... out the possibility of an autocrine, paracrine orendocrine mechanism of regulation in the ob ⁄ obmodel), and given that the majority of leptin receptorsexist in the arcuate nucleus of the hypothalamus, ... hypothalamus, the hypothesis that leptin controls bone formation via acentral mechanism was raised. The most convincingevidence supporting this hypothesis was the rescue of the bone mass phenotype of the ... Y5 and y6) thatvary in their binding profiles and in their distributionin the central nervous system and periphery. Y1, Y2 and Y5 are the best characterized NPY receptors, and the majority of...