Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx
Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx
... modeled the complex by firstplacing C5 in the context of the gp120 core structure determined by X-ray crystallography [7]. The first threeresidues of the C5 domain used in the present study(amino ... in the gp120 X-ray structure; thus, the C5 domain can be overlaid with the Cterminus of the gp120 X-ray structure (the RMSD of the NMR VKI backbone to the X-ray VKI backbone is0.4 A˚). The ... that HIV C5 directly interacts with the HIV gp41 ectodomain in the presence of cosolvent, suggesting that the C5 structure presented herein is physiologically relevant. The HIV gp120 C5 structure...
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Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc
... 2001geometry, the set of solutions reflects any uncertainty in the calibration as well as alternative fits to the set of distances. The main advantages of the procedure are simple: the details of the ... mobility with respect to the rest of the structure. Further studies of the receptorbound forms of the chimera and other related ligands will benecessary to define the nature of the interactions leading ... found.Several of these were identified in previous studies of EGF,and the backbone fold of the chimera is clearly similar tothose of the EGF structures. The presence of a backbonehydrogen bond from the...
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Báo cáo Y học: Solution structure of the Alzheimer amyloid b-peptide (1–42) in an apolar microenvironment Similarity with a virus fusion domain potx
... 28–38, connected by a regulartype I b-turn. The surprising similarity of this structure, aswell as the sequence of the C-terminal moiety, with those of the fusion domain of influenza hemagglutinin ... is the finding that the sequences of the C-terminal part of Ab-(1–42) and that of HA_fd share indeed a high similarity (Fig. 6C) dictatedessentially by the presence of similarly spaced glycineresidues, ... different in the case of Ab,but it is fair to say that the similarity with the fusion domain of a virus is strongly suggestive of membrane disruption. The recent observation of a strong synergism...
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Báo cáo Y học: NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol Comparison with the Vpr N-terminal (1–51) and C-terminal (52–96) domains pot
... significantly mod-ifying the secondary structural elements of the protein.One consequence of the presence of TFE on the structure of Vpr is the tertiary structure may open up. However, the NMR solution ... beenclearly demonstrated by the loss of activity of Vprfollowing certain point mutations [16,38,39]. This is one of the main reasons why the aim of this study was todetermine the solution structure of ... Tyr50 cH Thr552.6H Tyr50 a1Gly563.5H Tyr50 a1Gly562.6H Tyr50 a2Gly563.5H Tyr50 a2Gly562.6H Tyr50 a Ala593.5H Tyr50 a Ala592.6H Tyr50 b Ala593.5H Tyr50 b Ala59b1Tyr50 a1Gly56b2Tyr50...
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Báo cáo Y học: Solution structure of a hydrophobic analogue of the winter flounder antifreeze protein doc
... HNresonance of Ser4 is the most low-field shifted amide (Fig. 2). Solution structure of VVVV2KE The solution structure of VVVV2KE, represented by the ensemble of 20 energy-minimized DYANA conformers,consists ... structures. Aswith the NMR structure of VVVV2KE, the N-terminal cap structure of TTTT includes a hydrogen bond between the side chain carboxyl group of Asp1 and the backbone amide of Ser4. The ... NH2and the carbonyl oxygen of residue 35 may be significantlypopulated at low temperatures, in agreement with the crystal structure of TTTT [8]. In contrast to the crystal structure of TTTT,...
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Tài liệu Báo cáo khoa học: Solution structure of the matrix attachment region-binding domain of chicken MeCP2 ppt
... The MBD of MBD1 contacts the methylgroups of a methylated CpG through a hydrophobic patchformed by the side chains of five residues, V20, R22, Y3 4,R44, and S45 [19].Although the solution structure ... one-turn helix on the other face. It is thoughtthat the two inner strands of the b-sheet lie within the majorgroove of the DNA and that a hydrophobic pocket formedby the side chains of Y1 23 and I125 ... report the solution structure of MAR-BDas determined by multidimensional heteronuclear NMRspectroscopy. The global fold of this domain is very simi-lar to that of rat MeCP2 MBD and MBD1 MBD (the methyl-CpG-binding...
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Báo cáo khoa học: Solution structure of the catalytic domain of RICH protein from goldfish pot
... similarity of the structures. The lowest-energy structure from the RICH NMR ensemble is used for the overlay. (D) The surface of the RICH catalytic domain shows several negatively charged patches of ... Secondary structure and the two catalytic motifs (*) areshown. (B) Representation of flexibility in the solution structure of the RICH catalytic domain. The width of the sausage is reverselyproportional ... close to itsFig. 2. Structure of goldfish RICH catalytic domain. (A) Stereo view of the backbone superposition of 10 lowest energy structures of the RICH catalytic domain. The superposition was...
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Báo cáo khoa học: Solution structure of the active-centre mutant I14A of the histidinecontaining phosphocarrier protein from Staphylococcus carnosus ppt
... back onto the core of the protein thereby allowing the side chain of Leu86 to partly fill the hole created by the removal of Ile14. Due to these changes other alterations areinduced in the HPr(I14A) ... displays a kink towards the interior of the protein. The space that in the wild-typemolecule is occupied by the large hydrophobic side chain of Fig. 3. Structure ensemble of HPr(I14A). The average ... average structure of the 10 lowest- energy structures out of 300 calculated withCNSis shown.TheradiusofthesplinereflectstheRMSDvaluesoftheCaatompositions. Th e s cale bar indicates a length of...
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Báo cáo Y học: Crystal structure of the catalytic domain of a human thioredoxin-like protein pdf
... little directeffect on the activity of the enzyme. The function of thisunique C-terminal domain remains unknown.Overall structure Crystals of the catalytic domain of hTRXL (hTRXL-N)were obtained ... pairs of hydrogen bonds are formed in the active site of hTRXL-N (Fig. 4), accounting for the compactness and stability of the active site. The H-bondlength between the carbonyl oxygen of Cys34 ... the Cys73–Cys73 disulfide bond [23]. The substitution of thesehydrogen bond forming residues in hTRXL-N may accountfor the formation of a monomer, instead of a dimer in the case of TRX. Furthermore,...
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Báo cáo khoa học: Solution structure of the bb¢ domains of human protein disulfide isomerase docx
... in the relativeorientations of the a and b domains. In one struc-ture, the catalytic cysteines face each other; in the other, the catalytic residues of the a domain faceaway from the a¢ domain. ... Superimposition of the solution structure of the human PDI-b¢ (blue) with the crystal structure of yeast PDI-b¢ (red, Protein Data Bankentry code 2B5E). (C) Superimposition of the solution structure of human ... He1(Phe209)⁄ HN(Leu236).Analysis of RDCs for the two domains yielded the same degree of alignment and rhombicity, which fur-ther confirms the rigid structure of the bb¢ domain frag-ment (Fig. S2)....
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngBáo cáo quy trình mua hàng CT CP Công Nghệ NPVchuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu tổ hợp chất chỉ điểm sinh học vWF, VCAM 1, MCP 1, d dimer trong chẩn đoán và tiên lượng nhồi máu não cấpNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longPhát hiện xâm nhập dựa trên thuật toán k meansNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu tổng hợp các oxit hỗn hợp kích thƣớc nanomet ce 0 75 zr0 25o2 , ce 0 5 zr0 5o2 và khảo sát hoạt tính quang xúc tác của chúngThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roTổ chức và hoạt động của Phòng Tư pháp từ thực tiễn tỉnh Phú Thọ (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Trách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)TÁI CHẾ NHỰA VÀ QUẢN LÝ CHẤT THẢI Ở HOA KỲ