA-1, and Ar g747 (P1) of AAA- 2, and determined that the arginines of TClpB are not involved in nucleotide binding ... these three arginines in TClpB. By combining an arginine mutation with the WalkerA mutation in the other AAA+ module, we tested the roles of the arginines in ATP bindi...

Ngày tải lên: 06/03/2014, 00:20

... hepatic protein binding of quinine and quinidine. Accumulation of quinine and quinidine (5 l M ) in rat hepatocytes is expressed as the steady state ratio (C/M) between cell associated and extracellular ... concentration. Determination of drug binding to hepatic proteins For the determination of the liver tissue binding of [ 3 H]quinine and [ 3 H]quinidine, rat liver was h...

Ngày tải lên: 31/03/2014, 07:20

... domain at their C-terminus, and a less conserved proline-rich and glutamine-rich transactiva- tion domain at their N-terminus [8–10]. Most isoforms also have a PY-motif (XPPXY) in the N-terminal ... role of AP-2a and AP-2e in chondrogenesis. Overview of the differen- tiation stages during chondrogenesis and the involvement of transcription factors (henatoxylin and eosi...

Ngày tải lên: 16/02/2014, 09:20

... section and scheme of the coronal section at E14.5 in (F). (A) At E11.5, HSF2 is expressed in forebrain, midbrain and in hindbrain except for the midbrain, hindbrain midline. Surprisingly, the ... would enhance or diminish the impact of HSF2 deficiency. Pending questions for the roles of HSF1 and HSF2 in oogenesis and in early embryos The role of HSF2 in oogenesis...

Ngày tải lên: 18/02/2014, 04:20

... within the L1 loop with alanine, a short side chain amino acid, significantly decreased the DNA-binding ability of human Rad51, without affecting the protein fold- ing or the salt-induced, DNA-independent ... significant defects in ssDNA binding and dsDNA binding A B Fig. 3. The DNA binding activities of the Rad51 mutants. (A) The ssDNA binding experiments. The /X174 circular ssDNA (40...

Ngày tải lên: 19/02/2014, 06:20

... application of SH2 domain binding peptides, which results in blocking of the binding of the SH2 domain to the substrate and thereby preventing interaction of the substrate with the kinase domain. For ... demonstrated that intra-domain interactions between Src family kinases (SFKs), stabilized by binding of the phosphorylated C-terminus to the SH2 domain and ⁄ or binding of t...

Ngày tải lên: 06/03/2014, 01:20

... that only a trace of the pro- tein was left in the unbound fraction. Pre-incubation of the recombinant protein with FP abolished most of this binding, suggesting that binding of rPf1-Cys-Prx to ... the original activity (–). HG indicates inactivation reactions containing FP and GSH. HGP and HGaP indicate inactivation reactions containing HG + rPf1-Cys-Prx and HG + autoclaved r...

Ngày tải lên: 07/03/2014, 17:20

... processing of one or several nuclear proteins, whereas the other is independent of the processing capacity of the protein- ase and involves the HPX domain. A DNA-binding domain was found in the ... disease: roles of matrix metalloproteinases in cancer progression and their pharmacological targeting. FEBS J 278, 16–27. 16 Tchougounova E, Lundequist A, Fajardo I,...

Ngày tải lên: 15/03/2014, 00:20

... physical and chemical agents, including UV and c-irradiation, heterocyclic N-oxides of the tirapazamine family, organometallic oxidants and the anticancer antibiotics (such as neocarzinostatin) of the ... path- ways. In this model, the removal of 5¢-dRp, which appears to be the late-limiting step in short-patch BER [64], may be critical in determining the mode of BER. DNA–...

Ngày tải lên: 16/03/2014, 13:20