Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
Báo cáo khoa học: a-Fetoprotein positively regulates cytochrome c-mediated caspase activation and apoptosome complex formation docx
... AFPstimulates formation of the Apaf-1 apoptosome complex, enhances recruitment and activation of procaspase 3 in the complex, and stimulates release of active caspase 3 and 9from the apoptosome. ... thecomplexes.Fig. 7. AFP positively regulates formation of Apaf-1 apoptosome in cell-free extracts and promotes caspase activation and release of caspase 3 and 9from the complex. Aliquots (1 mL) ... Materials and methods.Ó FEBS 2003 AFP amplifies cytochrome c-mediated caspase activation (Eur. J. Biochem. 270) 4391AFP synergistically enhances cyt -c-mediated processing and activation of procaspases...
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Tài liệu Báo cáo khoa học: Collagen I regulates matrix metalloproteinase-2 activation in osteosarcoma cells independent of S100A4 pdf
... indecreased proMMP-2 activation and reducedMT1-MMP expressionA decrease in the total amount of MMP-2 (72, 64 and 62 kDa bands), as well as in the active MMP-2 forms(64 and 62 kDa bands), was observed ... expression pattern and activation mechanisms. The best-described activation mechanism for MMP-2 is the two-step cell-surface activation in which proMMP-2 is activated in a trimo-lecular complex including ... autoactivation of proMMP-2 [15]; APMA-induced autoactivation of proMMP-3 and N-terminally truncated proMMP-3 [15,40]; and APMA-induced autoactivation of proMMP-1 and proMMP-8 [16,17]. At the cellular level,...
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Tài liệu Báo cáo khoa học: Oxygen tension regulates the expression of a group of procollagen hydroxylases docx
... hypoxia(0.5% oxygen) and deferoxamine (100 lmolÆL)1) clearlyinduced P4ha1 (four- and sevenfold) and P4ha2 mRNA(seven- and fourfold) and to a lesser extent also PDI mRNA(two- and 1.5-fold), whilst ... chelation and cobalt with those reported by Tanaka and coworkersfor cultured astrocytes [15]. Our findings thus on the onehand fully support these previous findings and on the otherhand extend ... P4ha-subunits [aI (P4ha1) and aII (P4ha2)] and of two lysyl-hydroxylases (PLOD1 and PLOD2). These effects of hyp-oxia were mimicked by the iron-chelator deferoxamine(100 lM) and by cobaltous chloride...
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Báo cáo khoa học: Human anionic trypsinogen Properties of autocatalytic activation and degradation and implications in pancreatic diseases potx
... lMCa2+(A) and pH 5.0 (B and C). Autoactivationexperiments were carried out asin Fig. 9A (A) and 10(B and C). Samples(2 lMtotal zymogen in 100 lL) were trichloroacetic acid-precipitated and analyzed ... trypsinogenProperties of autocatalytic activation and degradation and implicationsin pancreatic diseasesZolta´n Kukor, Miklo´sTo´th* and Miklo´s Sahin-To´thDepartment of Molecular and Cell Biology, Goldman ... seemed to determine the rate of autoactivation and the final levels of trypsin generated. Consequently, anFig. 11. Autoactivation of physiological (67% Hu1–33% Hu2) and pathological (33% Hu1–67% Hu2)...
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Báo cáo khoa học: "High-precision Identification of Discourse New and Unique Noun Phrases" docx
... the literature.R. Vieira and M. Poesio use hand-crafted heuris-tics, encoding syntactic information. For exam-ple, the noun phrase “the inequities of the currentland-ownership system” is classified ... discourse and the hearer givenness.Theresulting taxonomy is summarised below:brand new NPs introduce entities which areboth discourse and hearer new (“a bus”), sub-class of them, brand new ... types of appositions areidentified: with and without commas (“RupertMurdoch, News Corp.’s chairman and chief ex-ecutive officer,” and “News Corp.’s chairman and chief executive officer Rupert Murdoch”).In...
