... HO-1 and HO-2 expression in human cell linesWe initially analyzed the effects of hypoxia on theexpression of HO-1 and HO-2 in human cell lines of bone marrow origin, including KG1 myeloid cells, ... [3–5].Characteristically, human HO-1 contains no cysteineresidue [6], whereas HO-2 contains at least two copies of a potential heme-binding site, consisting of the cysteineand proline (CP motif) [7,8]. Importantly, ... of HO-2 mRNA and protein in fiveout of six human cell lines: Jurkat, YN-1, K562, HeLaand HepG2. In this context, Newby et al. [29] des-cribed decreased levels of HO-2 protein in placentasof...