Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc
... of the hyaluronan synthase from Strepto-coccus pyogenes. J. Biol. Chem. 276, 2037–2046.Ó FEBS 2002 Inhibition of HA synthesis in Streptococcus by MU (Eur. J. Biochem. 269) 5075 Inhibition of ... n-dodecyl-b-D-maltoside;GlcNAc, N-acetylglucosamine; GlcUA, glucuronic acid; HA, hyaluronan (hyaluronic acid); HABP, hyaluronan binding protein;HAS (Has), hyaluronan synthase; MU, 4-methylumbelliferone; spHAS, S. pyogenes ... HA releasedinto the culture medium was measured by the sandwichbinding protein assay using hyaluronan binding protein(HABP) according to the manufacture’s instructions for thehyaluronic acid...
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt
... andultimately abolished, the increase in c-myc gene expressionelicited by PMA in serum-free cells. These results suggestthat inhibition of MEK/ERK signaling by NAMI-A mayhave an important role in modulating ... belying upstream of ERK1/2.Recent observations indicate that activation of Raf by PMA may trigger the same signaling pathway as oncogenicRaf, or Raf activation by Ras in combination with tyrosinephosphorylation ... to a scintillation vialcontaining 3.5 mL of INSTA-GEL scintillation fluid (Pack-ard instrument Co., Meriden, CT, USA), and radioactivitywas determined by liquid scintillation counting using aWallac...
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot
... wasreduced by 60% in the presence of 500 lMCl-tetracyclineand by 95% in t he presence of 500 lMerythromycin andstreptomycin (Fig. 2B,C). Tetracycline at 500 lMinhibitedsplicing by only 1 0% ... splicing inhibition by tetracycline is n egligible (Fig. 2). The sixfold stron gersplicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by thesubstitution, ... splicing apparatus. The inhibitoryeffect of erythromycin and Cl-tetracycline were not allevi-ated by Mg2+(Fig. 3).Kinetic analyses using increasing concentrations of erythromycin, Cl-tetracycline...
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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot
... processes including: activation of apoptosis in Jurkat T-cells [5], inhibition of plateletaggregation [6,7] and inhibition of in ammatory cytokineproduction in macrophages [8]. Curcumin has also ... activity of a number of key enzymessuch as cyclooxygenase [9], protein kinase C [10], proteintyrosine kinases [11] and a Ca2þ-dependent endonuclease[12]. Many of these processes/enzymes are ... Biochem. 268) 6327 Inhibition of the SERCA Ca21pumps by curcuminCurcumin putatively stabilizes the interaction between the nucleotide-binding andphosphorylation domains in the absence of ATPJonathan...
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Báo cáo Y học: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition ppt
... Auerswald, E.A. (1995) Temporary inhibition of papain by hairpin loop mutants of chicken cystatin. Distortedbinding of the loops results in cleavage of the Gly(9)-Ala10 bond.FEBS Lett. 361, ... a serine peptidase characterized by oligopeptidaseactivity. It is grouped in family S9A in clan SC [1]. Enzymesbelonging to clan SC are distinct from trypsin-type andsubtilisin-type serine ... dephosphorylation of InsP5to Ins(1,4,5)P3 by multiple inositol polyphosphatase[42]. This enzyme was reported to have increased activity in the PEP knock-out mutants of Dictyostelium [39]. NeitherIns(1,4,5)P3,...
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Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot
... organisms. In all systems investigated so far,mannosamine was able to inhibit GPtdIns biosynthesis. In T. brucei, mannosamine inhibits the incorporation of ethanolamine into GPtdIns protein by being incorporatedinto ... study glycosylphosphatidylinositol (GPtdIns)biosynthesis and GPtdIns protein anchoring in protozoaland mammalian systems. The effects of these analogues onGPtdIns biosynthesis and GPtdIns-protein ... nornonmannosylated intermediates accumulated in the pre-sence of mannosamine. The absence of new mannosamine-containing GPtdIns and the inhibition of incorporation of tritiated glucosamine into GPtdIns...
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Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... permeability studiesThe effect of 2-APB on membrane permeability wasmonitored by assessing the quenching of calcein dye trapped in egg phosphatidylcholine liposomes by Co2+, as described by Longland ... inhibition of SERCA (Eur. J. Biochem. 269) 3687 Inhibition of SERCA Ca2+pumps by 2-aminoethoxydiphenyl borate(2-APB)2-APB reduces both Ca2+binding and phosphoryl transfer from ATP, by interferingwith ... affinity forCa2+binding to the ATPase by more than 20-fold, andalso inhibits phosphoryl transfer from ATP (by 35%),without inhibiting nucleotide binding. Activity studiesperformed using mutant...
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Báo cáo y học: " Predictors of hepatic steatosis in HBeAg-negative chronic hepatitis B patients and their diagnostic values in hepatic fibrosis"
... with clinically and pathologically proven steatosis and 98 patients without steatosis were recruited into this study. The levels of fasting blood glucose (FBG), fasting insulin (FINS), triglyceride ... levels of serum alanine aminotransferase (ALT). The higher prevalence of hepatic steatosis in Hispanics was mainly due to the higher prevalence of obesity and insulin resistance in this ethnic ... were measured by en-zyme-linked immunosorbent assay (Livzon Group Reagent Factory, Guangdong, China). HBV DNA The HBV DNA level was determined by quan-titative polymerase chain reaction (qPCR)...
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Báo cáo y học: "Management of HBV Infection in Liver Transplantation Patients"
... contributing to the efficacy of combination LAM and HBIG remain poorly defined. Postulated mechanisms include the synergy of: 1) LAM reducing HBV replication and altering synthesis of HBsAg necessary ... finding of circulating HBV DNA by PCR in 2 of 11 receiving HBIG and 5 of 10 receiving LAM suggests that reinfection would be likely in additional patients with longer observation. Discontinuation of ... overcome by using a fixed dose of 10,000 IU once monthly [10]. However, monitoring of serum anti-HBs trough levels to define variability in immunoglobulin catabolism permits individualized dosing...
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Tài liệu Báo cáo khoa học: Interruption of triacylglycerol synthesis in the endoplasmic reticulum is the initiating event for saturated fatty acid-induced lipotoxicity in liver cells pdf
... remark-ably different effects. Exposure of a variety of celltypes, including hepatocytes, to long-chain saturatedfatty acids (SFAs) led to increased expression of proin-flammatory cytokines, inhibition ... of phosphatidylcholine ⁄ phosphatidylserine bilayers.Biophys J 66, 382–393.31 Mori T, Takai Y, Yu B, Takahashi J, Nishizuka Y &Fujikura T (1982) Specificity of the fatty acyl moieties of ... ability of the cells to accumulate triacylglycerols. Our datasuggest that interruption of triacylglycerol synthesis in the endoplasmic retic-ulum, apparently because of the formation of a pool of...
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