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Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx

Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx

Báo cáo Y học: Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells docx

... Effects of ATP depletion and phosphate analogues on P-glycoprotein conformation in live cells Katalin Goda1, Henrietta Nagy1, Eugene Mechetner2, Maurizio Cianfriglia3 and Ga´bor ... accompanied bycomplementary changes in MM12.10 binding also in re-sponse to direct modulation of the ATP- binding site, con-firming that conformational changes intrinsic to the catalyticcycle are ... Vitrapping of Pgp also occurs in live cells. Coupling of Pgp-mediated drug transport and ATP hydrolysis are generally interpreted in terms of ligand-induced ATPase activation and concomitant...
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Báo cáo khoa học: Effects of the G376E and G157D mutations on the stability of yeast enolase – a model for human muscle enolase deficiency pdf

Báo cáo khoa học: Effects of the G376E and G157D mutations on the stability of yeast enolase – a model for human muscle enolase deficiency pdf

... Substi-tuting any amino acid at this position would result in a change in the conformation of this loop. Changes in the conformation of the backbone at this point and changes in the orientation of other ... stability of yeast enolase – a model for human muscle enolasedeficiencySongping Zhao*, Bonny S. F. Choy* and Mary J. KornblattDepartment of Chemistry and Biochemistry, Concordia University, Montreal, ... mutations changedglycine 156 to aspartate and glycine 374 to glutamate. In order to studythe effects of these changes on the structure and stability of enolase, wehave introduced the corresponding...
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Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers ppt

Báo cáo khoa học: Effects of sphingomyelin, cholesterol and zinc ions on the binding, insertion and aggregation of the amyloid Ab1)40 peptide in solid-supported lipid bilayers ppt

... Journal compilation ª 2006 FEBS Effects of sphingomyelin, cholesterol and zinc ions on thebinding, insertion and aggregation of the amyloid Ab1)40peptide in solid-supported lipid bilayersSavitha ... thepresence and absence of added zinc ions. This methodo-logy has previously been used in our laboratory tocharacterize the composition of, the formation of, and insertion into, microdomains in bilayer ... a time period of  15 h), indicating that no peptide aggregationoccurred during this interval.The addition of Ab to a lipid bilayer containing onlySM again resulted in increasing spectral shifts...
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Báo cáo y học: "Effects of p-Synephrine alone and in Combination with Selected Bioflavonoids on Resting Metabolism, Blood Pressure, Heart Rate and Self-Reported Mood Changes"

... multiple ingredients. The current study assessed the thermogenic effects of p-synephrine alone and in conjunction with the flavonoids naringin and hesperidin in a double-blinded, randomized, ... conditions remains to be deter-mined. The mechanism by which naringin and hesperi-din increase the thermogenic effect of p-synephrine may involve enhancing the expression of adiponectin which ... participants were randomly assigned to one of the five dou-ble-blinded treatment conditions in which they con-sumed one ounce of V-8 juice containing the following ingredient variations: Group 1:...
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Báo cáo y học: "Effects of Flurbiprofen on CRP, TNF-α, IL-6, and Postoperative Pain of Thoracotomy"

... Department of Thoracic Surgery, Konya Education and Research Hospital, Konya, Turkey; 2. Microbiology Laboratory, Konya Education and Research Hospital, Konya, Turkey  Corresponding author: ... proteins. Proinflammatory cy-tokines induce not only a local inflammation at the site of injury, but also systemic responses such as tachycardia, tachypnea, leukocytosis, and pyrexia (1). Increased ... evaluating variations in pain intensity. Subjects are instructed to indicate the intensity of the pain by marking a 100-mm line anchored with terms describ-ing the extremes of pain intensity....
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Báo cáo y học: "Effects of Losartan on expression of connexins at the early stage of atherosclerosis in rabbits"

... expression of Cx40 and Cx43 in the artery at early stage of high fat diet induced atherosclerosis and to investigate the effects of AT1 antagonist Losartan on the Cx43 and Cx40 expression in the ... partly dependent on the inhibition of gap junctional communication and thus the proliferation of vascular smooth muscle cells. Intima of artery has mutual communication be-tween cells and ... 85Immunocytochemistry The relatively low expression of Cx43 and Cx40 in VSMCs and endothelial cells was observed in the normal group. However, the expression of Cx43 and Cx40 in the intima and...
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Báo cáo y học: "Impact of the Kenya post-election crisis on clinic attendance and medication adherence for HIV-infected children in western Kenya"

... sampling to iden-tify key informants, including physicians, nurses, and clinical officers, based on their locations and roles duringthe conflict. A trained facilitator conducted 9 interviewsusing ... Board of the IndianaUniversity School of Medicine (Indianapolis, Indiana).Informed consent was obtained for key informant inter-views, and all clinical investigation was conducted accord-ing ... used by involving additional investiga-tors in reviewing the recordings and field notes and in confirming or disconfirming the codes and the subse-quent themes. Data triangulation was used by comparingthe...
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Báo cáo y học:

Báo cáo y học: "Characterization of Human Erythrocytes as Potential Carrier for Pravastatin: An In Vitro Study"

... loading of pravastatin into erythrocytes was directly proportional with increase of drug concentration in the incubation medium, in the 2-10 mg/ml concen-tration range. This finding is in concurrence ... suspension are added to 400 µl of PBS containing the known concentration of the drug and 2.5 mmol of ATP, 2.5 mmol MgCl2 and 2.5 mmol of CaCl2, gently mixing to avoid hemolysis and incubation ... pravastatin concentration and incubation time on the amount of pravastatin loaded on human carrier erythrocytes at 25oC by endocytosis Drug concentra-tion(µg/ml) Drug incubation times 15 min....
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Báo cáo y học:

Báo cáo y học: "Changes of uterine blood flow after vaginal radical trachelectomy (VRT) in patients with early-stage uterine invasive cervical cancer"

... of no signs of threatened abortion. Daily vaginal disinfection with popidone iodine, bed rest, and administration of ritodrine and an ulinastatin vaginal suppository were continued as a new ... insemination. She was admitted to our hospital with a diagnosis of threatened abortion at 17 weeks of gestation. In spite of bed rest, disinfection therapy, and the administration of ritodrine, ... imaging of a patient with normal uterus after the delivery. A: Ascending branch of right uterine artery. B: Ascending branch of left uterine artery. C: Descending branch of right uterine artery....
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Báo cáo y học:

Báo cáo y học: "Efficacy of Sirolimus-Eluting Stents Compared With Paclitaxel-Eluting Stents in an Unselected Population With Coronary Artery Disease: 24-Month Outcomes of Patients in a Prospective Non-randomized Registry in Southern Turkey&

... University School of Medicine, Department of Cardiology, Antalya, Turkey; 2. İnönü University School of Medicine, Department of Cardiology, Malatya, Turkey; 3. Erciyes University School of Medicine, ... randomiza-tion, and relatively low compliance with angiographic follow-up. CONCLUSIONS On the basis of the clinical results of this 24-month study, one might reasonably conclude that treating with ... lesions involving the left main coronary artery,3 in- stent restenosis,4 Int. J. Med. Sci. 2010, 7 http://www.medsci.org 192chronic total occlusion,5 and acute myocardial infarc-tion.6...
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