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Tài liệu Báo cáo khoa học: Proteolytic processing regulates pathological accumulation in dentatorubral-pallidoluysian atrophy pdf
... (0.2 lm and 20 lm; Roche Diagnostics), pan caspase inhibitor Z-VAD-FMK (50 lm; Peptide Institute), caspase- 1 and -4 inhibitor Z-YVAD-FMK (50 lm; Bachem, Du¨ben-dorf, Switzerland), caspase- 2 ... tract was cleaved by caspase- 3 in vitro and in thehuman brain tissues [27], and that cleavage at the caspase- 6 site in huntingtin was essential for theHD-related behavioural and neuropathological ... cleavage sites for caspase werecontained in huntingtin, ATN1, ataxin-3 and androgenreceptor, and showed that the cleavage of all four pro-teins could be inhibited by treatment of caspase inhibi-tors....
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Tài liệu Báo cáo khoa học: Inorganic phosphate regulates the binding of cofilin to actin filaments pdf
... of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, USAActin dynamics, the polymerization and depolymeriza-tion of actin filaments and formation of ordered ... ofbreakage and destruction of filaments upon exposure toSDS and potassium iodide (KI) [30], and the decreasedtryptic susceptibility of the 60–69 loop in subdomain 2[31].Phosphate and its BeFx ... to F-actin. On the otherhand, cofilin accelerates Pi dissociation from F-actin[34] and prevents conformational changes that accom-pany Pi binding. Thus, Pi, cofilin, and pH can intri-cately...
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Tài liệu Báo cáo khoa học: Adaptive changes in the expression of nuclear and mitochondrial encoded subunits of cytochrome c oxidase and the catalytic activity during hypoxia pptx
... genes CytOX5a and CytOX5b, coding for thetwo isofoms Va and Vb, parallels that of genes CYC1 and CYC7, which encode iso-1 and iso-2 of yeast cytochrome c,respectively. CytOX 5a and CYC1 are ... resolved as two majorcomplexes, which comigrated with Apo-ferritin and b-amylase. Based on the rates of migration, the slowmigrating complex may be a dimmer and the fastermigrating complex migrating ... 0.1% Chaps and 150 mMNaCl and protease inhibitors [5 lgÆmL)1pepstatinA, 5 lgÆmL)1aprotinin, and 1 mMphenylmethanesulfonylfluoride]) and lysed by three cycles of freezing and thawingin...
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Báo cáo khoa học: Heterologous synthesis of cytochrome c¢ by Escherichia coli is not dependent on the System I cytochrome c biogenesis machinery ppt
... Allochromatium vinosum cytochrome c¢; Ccm, cytochrome c maturation; Dsb, disulfide bond formation; EC b562, Escherichia coli cytochrome b562; PHCP, Hydrogenophilus thermoluteolus cytochrome c¢;PHc552, ... cyto-chrome c¢ (PHCP) and H. thermoluteolus cytochrome c552(PH c552)genes are indicated as c¢ and c552, respectively. The arrow and arrowhead indicate the positions of the PHCP and PH c552proteins,respectively. ... JapanIntroductionCytochromes c¢ are classified as class II cytochromes caccording to Ambler [1], and are found in the peri-plasm of certain Gram-negative Alpha-, Beta- and Gammaproteobacteria....
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Báo cáo khoa học: NF-jB regulates the transcription of protein tyrosine kinase Tec pdf
... inactivation of Btk and Tec genes in micecause a severe phenotype resembling XLA. Tec is involved in the regula-tion of both B and T lymphocytes, fine-tuning of TCR ⁄ BCR signaling, and also activation ... T-cell line Jurkat and in two liver cell lines,HepG2 and Huh7 (Fig. 5C, left part, and data notshown). The proteasome and NF-jB inhibitors represstranscription from the Tec-920 and Tec-1800 promo-ters ... antigen presentation and apoptosis[49,50]. The ubiquitin proteasome pathway controlskey cellular and biological processes and thereforeplays crucial roles in health and disease, and there isincreasing...
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