Báo cáo khoa học: "THE DESIGN OF THE KERNEL ARCHITECTURE FOR THE EUROTRA* SOFTWARE" pptx
Báo cáo khoa học: Structural recognition of an optimized substrate for the ephrin family of receptor tyrosine kinases pot
... are subtle, the phosphotyrosine at the +2 plays an impor- tant role in reordering the structure of the region of the C-terminal lobe that interacts with these substrates. In the absence of the phosphate ... shows clear density for most of the substrate pep- tide, including main chain atoms for the )4 through to the +4 position, but partial or no density for...
Ngày tải lên: 16/03/2014, 02:20
Báo cáo khoa học: Identification of alternative promoter usage for the matrix Gla protein gene Evidence for differential expression during early development in Xenopus laevis doc
... primers used for PCR amplification. a + c for amplification of the larger IA transcript; b + c for amplification of the shorter IB transcript. (B) PCR amplification of the two specific transcripts and of the ... identifies for the first time, the presence of alternative promoter usage for the MGP gene and provides clear evidence for differential expression of th...
Ngày tải lên: 30/03/2014, 16:20
Báo cáo khoa học: "Automatic Induction of Finite State Transducers for Simple Phonological Rules" pptx
... corresponds to the end of an input sample. The output symbols are placed as near the root of the tree as possible while avoiding conflicts in the output of a given arc. An example of the result of this ... have the same behavior if they agree each of the following: • the index i of the output symbol corresponding to the input symbol (determined from th...
Ngày tải lên: 08/03/2014, 07:20
Tài liệu Báo cáo khoa học: Molecular defect of isovaleryl-CoA dehydrogenase in the skunk mutant of silkworm, Bombyx mori ppt
... 4452–4463 ª 2010 The Authors Journal compilation ª 2010 FEBS 4453 the a-hydrogen of the substrate, and the other is G374, which forms the binding pocket for the branched-chain acyl moiety of substrate ... the sku phenotype. Because G376V was a novel mutation in IVD, the effect of the mutation was further investi- gated by molecular modelling. Together with the prev...
Ngày tải lên: 18/02/2014, 04:20
Tài liệu Báo cáo khoa học: Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients pdf
... CCL13 enhances the proliferation of FLS [13,47]. Our group reported that the proliferation of FLS by MCP- 4 ⁄ CCL13 is dependent on activation of the extracellu- lar regulated kinase MAPK. The activation of ... protective against the development of RA [61]. The gene copy number variations of CCL3-like 1 (CCL3L1), a nonallelic isoform of CCL3 encoded by different gene...
Ngày tải lên: 18/02/2014, 18:20
Tài liệu Báo cáo khoa học: Influence of modulated structural dynamics on the kinetics of a-chymotrypsin catalysis Insights through chemical glycosylation, molecular dynamics and domain motion analysis pptx
... observed for the glycosylated a-CT conjugates as these residues are directly involved in the hydrogen transfer steps of cata- lysis. A decrease in the dynamics of these two loops could reinforce the ... (nucleophilicity) for the in silico creation of the various glycoconjugates was determined by calculating the electrostatic potentials (EP) for the N e of the l...
Ngày tải lên: 19/02/2014, 05:20
Tài liệu Báo cáo khoa học: Electrostatic role of aromatic ring stacking in the pH-sensitive modulation of a chymotrypsin-type serine protease, Achromobacter protease I pdf
... 3B). The pK 2 increased as the size of the residue at position 169 increased. The effect of the size of the residue at position 169 may be related to the solvent accessibility of the side-chain of His210 ... nucleophilicity of the Ser194 hydroxyl oxygen. Accord- ingly, the Asp113–His57 diad is primarily important for the expression of the nucleophilicit...
Ngày tải lên: 21/02/2014, 03:20
Báo cáo khoa học: Kinetic characterization of methionine c-lyases from the enteric protozoan parasite Entamoeba histolytica against physiological substrates and trifluoromethionine, a promising lead compound against amoebiasis ppt
... that for Met and Cys, whereas the k cat of EhMGL2 for TFM was 16–22-fold higher than that for these physiological substrates. The K m of EhMGLs for TFM was 52–470- fold lower than that of the ... molecular ratio of 1 : 1000, and further tested for the Met-degrading activity on the basis of the detection of a-keto acid after the addi- tion of 2 mm Met (Fig...
Ngày tải lên: 07/03/2014, 05:20
Báo cáo khoa học: Versatile regulation of multisite protein phosphorylation by the order of phosphate processing and protein–protein interactions pptx
... interactions. To be specific, the dissociation constants of the var- ious phosphorylation states of the target for the kinase were all set equal to L 0 , except for the value L N for the fully phosphorylated ... Schematic representation of a phosphorylation–dephosphorylation cycle. (B) Mathematical model for a sequential mechanism of multiple phos- phorylation based...
Ngày tải lên: 07/03/2014, 10:20
Báo cáo khoa học: Biochemical characterization of recombinant dihydroorotate dehydrogenase from the opportunistic pathogenic yeast Candida albicans pot
... PAGE (Fig. 3) showed that the purified enzymes were of the expected molecular mass of 48 kDa for the full-length enzyme and 42 kDa for the truncated enzyme. The yield of recombinant proteins purified ... 30 °C, the oxidation of the substrate DHO with the quinone cosub- strate was coupled to the reduction of the chromogen 2,6-di- chloroindophenol. The K m of...
Ngày tải lên: 07/03/2014, 12:20