Báo cáo Y học: What does it mean to be natively unfolded? pptx
Báo cáo Y học: What does it mean to be natively unfolded? pptx
... ARTICLE What does it mean to be natively unfolded? Vladimir N. Uversky 1 Institute for Biological Instrumentation, Russian Academy of Sciences, Pushchino, Moscow, Russia; 2 Department of Chemistry ... ÔboundaryÕ mean hydrophobicity value, <H> b , below which a polypeptide chain with a given mean net charge <R> will be most probably unfolded: hHi b hRi1X151...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo y học: "Using Medical Emergency Teams to detect preventable adverse events"
... physician (intensiv- ist during the day and a critical care resident at night), a critical care nurse, and a critical care-trained respiratory therapist. The MET can be activated by any hospital ... event detection system at little additional cost. Introduction Medical Emergency Teams (METs), alternatively known as Rapid Response Teams, have recently been implemented in many hospitals world...
Ngày tải lên: 25/10/2012, 10:06
Báo cáo y học: "Current Status of Methods to Assess Cancer Drug Resistance"
... mainly cytostati- cally compared with classical cytotoxic drugs require special timing of scans [68]. International guidelines for PET tests are therefore necessary to guarantee the quality and ... Chemosensitivity Vol 1, In Vitro Assays. To- towa, New Jersey: Humana Press; 2005. 31. Kern DH, Weisenthal LM: Highly specific prediction of antineoplastic drug resistance with an in vitro...
Ngày tải lên: 25/10/2012, 11:10
Báo cáo y học: "Serum cystatin C levels to predict serum concentration of digoxin in Japanese patients
... Introduction Cystatin C (Cys-C) is a non-glycosylated cationic protein of 13.3 kDa, belonging to the cystatin superfamily of cysteine protease inhibitors [1, 2]. Cys-C is produced by all nucleated ... visiting Kobe University Hospital from January to July in 2002. These patients were maintained in a stable condition by the once daily oral dosing of digoxin at 0.17 ± 0.06 (0.06-0.2...
Ngày tải lên: 31/10/2012, 17:08
Tài liệu Báo cáo Y học: Studies into factors contributing to substrate specificity of membrane-bound 3-ketoacyl-CoA synthases pot
... specificity similar to that of A. thaliana FAE1 KCS. However, a K92R substitution in thischimeric enzyme changed the specificityto that of the B. napus enzyme without loss of catalytic activity. Thus, ... empty vector was grown under galactose induction conditions. The VLCFA content of yeast carrying the empty vector was principally limited to 26:0 with little or no C20, C22 or C24 fatty ac...
Ngày tải lên: 21/02/2014, 15:20
Báo cáo Y học: Solution structure of the HIV gp120 C5 Domain pptx
... Recently, the structure of HIV gp120 in complex with regions of the CD4 receptor and a monoclonal antibody that blocks gp120 binding to the chemokine receptor has been determined by X-ray crystallography ... which are largely missing in the crystal structure but would be expected to be proximal to one another, are involved in the interaction with gp41 [8,9]. Furthermore, it has re...
Ngày tải lên: 08/03/2014, 16:20
Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt
... factor in the regulation of WD promoter activity. Comparison of WD promoter activity in Ku-deficient Xrs-5 cells to the activity in CHO cells To verify that Ku-80 is an essential regulatory factor ... intensity of WD cDNA/intensity of competitor and then divided by intensity of amplified actin cDNA. PC, the result of competitive RT-PCR using mRNA isolated from nontransfected HepG2 cells as...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Regulation of peptide-chain elongation in mammalian cells pptx
... ADP-ribosylated by diphtheria toxin [25]. ADP-ribosylation inhibits the activity of eEF2. Phosphorylation of eEF2 inhibits its activity, in translo- cation and in poly(U)-directed polyphenylalanine synthesis [26,27], ... way to enhance its intracellular activity than rendering it independ- entofCa 2+ ions. This is because intracellular Ca 2+ ion concentrations fluctuate on a beat -to- beat...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx
... differen- tially dephosphorylated by CaNa and CaNb in vivo. The differences in phosphatase activity and sensitivity to FKBP12/FK506 or CyPA/CsA inhibition between CaNa and CaNb that we observed may be due to ... and substrate may influence the degree of inhibition of CaN phosphatase activity by FKBP12/FK506 and CyPA/CsA. The differences in phosphatase activity and sensitivity to FKBP12...
Ngày tải lên: 24/03/2014, 03:21
Báo cáo Y học: Mistletoe viscotoxins increase natural killer cell-mediated cytotoxicity pptx
... of bystander cells. (A) Enhancement of NK cytotoxicity cannot be reproduced by a VTA2 pulse of effector or target cells before the lysis assay. The effector cells or target cells were separately ... highly purified viscotoxins alone enhance the efficiency of tumor cell lysis by NK cells in the absence of any direct cytotoxicity to the target. Although the mode of viscotoxin action has not bee...
Ngày tải lên: 31/03/2014, 15:20