Báo cáo khoa học: Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast pptx

... FEBS 2003 Critical role of the plasma membrane for expression of mammalian mitochondrial side chain cleavage activity in yeast Catherine Duport 1, *, Barbara Schoepp 1,† , Elise Chatelain 1 , Roberto ... The levels of expression of various proteins (Adxp, Adrp, CYP11A1) involved in the reaction can also affect the efficiency of cholesterol sid...

Ngày tải lên: 08/03/2014, 08:20

... accumulation of the toxin by the food chain in the organisms living close to the zoan- thid colonies [3]. It has been reported that dinoflagellates of the genus Ostreopsis are the most probable origin of ... impor- tance of the unpolymerized actin pool for the mainte- nance of the F-actin system, the cellular response Fig. 3. Response induced by palytoxin an...

Ngày tải lên: 18/02/2014, 14:20

... into the GCPII-binding pocket and proposed/ analyzed the amino acid residues involved in the ligand– protein interactions. All of the residues identified are situated within the segment spanning ... Arg538, i.e. the putative catalytic domain (domain E) and the D domain of rat GCPII. The contribution of domains C and F to the GCPII hydrolytic activity/ inhibitor bindi...

Ngày tải lên: 07/03/2014, 15:20

... reloca- tion upon inhibitor binding and, in addition, a rota- tion of the Asn257 side chain is necessary to accommodate the bulky oxodiazolidine ring. These observations are in line with the four-fold ... partially (Fig. 4). One of the reasons for the apparent prefer- ence of the lid to adopt the ‘open’ conformation in GCPIII might be a result of the Gly548...

Ngày tải lên: 23/03/2014, 05:22

... and any other domains, domainj seems to be the domain of unit~. The system se- lects the domain which is the largest of all sim- ilarities in N of domains as the domain of the unit (formula ... news into segments according to the length of pauses. We call the segments units. The domain which has the largest similarity between the unit of news and th...

Ngày tải lên: 20/02/2014, 18:20

... processed dsDNA, which suggests activation of the cellular machinery involved in silencing of RNA. For the silencing of viral RNA effected with dsDNA, we coined the term DNA interference technology. Abbreviations Ago, ... multidomain members of the RNase III fam- ily that are responsible for processing long dsRNAs into effector siRNAs. Human Dicer contains a single PAZ d...

Ngày tải lên: 16/03/2014, 02:20

... for training and the other pair for testing. We evaluate the precision over the 10 3 highest-probability predictions on the test set. In Figure 5, we vary the size of the corpus in the train pair ... directly as training examples for our classifier. To generate training examples, we need to map the entities back to mentions in the corpus. We denote the relatio...

Ngày tải lên: 30/03/2014, 17:20

... obese mice In order to gain insights into the potential biologically relevant role of miR-27 in the regulation of adipose tis- sue functions in vivo, we examined the expression of miR-27 in the genetically ... together, these results illustrate a critical and specific role of miR-27 in the regulation of adipogenic differentiation. miR-27 prevents the ind...

Ngày tải lên: 18/02/2014, 08:20

... potential of the haem, rate constants o f CO, O 2 and CN b inding to haem, and CD spectra in the Soret region [15–18], suggesting that this residue is critical for maintaining the electronic states of ... binding access channel a t t he haem distal side and/or structure in t erms of cyanide binding in the Fe(III) complex. Redox potentials The redox state of haem...

Ngày tải lên: 19/02/2014, 16:20

... BS-RNase. As the dimerization event occurs outside the cells, before internalization, we investigated the role of plasma mem- branes (PM) in the transformation of MSSAE into a dimeric protein. 125 I-labelled ... plateau. These data indicate that the cell sulfhydryls responsible for the exchange with the protein disulfides are located in the plasma membrane. Fur...

Ngày tải lên: 20/02/2014, 11:20