Báo cáo Y học: Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types pptx
Báo cáo Y học: Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types pptx
... JNK activation by CD53 ligation (Eur. J. Biochem. 269) 1021 Transient activation of the c-Jun N-terminal kinase (JNK) activity by ligation of the tetraspan CD53 antigen in different cell types Mo´nica ... transduction by determining the effect of its ligation on the c-Jun N-terminal kinase (JNK) in different cell types. Ligation of the rat or human CD53 antigen induces a three-to fourfold transient activation ... protein interactions, tetraspanin antigens can in uenceintracellular signalling pathways. The ligation o f CD53 hasbeen shown to induce intracellular calcium mobilization in different cell types, ...
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Báo cáo y học: "Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators"
... aeruginosa at baselinereported in other studies [4-6] because of activity againstkey pathogens. Consideration of the influence of appro-priateness of empiric therapy against subsequently identi-fied ... hazards was tested in eachcase by examining the effect -by- time interaction effectjointly for all covariates, and individually for each covari-ate entered into the model. The proportional hazardsassumption ... was included; the P value for inclusion in the model was less than 0.05. In addition, baseline microbiology of P. aeruginosa orMRSA was included as a clinically important variable.Assumption of...
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Báo cáo y học: "Surgical and medical emergencies on board European aircraft: a retrospective study of 10189 cases"
... werealso obtained from the individual airlines. rpk is a measure of the volume of passengers carried by an airline; it is the sum of the products obtained by multiplying the number of revenuepassengers ... that by the year 2030, half of all aircraft passengerswill be over 50 years of age [1]. In addition to the continuousincrease in the average age of passengers, flight stress andchanges in the ... diversions, whether the incident occurred on acontinental or intercontinental flight, and the involvement of aphysician or medical professional (nurse or paramedic) in pro-viding therapy. The authors...
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Báo cáo y học: " A Dietary Supplement Containing Standardized Phaseolus vulgaris Extract Influences Body Composition of Overweight Men and Women"
... supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbo-hydrate-derived ... Examining intragroup analysis of the Control group by the paired t test, the following averages ± SEM were found at the beginning and end of the study respectively: in kilograms body weight ... changes in the Test group by the paired t test, the fol-lowing averages ± SEM were found at the beginning Int. J. Med. Sci. 2007, 4 49and end of the study respectively: in kilograms body weight...
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Báo cáo khoa học: Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression pot
... The Authors Journal compilation ª 2009 FEBSDNA synthesis evaluated by [3H]thymidineincorporation Cell proliferation was evaluated as the rate of DNA synthe-sis by [3H]methylthymidine incorporation ... replication.ResultsBetA-induced selective cytotoxicity in HBV-infected hepatocytesWe first examined the cytotoxicity of BetA in wild-type (WT) and HBV-infected hepatocytes. Different dosages of BetA were ... PCR. In vitro phosphorylation of CREB at Ser133Purified CREB was phosphorylated by the catalytic subunit of PKA (no. P2645; Sigma) by incubating 2.0 lm CREB in a reaction mixture containing 4.0...
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Báo cáo Y học: Early growth response-1 gene (Egr-1 ) promoter induction by ionizing radiation in U87 malignant glioma cells in vitro pot
... 2002converge in their activity on the phosphorylation of E lk-1,including the c ascade leading to the activation of stressactivated protein kinases (JNK/SAPK), the ras-activatedfactor/extracellularly ... 2002 of c-Jun (S73) was only marginal. By using a pan -c-Jun antibody, which recognizes c-Jun independently of itsphosphorylation status, a partial phosphorylation of the c-Jun protein, presumably ... can be induced by asingle dose of 4 Gy. The data presented indicate thatradiation induction of the Egr-1 promoter is at least in part mediated by protein factors secreted by U87 cells in response...
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Tài liệu Báo cáo Y học: The solution structure and activation of visual arrestin studied by small-angle X-ray scattering pot
... phosphorylation of the C-terminus of R* and binding by arrestin. Phosphorylation somewhatdecreases the ability of R* to signal transducin. Rapid shut-off of R* signalling is then accomplished by binding ... changes in the proteolytic digestionpattern that result from phosphopeptide binding [7] or by heparin binding [11], and changes in cysteine reactivitydue to phosphopeptide binding or the activating ... mediated by either the N-terminal or C-terminal domain to yield adimer that is even more elongated than the monomer. The dimer in solution may be contained in the crystalstructures of arrestin....
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Báo cáo Y học: Activation of transcription of the human presenilin 1 gene by 12-O-tetradecanoylphorbol 13-acetate pdf
... to increase by 2.5– tothreefold in the presence of TPA. Thus the increase in the level of PS1 mRNA observed by Northern blotting of totalcellular RNA results from an increase in the rate of initiation ... increases the rate of transcription initiation of the PS1 gene in SK-N-SH cellsTo determine whether the increase in the level of PS1mRNA results from the activation of the transcription of the gene ... offexperiments, indicating that the increased mRNA levelresults from an activation in the initiation of transcription of PS1. Consistently, TPA also increased the level of PS1 pro-tein. No activation of the...
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Báo cáo Y học: Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation docx
... built ahomology model of human PXR in order to identifyresidues that were likely to be involved in ligand binding.Since the initiation of this study the crystal structure of the human receptor ... hydrophilic side chain has been replaced by ahydrophobic one in the core of the ligand binding pocket. The Q285I mutant also shows decreased propensity for activation by rifampicin, which indicates ... for coactivator binding and thereby activation. Replacing the histidine with an alanine in the humanreceptor creates a void, which is surrounded by the hydrophobic side chains of Phe281, Met323,...
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Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc
... explained by the association of these proteins in acomplex. As in the preceding fractionations, eluted proteinswere analyzed by SDS/PAGE, followed by Coomassie bluestaining. At this stage of the ... S100A8/A9,accompanied by a majority of p67phox, p47phox and Rac.Analysis of the protein distribution in the two HTP pools by SDS/PAGE followed by Coomassie blue staining revealed adiscrete number of proteins, including ... traces of protein contaminant [15]. The identity of S100A8 was furtherascertained by amino-acid sequencing, using Edman degra-dation. As S100A9 has a blocked N-terminal amino acid,analysis of the...
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