... December2010)doi:10.1111/j.1742-4658.2010.07980.x The escalating prevalence of obesity is one of the most pressing healthconcerns of the modern era, yet existing medicines to combat this globalpandemic are disappointingly limited in terms ... molecules,including cyclins, cyclin-dependent kinases, their inhib-itors and the retinoblastoma protein (RB), as well asE2Fs.E2F and RB family members appear to participate in the regulation of cell-cycle ... of increased prolifera-tion or recruitment of preadipocytes [12], suggestingthat these cyclin-dependent kinase inhibitors areimportant in the regulation of adipocyte number. The S-phase kinase-associated...