... synaptosomesBrevetoxin-1 (PbTx-1) from a marine dinoflagellate, inhibitsallosterically the b inding of the s corpion a- tox in, Aah-II, to rat brain synaptosomes [27,28]. To examine the similarity inbinding to ... inhibitory constant;koff, dissociation rate constant; kon, association rate constant; Lqh-II,Lqh-III, LqhaIT, a classical a- toxin, an a- like toxin, and an a- toxinhighly active on insects, ... d-ACTX-Hv 1a occupies a similar position to Asn44 in LqhaIT or Aah-II.Finally, the negatively charged Glu12 in d-ACTX-Hv 1a resembles Glu24 in both LqhaIT and Aah-II.Despite this similarity, the shape...