Báo cáo khoa học: Enzymes of mannitol metabolism in the human pathogenic fungusAspergillus fumigatus– kinetic properties of mannitol-1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications pot

... metabolism in the human pathogenic fungus Aspergillus fumigatus – kinetic properties of mannitol- 1-phosphate 5-dehydrogenase and mannitol 2-dehydrogenase, and their physiological implications Stefan ... M2DH Interpretation of the kinetic properties of an enzyme in the context of its role in cellular metabolism relies on knowledge of the...

Ngày tải lên: 14/03/2014, 23:20

... role in the maintenance of cell survival, but is also responsible for the up-regulation of glucose metabo- lism and the induction of lipogenesis [37–40]. We hypothesized that signaling via the ... HIF-1a is involved directly in the accumulation of lipids trig- gered by QDs under the conditions of uncompromised cell survival in the presence of serum. On the...

Ngày tải lên: 07/03/2014, 00:20

... kinetically in uential ionizations were identified in plots of k lim ⁄ K d of pK a values 7.1 and 9.3, again with the maximum value realized in the alkaline region. The poten- tial origin of these kinetically ... substrate carbinolamine intermediate; III, iminoquinone intermediate; IV, product Schiff base intermediate; V, aminoquinol intermediate. In the oxidative half-r...

Ngày tải lên: 19/02/2014, 07:20

... December 2010) doi:10.1111/j.1742-4658.2010.07980.x The escalating prevalence of obesity is one of the most pressing health concerns of the modern era, yet existing medicines to combat this global pandemic are disappointingly limited in terms ... cyclin ⁄ cyclin-dependent kinase holoenzymes, releasing the E2F complex and thereby resulting in activation of the E2F targe...

Ngày tải lên: 06/03/2014, 01:20

... SRE fos and SRE Gfos , on the one hand, and SRE GGfos , on the other hand, consists in the distinct strains acting on the helix ply of these oligonucleotides. Conversion between the bent and linear ... tem- peratures. The increase in intensity of the 926 (924), 1444 and 1462 cm )1 vibrational bands of deoxyribose and of the 790 and 1056 cm )1 bands of...

Ngày tải lên: 07/03/2014, 09:20

... already present in the LSP grammar. Figure 1 shows a sample definition and the triples the parser found in it. ABDOMEN 0 1 N THE PART OF THE BODY BETWEEN THE THORAX AND THE PELVIS (THE) pmod ... the node to the right of the taxonomy marker 'W") serving as a pointer to its own defining node. The resulting network is quite dense. We simplify b...

Ngày tải lên: 08/03/2014, 18:20

... described for the sulfuration of the C-terminal glycine in ThiS and MoaD, involved in thiamine biosynthesis and molyb- dopterin biosynthesis, respectively, and for the sulfura- tion of uridine in tRNA ... phenylalanine instead of a tyrosine directly before the thioglycine (Methanoculleus thermophilus and Methanosarcina barkeri) or directly after the thioglycine (...

Ngày tải lên: 16/03/2014, 05:20

... Therefore, the incoming Na + ion is thought to weaken the rather strong interaction between the arginine and the bind- ing site and to promote its loading onto the binding site, aided by the membrane potential ... arriving from the periplasm from escaping to the cytoplasm. In order to gain insight into the interaction of the stator arginine with the binding site,...

Ngày tải lên: 16/03/2014, 06:20

... contribute to the induction of oxidative stress during ischemia ⁄ reperfusion in brain. There is a growing body of information concerning the mechanism of ROS generation by the respiratory chain in mitochondria. ... this treatment. The high degree of protection by ADP sug- gests that the mitochondrial injury is caused by open- ing of the mPTP. There is evidence that...

Ngày tải lên: 16/03/2014, 22:20

... positioning of CA. Mutation of all arginines led to a significant loss in protein stability suggesting that they are involved in protein fold structure rather than binding of the substrate. The overall ... explain the complete impairment of substrate binding and the increased stability of the mutant protein. The orientation and size of SRS 6 is quite variable be...

Ngày tải lên: 17/03/2014, 10:20