Báo cáo khoa học: NMR investigations of subunit c of the ATP synthase from Propionigenium modestum in chloroform/methanol/water (4 : 4 : 1) pot
Báo cáo khoa học: NMR investigations of subunit c of the ATP synthase from Propionigenium modestum in chloroform/methanol/water (4 : 4 : 1) pot
... isdue to the interaction of the monomer with the artificialenvironment lacking the stabilizing protein/protein contactswithin the ring. The undecameric c ring of the ATP synthase from Ilyobacter ... ch loroform/meth anol/water (4 : 4 : 1) [23], amino-acidsequence of P. modestum subunit c with the helix locations in (b) SDS micelles [ 24] , and (b¢) in chloroform/methanol/water (4 : 4 : 1 ). ... the structure of subunit c from P. modestum in chloroform/methanol/water (4 : 4 : 1). Under these conditions, the protein f olds significantly dif-ferent from subunit c in dodecylsulfate micelles...
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Báo cáo khoa học: NMR solution structure and function of the C-terminal domain of eukaryotic class 1 polypeptide chain release factor pdf
... obtained from 3D experiments correlating the amide NH with the C signal of the preceding amino acid, correlating the amide HN and the Ca signals, correlating the amide HN and the Ca signal of the ... detectable.Effect of mutations in the minidomain on stopcodon specificitySuperposition of the NMR structure of the human C- domain on the full-length crystal structure of eRF1reveals that the minidomain ... atoms of the C- domain core residues. The minidomain is shown in red. The topcodon recognition NIKS sequence in the N-domain and the strictlyconserved GGQ triplet in the M-domain involved in peptidyl-tRNAhydrolysis...
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Báo cáo khoa học: NMR and molecular dynamics studies of an autoimmune myelin basic protein peptide and its antagonist Structural implications for the MHC II (I-Au)–peptide complex from docking calculations ppt
... eycharacteristic of the structure of the native epitope in Me2SO is the presence of a large number of electrostaticinteractions, especially in the central region of the peptide. The side chain ... I-Aubecause o f occupation of the P1 pocket.Recent thermodynamic a nd kinetic studies of the b inding of TCRs to peptide–MHC ligands suggested that the lowaffinity of the TCR–peptide–MHC complexis ... esign and synthesis of a p otent c yclic ana-logue of the myelin basic p rotein epitope MBP72-8 5: importance of the Ala81 carboxyl group and of a cyclic conformation forinduction of experimental...
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Báo cáo khoa học: A pathway through interferon-c is the main pathway for induction of nitric oxide upon stimulation with bacterial lipopolysaccharide in mouse peritoneal cells pot
... anti-IFN -c Ig, of LPS-induced NOproduction in murine PEC but not in the RAW2 64. 7murine macrophage cell lineCells of murine PEC and of the RAW2 64. 7 murinemacrophage cell line were cultured ... of cofactors such ascytokines. In the case of region 2 activation, stimulation of the macrophages with interferon -c (IFN -c) , but not withLPS, was found to be effective for inducing the binding ... nonadherent cells were required in the PEC culture. Considering these results overall, the indi-rect pathway, through the production of intermediates (suchas IFN -c- inducing cytokines and IFN -c) by the...
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Tài liệu Báo cáo khoa học: Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1 pptx
... finally examined the effect of deletion of the components of the PDZ binding motif on the signal-ing properties of the receptor in Ca2+imagingexperiments. Truncation of the receptor from the final ... of PDZ binding motifs, occurring at the C- terminus of the interacting proteins [16]. We scanned the human olfactory receptor repertoire for putativebinding motifs and discovered them in the extreme C- termini ... resulting in the activation of adenylyl cyclase type III [2] via the olfactory G protein Gaolf[3]. cAMP then binds to acyclic nucleotide-gated channel [4 7], allowing it toconduct cations such...
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Báo cáo khoa học: An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata pot
... and [1- 14 C] acetyl-CoA (47 mCiÆmmol)1) were purchased from MoravekBiochemicals (Brea, CA, USA). 4- Coumaroyl-CoA,cinnamoyl-CoA, 4- methoxycinnamoyl-CoA, benzoyl-CoA,phenylacetyl-CoA and N-methylanthraniloyl-CoA ... substrate-binding pocket (the so-called ‘coumaroyl-bindingpocket’ [3]) at the active site of the enzyme, and guides the course of the Claisen-type aromatic ring formationreaction of the enzyme-bound ... anthranilic acid is a key intermediate in the biosynthesis of acridone alkaloids, which occur in greatest abundance in plants from the Rutaceae family[8]. In fact, ACS from Ru. graveolens is the onlyknown...
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Báo cáo khoa học: "A Preference-first Language Processor Integrating the Unification Grammar and Markov Language Model for Speech Recognition-ApplicationS" potx
... ~:ntcnc¢ constilucnt obtained during the con~ of parsing is ulkcn as the Rsuh first-k rule: the sontcnc¢ constltmmt with ~hc highest probability among the first k c. o~s~ct¢d ¢rammadcal scnunac~ ... Construction principles: random mincit)le: at 1my ~ nmd~ly select It c~ adidatc conslJt ucnt to be constttlct~ probability selection l~rinciole: at any dmc the candi~llt¢ consdtucnt with ... noisy word hypotheses and significantly reducing the search space. In this way, not only can the features of the grammatical and statistical approaches be combined, but the effects of the two different...
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Báo cáo khóa học: Different associational and conformational behaviors between the second and third repeat fragments in the tau microtubule-binding domain pdf
... aggregation of which was induced by adding heparin. The aggregationkinetics was then derived from the time dependence of fluorescence intensity. As shown in Fig. 2A, the fluorescenceintensity of R3 reached ... flexible to change theirstructures, depending on the hydrophobic and hydrophilicbalance of the solvent. On the other hand, the calculation from the CD ellipticity [17] indicated a meaningful differ-ence ... aJASCO FP-6500 instrument using a 2-mm quartz cell, in which the temperature was maintained at 37 °Cbyacirculating water bath. The kinetics of MBD aggregationwas analyzed by recording the time-dependent...
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Tài liệu Báo cáo khoa học: NMR structural characterization of HIV-1 virus protein U cytoplasmic domain in the presence of dodecylphosphatidylcholine micelles doc
... studied activities of VpU is the induc-tion of CD4 degradation in the endoplasmatic reticu-lum of infected CD4+cells. Only the cytoplasmicdomain of VpU, together with any membrane anchor,is ... concentration of DPC (1.5 mm in H2O). The initial addition of 5 mm DPC caused the most pro-nounced change in the CD spectrum, whereas increasing the detergent concentration further enhanced the ... preliminaryprotein structures [79]. radar runs in an iterative manner. The input of the first cycle consisted of the 3D NOESYdata, the amino acid sequence of VpUcyt and the chemicalshift list reflecting the...
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Tài liệu Báo cáo khoa học: Helix mobility and recognition function of the rat thyroid transcription factor 1 homeodomain – hints from 15N-NMR relaxation studies pdf
... the amide vector dynamics of this residue indicate localmotions occurring essentially over the nanosecondtimescale. The lack of fast internal motions reflects the crucial role of Gln50, which ... Leu26, the red colorindicates the coupling of low-frequency and high-frequency dynam-ics. With the exception of His52, all the mentioned residues arelocated in the hydrophobic core of the molecule ... wide range of correlation times, s. Most of the experimental points accumulate rather close to the upper intercept of the theoretical curve and the fitting(solid) line, where the motion of a unique15N–1H...
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