Báo cáo Y học: Formation of aberrant phosphotau fibrillar polymers in neural cultured cells doc

... hyperphosphorylated form [5–8] assembles into fibrillar polymers. The mechanism for that aberrant tau assembly has been widely analyzed by several groups, i ndicating that sulfated glycosaminoglycans ... cells is in hyperphosphorylated form Treatment of SH-SY 5Y human neuroblastoma cells with okadaic acid (OA), a phosphatase inh ibitor, results in the hyperphosphorylation of...

Ngày tải lên: 08/03/2014, 16:20

... class of enzymes catalyzes the formation of hydroxy, epoxy, and acetylenic groups, respectively, within a fatty acid backbone [13,14]. Furthermore the reaction takes place while the acyl moiety is ... which show that the growing family of special acyl-lipid-desaturases catalyzes the formation of a wide array of functional groups within unusual fatty acids predominantly found in...

Ngày tải lên: 08/03/2014, 16:20

... conditions remains to be deter- mined. The mechanism by which naringin and hesperi- din increase the thermogenic effect of p-synephrine may involve enhancing the expression of adiponectin which ... particularly in caffeine-sensitive individuals [39]. The absence of changes in blood pressure, rest- ing heart-rate and self-ratings in the four treatment groups involving p-synep...

Ngày tải lên: 25/10/2012, 11:04

... indicate the difficulty in amplifying the sequences in these re- gions. In our study, we attempted to amplify each ex- tremity, but failed. Interestingly, phylogenetic analysis based on the NS1 ... etiology of hepatitis remains obscure in 3-10% of cases in Europe [5] and the United States [6] and up to 30% of cases in Asia [7, 8]. Particularly, the cause of fulminant...

Ngày tải lên: 26/10/2012, 10:03

... kidney and heart, PPARγ is most abundant in adipocytes, intestinal cells and macrophages and PPARδ is expressed in many tissues [2-4]. Each subgroup is activated by a certain variety of fatty ... The +294T/C polymorphism in exon 4 of the PPAR δ gene was initially described by Skogsberg et al [8]. It was shown that the polymorphism influenced binding of Sp-1 resulting in...

Ngày tải lên: 31/10/2012, 17:03

... characteristic property of the interacting surfaces of homodimers [19]. Furthermore the interacting surface of proteases is characterized by distin- guishing marks, mainly serine and histidine active site signatures, ... N-terminal domain, which binds ATP. This protein can bind and release peptides (in the Ct domain) in a cycle driven by nucleotide hydrolysis and exchange (in the Nt...

Ngày tải lên: 21/02/2014, 15:20

... single cells after u sually 5 days and reach sizes of  5 mm; they contain proliferating cells and their interior is surrounded by an almost complete single-cellular layer of epithelial-like cells, pinacocytes; ... (2–5)A synthesizing activity in S. domuncula. Despite the initially high (2–5)A synthesizing activity in tissue of G. cydonium (aquarium animals), the incubation wi...

Ngày tải lên: 21/02/2014, 15:20

... decrease in the activity for the 11b-hydroxylase, CYP11B1. Intriguingly, however, the 11b-hydroxylase activity of the aldosterone synthase CYP11B2 was basically unaffected whereas the 18-hydroxy- lation ... major mineralocorticoid by means of an 11b-hydroxylation and an 18-hydroxylation/oxidation of 11-deoxycorticosterone. Thus, the proteins of the CYP11B subfamily catalysing the la...

Ngày tải lên: 22/02/2014, 07:20

... accessibility of accessory sites in res, gd102NLS employs two recombination pathways in eukaryotic cells that can be distinguished by the resulting products. In order to compare the activities of Cre ... probably randomly into the host genome (data not shown). We first analyzed recombination in cell line TRE2/3 which contains a single copy of the vector. The analysis was perfor...

Ngày tải lên: 22/02/2014, 07:20

... prolongation in the answering and processing times of emergency calls in Helsinki, the capital of Finland [5]. EMCC organization and EMD in Finland - before and now There used to be 45 municipality-based ... the structure of emergency dispatching. * Correspondence: veronica.lindstrom@ki.se 1 Karolinska Institutet, Department of Clinical Science and Education and Section of Eme...

Ngày tải lên: 25/10/2012, 10:02