Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile pdf
Báo cáo Y học: Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile pdf
... Fluorescent analogs of UDP-glucose and their use in characterizing substrate binding by toxin A from Clostridium difficile Sudeep Bhattacharyya, Amy Kerzmann and Andrew L. FeigDepartment of ... sugar complexes for use in studying glycosyl-transferases in general and TcdA in particular. These substrate analogs are related to the commercially availablemethylanthraniloyl (mant) derivatives ... thesetoxins has been studied previously [12,13]. TcdA and TcdBshare 43% homology and 63% similarity and aremembers of a family of cytotoxins known as the largeclostridial cytotoxins that also...
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Báo cáo Y học: Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types pptx
... CD53, can have a signalling role by themselves. Natural ligands of CD53 orother tetraspan proteins are not yet known. In a waytetraspanin proteins can be considered as orphan receptors, and consequently ... immunoprecipitate by theincorporation of radioactivity in the GST–ATF2 fusion protein usedas substrate. At the top is the assay of the tran sfected HA-JNK activitydetected in the anti-HA immunoprecipitate ... anti-CD53 and anti-CD3 mAbs at su boptimalconcentrations of anti-CD3. In all cases the extract was precipitatedwith an anti-Vav polyc lonal antibody and developed with an a nti-phosphotyrosine (PY99)...
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Báo cáo Y học: Domain V of m-calpain shows the potential to form an oblique-orientated a-helix, which may modulate the enzyme’s activity via interactions with anionic lipid potx
... divided into domains V and VI. Domain II possesses the active site and is a papain-likecysteine protease domain, and domain IV contains a calmodulin-like Ca2+ -binding domain with multipleEF-hand ... damage, and neurodegenerative con-ditions such as Alzheimer’s and Parkinson’s disease [10,11].The major calpains are l-calpain (calpain 1) and m-calpain (calpain 2), which are ubiquitous in ... snorkelling by an arginine residue located in thepolar face of this a- helix.Keywords: domain V; hydrophobicity gradient; m-calpain;membrane; oblique-orientated a- helix.Calpains are a growing family...
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Báo cáo Y học: Amino acids 3–13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor pdf
... betweenboth assays is the coupling of AR.NTD to GalAD in theyeast assay, and the absence of a second transactivationdomain linked to AR NTD in the mammalian assay. Thelatter assay completely depends ... the23FQNLF27motif in AR N/C interaction, these amino acidswere substituted by 24/25AA. In both the yeast and mammalian protein interaction assay, GalAD-AR.NTD24/25AA and AR.NTD24/25AA formed evenmore active ... GalAD, Gal4 transactivatingdomain; GAlDBD, Gal4 DNA -binding domain; LBD, ligand -binding domain; N/C interaction, interaction between NTD and LBD; NR,nuclear receptor; NTD, N-terminal domain;...
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Báo cáo Y học: The role of hydrophobic active-site residues in substrate specificity and acyl transfer activity of penicillin acylase pdf
... mutagenic primer was 5¢-GGAAATCACACCATTATGACCAAAAACCAGCCCGGGATAGGC-3¢. The underlined codons code for bF24 and bF57 and were changed to ATA, CCA, AGC and CAA tointroduce Tyr, Trp, Ala and ... acylation by PGA in a similar way as theacylation by NIPAB. A notable exception was the twofoldincreased activity for PGA of the aF14 6Y mutant. Itappeared that this mutant had a kcatvalue ... Each phenylalanine was thereforemutated to Ala, Leu, Trp or Tyr. These mutations may in uence the shape and volume of the acyl binding pocket and thereby alter the binding mode and affinity of...
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Báo cáo Y học: Functional integration of mitochondrial and hydrogenosomal ADP/ATP carriers in the Escherichia coli membrane reveals different biochemical characteristics for plants, mammals and anaerobic chytrids pdf
... (NdeIorBglII).aac Oligonucleotide sequenceaac1 (A. t.) Sense 5¢-TGCAGAGTTCcAtATGGTTGATCAAG-3¢Antisense 5¢-CGAAAAAAGGAGGAAGAAGCAATGC-3¢aac2 (A. t.) Sense 5¢-TGTAGAGGTTcAtATGGTTGAACAGACTC-3¢Antisense ... 5¢-TGTAGAGGTTcAtATGGTTGAACAGACTC-3¢Antisense 5¢-CTTAATGACTGCGGGATTTGGTGGTAC-3¢aac3 (A. t.) Sense 5¢-CTGATTTGTACAAcAtATGGATGGATC-3¢Antisense 5¢-GGGCTATTCTTTCATCATCCTCATCG-3¢aac1 (S.t.) Sense 5¢-TTAAACGTTcatATGGCAGATATGAACC-3¢Antisense ... rat, AAC1 from potato and AAC3 from Arabidopsis are much higher thanthose of the AAC1 and AAC2 isoforms from Arabidopsis and AAC1 from rat. The hydrogenosomal AAC from Neocallimastix spec. L2 exhibited...
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Báo cáo Y học: The evolution of monomeric and oligomeric bc-type crystallins potx
... sequences, and of a hydrophobic residue in c-type crystallins.Contrasting results were obtained in another laboratory,showing that a recombinant b-crystallin variant is isolatedas a dimer also when ... presence of spliceosomal introns in eukaryotes, and their absence in archea and in eubacteria [38–40]. Over recent years, a vastamount of data has been interpreted as supporting thistheory [41]. In ... crystallins,respectively.Both monomeric c-type crystallin and the subunit of dimeric b-type crystallin are composed of two domains, anN- and a C-terminal domain (termed N- and C-domains).Each...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... lead concentrations may be increased in patients with CAD. Key words: coronary artery disease; trace element; heavy metal; vitamin INTRODUCTION Coronary artery disease (CAD) is a leading cause ... patients hav-ing angiographically demonstrated CAD and 20 pa-tients having normal coronary arteries attending car-diology clinic at Yuzuncu Yil University Hospital. The study was approved by the ... Research Paper Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease Aysegul Cebi1, Yuksel Kaya2, Hasan Gungor3, Halit Demir4, Ibrahim Hakki Yoruk4,...
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Tài liệu Báo cáo khoa học: "Automatic Identification of Pro and Con Reasons in Online Reviews" ppt
... contain topics in a text have cer-tain positional patterns in a paragraph (Lin and Hovy, 1997), which may apply because reasons like pros and cons in a review document are most important ... you are in a train station or a busy amusement park that is ill-staffed to meet de-mand!”, “preferential treatment given to large groups”, and “they don't offer salads of any kind” are ... evaluation results of our system on Dataset 2. Since Dataset 2 from complaints.com has no training data, we trained a system on Dataset 1 and applied it to Dataset 2. Table 3: Pros and cons...
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Báo cáo khoa học: Differential expression of liver and kidney proteins in a mouse model for primary hyperoxaluria type I pdf
... SpainIntroductionPrimary hyperoxaluria type I (PHI) is a rare autosomalrecessive disease caused by mutations in the alanine-gly-oxylate aminotransferase gene (AGXT). Alanine-glyoxy-late aminotransferase ... favoredover aminobutyrate-pyruvate, b-alanine-pyruvate and dimethylarginine-pyruvate aminotransferase activities. In the rat, gluconeogenesis from l-serine takes placemainly through l-serine dehydratase, ... alanine-glyoxylate aminotransferase 1; AGT2, alanine-glyoxylate aminotransferase 2; AGXT, alanine-glyoxylate aminotransferase gene;Agxt) ⁄ ), alanine-glyoxylate aminotransferase homozygous knockout;...
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Từ khóa: báo cáo y họcbáo cáo y học cổ truyềnbáo cáo khoa học y họcbáo cáo y tế học đườngmẫu báo cáo y tế học đườngbáo cáo y tế học đường cuối nămNghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzđề thi thử THPTQG 2019 toán THPT chuyên thái bình lần 2 có lời giảiGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngTìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThiết kế và chế tạo mô hình biến tần (inverter) cho máy điều hòa không khíTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtBÀI HOÀN CHỈNH TỔNG QUAN VỀ MẠNG XÃ HỘIĐổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